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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 5816960, 16 pages
https://doi.org/10.1155/2017/5816960
Research Article

Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

1Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China
2Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China
3Zhejiang Academy of Medical Sciences, Hangzhou 310053, China
4Wenzhou Medical University, Wenzhou, Zhejiang 325035, China

Correspondence should be addressed to Su-Hong Chen; nc.ude.tujz@gnohusnehc and Gui-Yuan Lv; moc.361@yglmctjz

Received 30 October 2016; Accepted 20 December 2016; Published 24 January 2017

Academic Editor: Waris Qidwai

Copyright © 2017 Bo Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.