Antidepressant-Like Effect of Selected Egyptian Cultivars of Flaxseed Oil on a Rodent Model of Postpartum Depression

Figure 4

Time spent in open and closed arms on the elevated plus maze test. Each value represents the mean of 8 rats ± SE. The different superscripts (a–d for open arm and A–D for closed arm) indicate a significant difference between groups using one-way ANOVA using SPSS software (version 22) followed by Duncan’s multiple-comparison test at . PPD: postpartum depression; G9 and G10: flaxseed oil from cultivars Giza 9 and Giza 10; and FLX: fluoxetine. PPD exhibited significant decrease in the time spent in open arm and increase in the time spent in closed arm versus sham-operated group. However, treatment with either flaxseed oil cultivars (G9 and G10) or fluoxetine significantly increased the time spent in open arm in order of FLX ≥ G9 > G10 and decreased the time spent in closed arm in order of FLX > G9 ≥ G10 versus PPD group.