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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 6756793, 8 pages
https://doi.org/10.1155/2017/6756793
Research Article

Preparation of a Nanoemulsion with Carapa guianensis Aublet (Meliaceae) Oil by a Low-Energy/Solvent-Free Method and Evaluation of Its Preliminary Residual Larvicidal Activity

1Post-Graduate Program in Tropical Biodiversity, Federal University of Amapá, Rodovia Juscelino Kubitschek, KM-02, Macapá, AP, Brazil
2Laboratory of Phytopharmaceutical Nanobiotechnology, Federal University of Amapá, Rodovia Juscelino Kubitschek KM-02, Macapá, AP, Brazil
3Laboratory of Drug Research, Federal University of Amapá, Rodovia Juscelino Kubitschek, KM-02, Macapá, AP, Brazil
4Laboratory of Arthropoda, Federal University of Amapá, Rodovia Juscelino Kubitschek, KM-02, Macapá, AP, Brazil
5Faculdade de Farmácia e Bioquímica, Campus Governador Valadares, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil
6Brazilian Agricultural Research Corporation (EMBRAPA), Rodovia Juscelino Kubitschek, No. 2600, Macapá, AP, Brazil
7Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), C/Jordi Girona, No. 18-26, Barcelona, Spain

Correspondence should be addressed to Caio P. Fernandes

Received 7 December 2016; Revised 6 March 2017; Accepted 16 May 2017; Published 17 July 2017

Academic Editor: Victor Kuete

Copyright © 2017 Flávia L. M. Jesus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Andiroba (Carapa guianensis) seeds are the source of an oil with a wide range of biological activities and ethnopharmacological uses. However, few studies have devoted attention to innovative formulations, including nanoemulsions. The present study aimed to obtain a colloidal system with the andiroba oil using a low-energy and organic-solvent-free method. Moreover, the preliminary residual larvicidal activity of the nanoemulsion against Aedes aegypti was evaluated. Oleic and palmitic acids were the major fatty acids, in addition to the phytosterol β-sitosterol and limonoids (tetranortriterpenoids). The required hydrophile-lipophile was around 11.0 and the optimal nanoemulsion was obtained using polysorbate 85. The particle size distribution suggested the presence of small droplets (mean diameter around 150 nm) and low polydispersity index (around 0.150). The effect of temperature on particle size distribution revealed that no major droplet size increase occurred. The preliminary residual larvicidal assay suggested that the mortality increased as a function of time. The present study allowed achievement of a potential bioactive oil in water nanoemulsion that may be a promising controlled release system. Moreover, the ecofriendly approach involved in the preparation associated with the great bioactive potential of C. guianensis makes this nanoemulsion very promising for valorization of this Amazon raw material.