A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of<i> Mangifera indica</i> (Mango)

Ediriweera, Meran Keshawa; Tennekoon, Kamani Hemamala; Samarakoon, Sameera Ranganath

doi:https://doi.org/10.1155/2017/6949835

Evidence-Based Complementary and Alternative Medicine

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Review Article | Open Access

Volume 2017 | Article ID 6949835 | https://doi.org/10.1155/2017/6949835

A Review on Ethnopharmacological Applications, Pharmacological Activities, and Bioactive Compounds of Mangifera indica (Mango)

Meran Keshawa Ediriweera,¹Kamani Hemamala Tennekoon,¹and Sameera Ranganath Samarakoon¹

Academic Editor: Gabino Garrido

Received04 Sept 2017

Revised29 Oct 2017

Accepted19 Nov 2017

Published31 Dec 2017

Abstract

Mangifera indica (family Anacardiaceae), commonly known as mango, is a pharmacologically, ethnomedically, and phytochemically diverse plant. Various parts of M. indica tree have been used in traditional medicine for the treatment of different ailments, and a number of bioactive phytochemical constituents of M. indica have been reported, namely, polyphenols, terpenes, sterols, carotenoids, vitamins, and amino acids, and so forth. Several studies have proven the pharmacological potential of different parts of mango trees such as leaves, bark, fruit peel and flesh, roots, and flowers as anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial, and antihyperlipemic. In the present review, a comprehensive study on ethnopharmacological applications, pharmacological activities, and bioactive compounds of M. indica has been described.

1. Introduction

M. indica L. is considered as one of the main tropical fruits in the world believed to be originated from Asia [1]. It has been reported that China, India, Brazil, Nigeria, Pakistan, Mexico, Thailand, and Philippine are well-known for mango cultivation with India being the highest mango cultivating country [2]. World production of mango is approximately 42 million tons per year which is second only to banana production. There are about 1000 mango varieties grown all over the world [2–4]. Mango is known by various names around the world, for example, Manja in Arabic, Mannko in Greek, Am or Ambi in Hindi, Amba in Sinhala, Mangue in French, Mango in Finnish, Mango in Dutch, Mangue in German, Mángguǒin in Chinese, and Mampalam in Tamil [5]. Both ripe or unripe mango fruits are in human use as pickles, juice, oils, nectar, powder, sauce, cereal flakes, and jam [6]. Mango fruit peel and flesh are reported to be a rich source of fiber, vitamin C and A, essential amino acids, and polyphenols [7]. Mango seed has also been reported as a rich source of polyphenols [8]. Despites the common use of mango fruit as a food item, various parts of mango trees have also been used for medical purposes since ancient times, mostly in Southeast Asian and African countries [9]. Much evidence is found in literature on pharmacological and ethnomedicinal uses of M. indica; however, there is no complete review on phytochemicals, biological effects of phytochemicals, and pharmacological and ethnomedicinal properties of M. indica. Therefore, we present this review as an up-to-date and comprehensive evaluation which mainly includes phytochemicals, some reported bioactivities of phytochemicals, and pharmacological and ethnomedicinal properties of M. indica.

2. Taxonomy and Botanical Description of M. indica

The genus Mangifera belongs to the family Anacardiaceae. Genus Mangifera approximately contains 69 different species with M. indica being the most common species in the same genus [10, 11]. M. indica plant is an evergreen broad canopy tree which grows to a height of 8–40 m [12]. M. indica bark is a thick brown-gray colour and is superficially cracked [13]. Leaves are 15–45 cm in length with variable sizes [13]. Leaf petiole has a variable length from 1–10 cm [13]. M. indica leaves (Figure 1) possess different shapes (lanceolate, ovate-lanceolate, linear-oblong, roundish-oblong, oval, and oblong) [13]. Green, red, and yellow leaves are seen in some mango varieties and upper leaf surfaces are normally shiny [13, 14]. In case of M. indica flowers, male and hermaphrodite flowers are produced in the same panicle; its size can vary from 6–8 mm in diameter. There are about 4000–5000 small flowers in panicles with red/purple spots on petals [13, 14]. Even though a large number of flowers present in panicles, very few will be developed as fruits. Flowering season is mainly from January to April and most of the flowers are subsessile and have a sweet smell. M. indica fruit (Figure 1) is drupe with different sizes, shapes, and colours. Fruit peel is green, yellow, red, or orange. Seeds are ovoid- or oblong-shaped covered with a hard endocarp having a woody fiber covering [15].

