Research Article

Oral Administration of Tualang and Manuka Honeys Modulates Breast Cancer Progression in Sprague-Dawley Rats Model

Table 9

The immunohistochemical expression of proapoptotic proteins in TH and MH treated tumours compared with the tumours of nontreated control; (a) +ive control for immunohistochemistry (IHC) analysis, (b) +ive control for study (group bearing breast cancer but received no honey treatment), (c) 1.0 g/kg TH, and (d) 1.0 g/kg MH. All specimens were examined at ×400 microscopic magnification and brown color showed antibody positivity. FASLG and FADD showed no expression in tumours of all treatment groups, while tumours in treated groups showed a higher expression of proapoptotic proteins than those of nontreated control. FASLG: fas ligand, FADD: fas-associated via death domain, IFNGR1: interferon gamma receptor 1, TH: Tualang honey, and MH: Manuka honey.

Proteins+ive control
(for IHC)
Group 1
+ive control
Group 2
1.0 g/kg TH
Group 3
1.0 g/kg MH

Caspase-9,
IHC
+ive control is human
colon
Apaf-1,
IHC
+ive control is human
colon
P53,
IHC
+ive control is human breast cancer
FASLG,
IHC
+ive control is human colon cancer
FADD,
IHC
+ive control is human breast cancer
IFNGR1,
IHC
+ive control is human
colon