Ping-Chong-Jiang-Ni Formula Induces Apoptosis and Inhibits Proliferation of Human Ectopic Endometrial Stromal Cells in Endometriosis via the Activation of JNK Signaling Pathway

Figure 5

PCJNF induced cell apoptosis and this effect was dependent on the activation of JNK signaling pathway in EESCs. (a) Compared with different control group (CONT, DMSO, and NS), the percentage of apoptotic cells treated with PCJNF-containing serum increased significantly (), and JNK inhibitor SP600125 could significantly abrogate this effect (). There was no significant difference of cell apoptosis between the “NS” and “NS + SP600125” group (). (b) Analysis of apoptosis rates using bar graphs. Cell apoptosis was assessed by flow cytometry. Data are presented as means ± SD of three independent tests.

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