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3. Ethnomedicinal Use

Various parts of M. indica (bark, leaves, roots, fruits, and flowers) have been used in traditional medicine for the treatment of various diseases and conditions. Ethnomedicinal uses of various parts of M. indica in different countries in the world have been summarized in Table 1.

4. Chemistry

4.1. Phytochemicals in M. indica

A large variety of chemical compounds have been reported in M. indica [30]. Among these, polyphenols (flavonoids, xanthones, and phenolic acids) are the most abundant compound types in M. indica [31]. Mangiferin, gallic acid, catechins, quercetin, kaempferol, protocatechuic acid, ellagic acids, propyl and methyl gallate, rhamnetin, and anthocyanins are the major polyphenolic compounds found in M. indica [32]. Mangiferin is a well-known polyphenolic compound which has been extensively studied for its numerous biological properties [33]. The quantities of different polyphenols in mango depend on the part and variety of mango [34]. Antioxidant properties have been shown to be the main biological property of almost all the M. indica polyphenols [35]. Ascorbic acid and dehydroascorbic acid (oxidized form of ascorbic acid) are two other common polyphenols found in M. indica [36]. The amount of polyphenols is high in many parts of M. indica. Thus, a pure compound alone has been proven to be less effective than crude drugs, implying that the synergism of many M. indica polyphenols is essential for optimum biological activities [37, 38]. Carotenoids are another class of natural compounds found in plants. They are considered as natural organic pigments [39]. The bright yellow colour of M. indica fruit peel and flesh is due to the presence of carotenoids [39]. Biologically they are very good free radical scavengers [40]. It has been reported that carotenoids in M. indica are biosynthesized in the fruit and carotenoid concentration rises upon ripening [41]. β-carotene, luteoxanthin, violaxanthin, neoxanthin, zeaxanthin, and cryptoxanthin are the main carotenoids found in M. indica fruit flesh and peel [42]. Among these, β-carotene is the most abundant [42]. Terpenoids are a class of lipids, similar to terpenes, commonly found in the plant kingdom [43]. M. indica is reported to contain several terpenoids, including careen, ocimene, terpinolene, myrcene, or limonene [44]. These terpenoids are volatile and responsible for aroma in M. indica [45]. Lupeol and lupeollinoleate are two other common triterpenoids found in mango [46]. Gallotannins (hydrolyzable tannins) are another class of chemical compounds found in M. indica bark, leaves, kernel, and fruit pulp [47]. The presence of tocopherols in M. indica has also been reported. Alpha-tocopherol, beta-tocopherol, and gamma-tocopherol are commonly found tocopherols in M. indica fruit peel and flesh [48]. Resorcinolic lipids (phenolic lipids) are another class of natural compounds found in M. indica [49]. The isolation of a wide range of resorcinolic lipids with different biological properties has been reported from M. indica fruit peels, flesh, and bark [49]. The isolation of a novel resorcinolic lipid from the bark of Mangifera zeylanica (endemic Sri Lankan mango) with anticancer effects has been presented in a study carried out by us [50]. It was thought that halogenated compounds are limited only to marine plants and microorganisms. However, occurrence of halogenated compounds in the bark of M. indica has been reported in a study conducted in India [51]. A recent study carried out by us also reported the isolation of two novel halogenated compounds (chloromangiferamide and bromomangiferic acid) from the bark of M. zeylanica [52]. Structures of some common compounds present in M. indica are shown in Figures 2(a) and 2(b). Quercetin and mangiferin are most commonly found in M. indica. As these two compounds containing food items (including mango fruits) are very common in human diet, studies on their safety and toxicity have been well-documented [17, 53–55]. Moreover, kaempferol, another well-known mango compound, has also been subjected to various safety and toxicity studies in order to validate its uses in human diet [56–58]. In most of the studies it has been mentioned that quercetin mangiferin and kaempferol are less toxic in studied animal models.

