Research Article

A Molecular Basis for the Inhibition of Transient Receptor Potential Vanilloid Type 1 by Gomisin A

Table 1

Effects of gomisin A on mutant TRPV1 receptor channel.

maxIC50

Wild type
A452Y
Y453A
Y454A
R455A
V456A
L465A
K466A
N467A
T468A
V469A
YNA2

Values represent the means ± SEM (/group). Currents were elicited at a holding potential of −80 mV. IC50 (μM), , and Hill coefficient values were determined as described in Materials and Methods.