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4.2. Reported Phytochemicals in Different Parts of M. indica

4.2.1. Leaves

Amino acids include alanine, glycine, valine, tyrosine, leucine, and γ-aminobutyric acid. Polyphenols and phenolic acids include protocatechuic acid, gallic acid, hyperin, catechin, quercetin, mangiferin, kainic acid, ethyl digallate, ellagic acid, and shikimic acid. Alcohols include methylic, ethyl, and isobutyl alcohols. Terpenes include α-pinene, β-pinene, δ-elemene, taraxerol, β-elemene, α–cubebene, camphene, γ–cadinene, lupeol, friedelin, linalool, β-bulnesene, α-guaiene, humulene, α-farnesene, myrcene, car-3-ene, limonene, β-ocimene, γ–terpinene, and α-terpinolene. Phenylpropenes include estragole, methyleugenol and elemicin. Sterols include α, β, and γ-sitosterol [59–64].

4.2.2. Fruit Peel and Flesh

Triterpenes and triterpenoids include cycloartenol, α-amyrin, β-amyrin, ocotillol, 3b-hydroxycycloart-24-en-26-al, 24-methylene-cycloartan-3b,26-diol, dammarenediol II, and psi-taraxastane-3b. Polyphenols and phenolic acids include ascorbic acid, quercetin, mangiferin, quercetin 3-ara, quercetin 3-rha, isomangiferin gallate, mangiferin gallate, methyl mangiferonate, methyl mangiferolate, tetra-O-galloylglucose, hexa-O-galloylglucose, methyl isomangiferolate, caffeic acid, ferulic acid, gallic acid, cinnamic acid, vanillin, rhamnetin-3-O-galactoside, kaempferol, and kaempferol-hexose. Resorcinolic lipids include 5-(11′Z-heptadecenyl)-resorcinol and 5-(8′Z,11′Z-heptadecadienyl)-resorcinol. Carotenoids include β-carotene, cis-violaxanthin, neochrome, cis-neoxanthin, luteoxanthin, zeaxanthin, and 9- or 9′-cis-lutein. Long-chain fatty acids include oleic acid, linoleic acid, linolenic acid, and n-pentacosanol [49, 59–64].

4.2.3. Root

Triterpenes and triterpenoids include friedelin, friedelan-3b-ol, -amyrin, -amyrin, and cycloartenol. Sterols include -sitostero and 3-methoxy-2-(4′-methyl benzoyl)-chromone [59–64].

4.2.4. Bark

Polyphenols and phenolic acids include protocatechuic acid, catechin, mangiferin, benzoic acid, kainic acid, gallic acid, shikimic acid, and kaempferol. Triterpenes and triterpenoids include cycloart-24-en-3b,26-diol, 3-ketodammar-24(E)-en-20S,26-diol, friedelin, mangocoumarin, manglupenone, manghopanal, cycloartan-3β-30-diol cycloartan-3b,24,27-triol, mangoleanone, mangiferolic acid ethyl ester, mangiferolate A and mangiferolate B, and 29-hydroxymangiferonic acid. Halogenated amide includes 3-chloro-N-(2-phenylethyl) propenamide. Long-chain hydrocarbons include N-triacontane, N-tetracosane, and 9,12-tetradecadiene-1-ol-acetate. Terpenoid saponins include indicoside A and B. Amino acids include alanine, glycine, and γ-aminobutyric acid [51, 59–65].

4.2.5. Seed and Kernel

Long-chain hydrocarbons and fatty acids include stearic acid, eicosanoic acid, linoleic, linolenic, oleic acid, arachidonic acid, and palmitic acid. Sterols include stigmasterol, sitosterol, and campesterol. Triterpenes and triterpenoids include α-pinene, β-pinene, myrcene, and limonene. Polyphenols and phenolic acids include ascorbic acid, mangiferin, quercetin, and gallic acid [59–67].

4.2.6. Flowers

Amino acids include threonine, valine, alanine, and tryptophan. Polyphenols and phenolic acids include gallic acid, mangiferin, quercetin, and ellagic acid. Triterpenes and triterpenoids include β-pinene, nerol, limonene, α-phellandrene, and α-pinene [59–68].

5. Pharmacological Properties of M. indica

A number of in vitro and in vivo studies have been carried out to reveal various pharmacological potentials of M. indica. Different parts of M. indica trees have been demonstrated to exert anticancer, anti-inflammatory, antidiabetic, antioxidant, antibacterial, antifungal, anthelmintic, gastroprotective, hepatoprotective, immunomodulatory, antiplasmodial and antihyperlipemic effects [69]. Many of these pharmacological studies on different parts (as organic extracts or decoctions) of M. indica trees have been carried out to validate the ethnomedical uses of the plant in traditional medicine in the treatment of several diseases and conditions. A large number of pharmacological studies on M. indica have been conducted mainly in India and Bangladesh. A considerable number of pharmacological studies have also been reported from countries like Brazil, Nigeria, and Iran. Some experimentally proven pharmacological properties of different parts of M. indica trees have been described in detail in the following section.

5.1. Antioxidant Properties of M. indica

Antioxidants are substances which inhibit/delay oxidative damage by trapping free radicals to a target molecule [70]. Several classes of natural compounds including polyphenols, phenolic acids, and flavonoids are reported as good free radical scavengers [71]. It has been reported that reactive oxygen species (ROS) and some other oxidants cause various disorders and diseases to human [71]. Humans possess antioxidative mechanisms which fight against reactive oxygen species (ROS) and some other oxidants by deactivating free radicals before they attack targets in human body [72]. Naturally occurring antioxidants have gained much attention recently as they possess a remarkable ability to fight against free radicals and reactive oxygen species [72]. As almost all the parts of the mango tree are reported to possess polyphenols, which are well-known antioxidants, most of the pharmacological studies have proven that antioxidant properties with extract(s) of various parts of the M. indica tree are related to polyphenolic content. The following section will summarize some selected studies which illustrate antioxidant effects of different parts of M. indica. A recent study carried out by Thambi et al. 2016 [73] evaluated antioxidant effects of mango peel powder and proved that the acetone extract of the M. indica peel exerts strong radical scavenging effects. A research carried out by Abbasi et al. 2017 [74] with nine mango varieties (Royal mango, Thai mango, Egg mango, Luzon, Narcissus, Big Tainong, Keitt, Australian mango, and Small Tainong) found in China found that the peel of Small Tainong (Xiao Tainong) variety exerts the highest antioxidant potential among the tested varieties. Another study conducted by Sultana et al. 2012 [75] measured the antioxidant potential of water-methanol extracts of the peels of two mango varieties (Langra and Chaunsa) grown in Pakistan. Among these two peel extracts, water-methanol extract of Chaunsa exhibited strong antioxidant effects than Langra. Kim et al. 2010 [76] who studied antioxidant effects of ethanolic extracts of mango peel and flesh showed potent antioxidant effects of mango peel extracts compared to flesh extracts. Effect of temperature on the antioxidant activity of mango peel extracts (a variety found in Spain) was studied by Dorta et al. 2012 [77]. Methanol, ethanol, acetone, water, methanol-water, acetone-water, and ethanol-water extracts were subjected to radical scavenging activity and methanol-water, acetone-water and ethanol-water extracts were found to possess high antioxidant capacity when the temperature is increased from 50−70°C. A number of studies around the world have evaluated the antioxidant effects of mango fruit flesh. A study conducted with methanol extracts of fruit flesh of two mango varieties (Americana and Jose) grown in France by Septembre-Malaterre et al. 2016 [78] has shown that methanol extracts of both these varieties exert antioxidant effects. A comparative study has been carried out with fruit flesh of five mango varieties (Langara, Fazli, Amrupali, Himsagor, and Ashwina) grown in Bangaladesh [79]. Methanolic extracts of all the tested mango varieties exerted considerable antioxidant effects and the fruit flesh extract of Langra exerted the highest effect. Another comparative study carried out with methanol/dichloromethane and aqueous extracts of fruit flesh of four Egyptian mango varieties (Zebdia, Sukkari, Taimor, and Hindi) showed that methanol/dichloromethane extracts of all the varieties have prominent antioxidant effects than the aqueous extracts [80]. Antioxidant potential of ethanolic extract of the seed of an M. indica variety grown in Malaysia has been reported by Norshazila et al. 2010 [81]. Pitchaon, 2011 [82], has demonstrated antioxidant capacity of seed kernel obtained from a mango variety (Chok-Anan) grown in Thailand. Two kernel extracts have been prepared by acid hydrolysis and shaking in ethanol. The results of this study showed that the extract prepared by acid hydrolysis has a high antioxidant potential than the extract prepared by shaking in ethanol. Sultana et al. 2012 [75] have presented antioxidant potential of water-methanol extracts of the bark of two M. indica varieties (Langra and Chaunsa) grown in Pakistan. The bark of the variety Chaunsa exerted a higher antioxidant potential than Langra. Antioxidant effects of methanolic extract of M. indica leaves have been reported by Mohan et al. 2013 [83]. They showed that ethyl acetate and butanol fractions obtained after solvent partition of the crude methanol extract have antioxidant effects.

5.2. Anti-Inflammatory Effects of M. indica

Several naturally found polyphenols are reported to possess anti-inflammatory effects via inhibition of nuclear factor kappa-B (NF-κB) [84]. However, anti-inflammatory activities of these compounds depend on their chemical structures and their cellular targets [84]. Production of a large amount of proinflammatory cytokines (IL-1, 2 and 6 and TNF) increase the expression of enzymes such as COX-2 and iNOS which are associated with anti-inflammations [85]. Nuclear factor kappa-B (NF-κB), a transcriptional factor, is reported to control expression of proinflammatory cytokines [86]. Ulcerative colitis and inflammatory bowel disease are considered as main diseases that occur due to chronic inflammation [87]. Several studies have shown that mango extracts can exert anti-inflammatory effects in experimental models of ulcerative colitis. In a recent study, treatment with a mango beverage prepared from fruit (Mexican variety) which consists of polyphenols and vitamins has caused attenuation of colitis symptoms by expressing the PI3K/AKT/mTOR pathway [88]. Another study conducted by the same authors showed that the same mango polyphenols-rich beverage can inhibit the IGF-1R/AKT/mTOR pathway in ulcerative colitis [89]. In another study, aqueous extract of stem-bark extract from M. indica rich in polyphenols and flavonoids was found to attenuate colitis symptoms in a model of colitis [90]. Attenuation of symptoms was accompanied by a reduction in COX-2, TNFR-2, TNF-α, and iNOS levels in colonic tissue. Gout is considered as one of the most common causes of inflammatory arthritis. Deposition of monosodium urate crystals on local tissue and joints is the major clinical manifestation of gout [91]. Antigouty arthritis effects of ethanol extract of M. indica leaves have been studied by Jiang et al. 2012 [91]. Oral administration of ethanol extract of M. indica leaves has caused reduction in IL-1β and TNF-α mRNA levels and ankle swelling in a rat with gouty arthritis induced by monosodium urate [91].

Vimang is an aqueous extract of M. indica (stem-bark) used in Cuba as a natural supplement [92]. A number of in vivo and in vitro studies have been conducted with Vimang to demonstrate its antioxidant effects. A study carried out by Garrido et al., 2004 [92], has shown that administration of Vimang can reduce arachidonic acid (AA) and phorbolmyristate acetate-induced ear edema in mice. Reduction in myeloperoxidase (MPO) activity was observed in phorbolmyristate acetate-induced mice. Inhibition of tumor necrosis factor alpha (TNF) serum levels was also observed in both models of inflammation after administration of Vimang. In vitro evaluations carried out with Vimang have shown that it can inhibit PGE2 (prostaglandin E2) or LTB4 (Leukotriene B4) in macrophage cells (RAW264.7) induced with proinflammatory stimuli. Another study conducted by Garrido et al., 2001 [93], has also shown possible anti-inflammatory effects of Vimang. Carrageenan and formalin-induced oedema in mice were used to study anti-inflammatory effects in this study. Results of this study have shown that Vimang can significantly inhibit carrageenan- and formalin-induced oedema (in rat, guinea pigs, and mice). Moreover, Garrido et al., 2004 [94], have shown for the first time that Vimang can block TNFα (tumor necrosis factor alpha) and inhibit the production of NO (nitric oxide) in macrophages (RAW264.7 and N9) and in mice model of septic shock. Martnez et al., 2000 [95], have evaluated in vitro antioxidant effects of Vimang with the help of some commonly accepted assays. Strong radical scavenging activity and a significant inhibition of peroxidation of rat-brain phospholipids by Vimang were observed in this study.

Neuroprotective efficacy of mangiferin in doxorubicin (DOX)-induced rats has been studied by Siswanto et al., 2016 [96]. Brain damage in male Sprague-Dawley rats has been induced by doxorubicin, and mangiferin has been given to brain damage-induced rats for 7 weeks. Results of this study have shown that mangiferin can effectively reverse the brain damage induced by doxorubicin. Cognitive enhancing effects and improvement in memory impairment by M. indica fruit pulp extract (ethanol) were studied by Wattanathorn et al., 2014 [97]. To determine cognitive enhancing effects and improvement in memory impairment, male Wistar rats have been administered with the neurotoxin AF64A and given the fruit peel extract. Results of the study have shown increased cholinergic neurons density and decreased oxidative stress in rates, which illustrates possible cognitive enhancing effects of M. indica fruit pulp. Neuroprotective activities of methanol and aqueous extracts of M. indica leaf have been studied by Kawpoomhae et al., 2010 [98]. Neuroprotective effects of methanol and aqueous extracts were evaluated by determining protection of neuroblastoma cells from H₂O₂-induced oxidative damage and results showed that methanol extract and aqueous extract can effectively protect H₂O₂-induced neuroblastoma cells from oxidative damage.

Liver, a vital organ in the human body, mainly regulates metabolism and detoxification of toxic substances [166]. It plays an important role by removing reactive oxygen species (ROS) and helps maintains oxidative balance [167]. A number of chemical substances that cause hepatotoxicity by inducing oxidative damage and lipid peroxidation have been identified [168]. Hepatotoxicity is currently treated with drugs that can activate p450 enzyme mechanism either by stopping or inducing the metabolic activity of enzymes [169]. Investigation of phytochemicals with hepatoprotective effects and their mechanism of action has gained much attention. Many authors have investigated hepatoprotective effects of certain plant extracts/pure compounds including M. indica. Ebeid et al. 2015 [170] have demonstrated hepatoprotective effects of an aqueous extract of leaves of an M. indica variety found in Egypt where they found that the aqueous extract successfully inhibited CCl₄-induced hepatocellular toxicity in albino rats. Results were further confirmed by analyzing lipid profiles, high-density lipoprotein (HDL), and malondialdehyde (MDA) levels. An in vitro study carried out by Hiraganahalli et al. 2012 [171] has shown that methanol/acetone extract of M. indica bark can exert hepatoprotective effects in tert-butyl hydroperoxide-induced HepG2 cells in a dose-dependent manner. Hepatoprotective effects of lupeol and aqueous M. indica pulp extract (collected from Lucknow, India) have been studied in 7,12-Dimethylbenz[a]anthracene (DMBA)-induced Swiss albino mice. Lupeol and mango M. indica extract were found to be effective in the treatment of liver injury caused by oxidative stress [172]. Pourahmad et al. 2010 [173] investigated hepatoprotective effects of an aqueous extract of a mango fruit variety collected from Iran and demonstrated that the extract exerts hepatoprotective effects in cumene hydroperoxide-induced rat hepatocytes. Hepatoprotective effects of an ethanolic extract of kernel of a Thai M. indica variety have been also reported by Nithitanakool et al. 2009 [174]. Significant hepatoprotective effects of the ethanolic extract of kernel have been reported in rats with liver injuries induced by carbon tetrachloride (CCl₄).

5.3. Analgesic Effects

Analgesic effects of stem-bark aqueous extract of M. indica have been studied by Ojewole, 2005 [175]. Hot-plate and acetic acid test models of pain in mice have been used to study analgesic effects, and results of this study have demonstrated significant analgesic effects in mice with nociceptive pain. Islam et al. 2010 [176], have demonstrated analgesic effects of methanol extract of leaves of M. indica. Results have demonstrated a significant reduction in writhing response in an acetic acid-induced writhing response rat model. Garrido et al., 2001 [93], have shown possible analgesic effects of Vimang. Acetic acid-induced abdominal restriction and formalin-induced licking were used to test analgesia. Results of this study have shown that Vimang can exhibit antinociceptive effects in mice. Moreover, a considerable dose-dependent inhibition in formalin-induced pain was also observed in rats after administration of Vimang.

5.4. Immunomodulatory Effects of M. indica

Immunomodulation is a process that adjusts the immune system of an organism upon any change caused by a foreign agent [177]. Immunomodulation can be of two types, namely immunostimulation and immunosuppression [178]. Immunostimulation includes stimulation of the immune system with immunostimulating agents that activate components of the immune system (macrophages, certain T-lymphocytes and granulocytes) [178]. In immunosuppression, efficiency of the immune system decreases [178]. As clinically used immunomodulating drugs cause serious side effects, it is necessary to discover immunomodulating agents with fewer side effects [179]. Garrido et al. 2005 [180] have shown immunomodulatory activity of bark aqueous extract of a mango variety collected from Cuba. Inhibition of proliferation of T-cells and NF- κB transcription factor were reported in this in vitro study suggesting possible immunomodulation. Another study conducted in Cuba with an aqueous extract of mango bark has also shown in vivo immunomodulatory effects, where NOS-2, COX-2, IL-1β, TNF-α, and colony-stimulating factor (GM-CSF) mRNA levels were found to decrease in experimental mice model(s) [181]. Makare et al. 2001 [182] have assessed immunomodulatory effects of an ethanolic extract of mango bark rich in mangiferin in Swiss albino mice. Administration of the ethanolic bark extract increased delayed type hypersensitivity (DTH) and humoral antibody (HA) titer suggesting possible immunostimulation by the extract. Immunostimulatory effects of a mango kernel powder in a species of fish (Labeo rohita) infected with Aeromonas hydrophila have been studied by Sahu et al. 2007 [183], where increased immunological parameters (lysozyme activity, superoxide anion production, and bactericidal activity) were detected in fish fed with mango kernel powder. Moreover, a recent study has shown that a hexane leaf extract from M. indica collected from Varanasi, India, possesses immunomodulatory effects in RAW 264.7 cells. Immunomodulatory effects were confirmed by analyzing intracellular NO levels, where a significant increase in response to the leaf hexane extract was observed. Furthermore, oral administration of the leaf hexane extract has also caused increased white blood cells, hemoglobin concentration, and temporary increase in the size of spleen and thymus in cyclophosphamide-induced myelosuppressed mice, which indicates immunostimulation in bone marrow hematopoietic cells and white blood cells [184].

5.5. Antitumoral Effects of M. indica

Cancer is considered as one of the major causes of death in the world and any practical solution in fighting this dreadful disease would be very important in public health [185]. It is the main cause of death in economically developed countries and the second leading cause of death in economically developing countries [186]. Cancer is caused by several factors such as chemicals, radiations, tobacco, infectious microorganisms, hormones, gene mutations, and immune conditions [187]. Though, modern surgeries have considerably reduced the cancer death rates, use of radiotherapy, chemotherapy, and hormone therapy treatments cannot completely reduce the number of deaths due to cancer [188]. Plant-based treatments have been used in traditional medicine to treat different diseases including cancer since ancient times and a number of in vitro and in vivo studies have already been reported in literature to validate these uses [189]. Different organic extracts and decoctions prepared from parts of mango trees and compounds isolated from mango trees have shown anticancer effects.

A recent study by Abbasi et al. 2017 [74] demonstrated antiproliferative effects of fruit peel and pulp of several mango varieties (Royal mango, Thai mango, Egg mango, Luzon Narcissus, Big Tainong, Keitt, Australian mango, and Small Tainong) grown in China. They showed that the acetone extracts of mango peel and pulp exerted antiproliferative effects in HepG2 cells. Another study carried out by Kim et al. 2012 [190] has shown that the ethanolic extract of M. indica peel can induce apoptosis in human cervical adenocarcinoma HeLa cells. Apoptotic effects of the peel ethanolic extract have been studied by analyzing expression of apoptosis-related proteins Bax, Bcl-2, Bid, and caspases (3, 8, and 9) in this study. Phytochemical investigation of peel ethanolic extract has revealed that it contains some reported anticancer compounds such as quercetin 3-O-galactoside, gallic acid, linoleic acid, alpha-tocopherol, mangiferin gallate, mangiferin, kaempferol 3-glucoside and quercetin-3-O-arabinopyranoside. Protective effects of ethanolic extracts of mango fruit peel and flesh (a Korean variety) samples in H₂O₂-induced cytotoxicity in HepG2 cells have also been studied by this research group [76]. A study carried out by Corrales-Bernal et al. 2014 [191] has shown that aqueous extract of mango fruit flesh possesses antiproliferative effects in human colon adenocarcinoma cell line (SW480) and in mouse model with colorectal cancer. Antiproliferative effects of methanol extracts of peel and flesh of three mango cultivars (Kensington Pride (KP), Nam Doc Mai (NDM), and Irwin (IW)) found in Australia were studied by Taing et al. 2015 [192]. They have demonstrated that peel methanol extract of NDM can only inhibit the proliferation of MCF-7 breast cancer cells. Antitumor effects of mango polyphenols-rich fruit flesh extracts in human breast cancer xenografts mice have been studied by Banerjee et al. 2015 [193]. This study has proven that mango polyphenols rich fruit pulp extract has a potential to target PI3K/AKT pathway in breast cancer. Anticarcinogenic effects of a crude (methanol : acetone : water-1 : 1 : 1) fruit peel extract of some selected mango varieties (Kent, Francis, Atkins, Ataulfo, Tommy, and Haden, found in Brazil) have been evaluated in leukemia (Molt-4), lung (A-549), triple negative breast (MDA-MB-231), prostate (LnCap), and colon (SW-480) cancer cells by Noratto et al. 2010 [194]. Among the studied mango varieties, two (Ataulfo and Haden) were more sensitive to SW-480 and MOLT-4 cells. Moreover, apoptotic effects of Ataulfo and Haden varieties have also been studied in SW-480 cells in this study. Induction of apoptosis by aqueous extract of mango fruit peel rich in lupeol has been carried out in testosterone-induced mouse prostate and human prostate cancer cells (LNCaP) by Prasad et al. 2007 [195]. Antiproliferative effects of two extracts (pectinase and Soxhlet extracts) of mango flesh found in Australia have shown in oestrogen receptor positive (MCF-7) breast cancer cells by Wilkinson et al. 2011 [196].

Induction of oxidative stress mediated apoptosis by ethanolic extract of M. indica seed in triple negative breast cancer cells (MDA-MB-231) has been reported by Abdullah et al. 2015 [197]. In this study, apoptotic effects of ethanolic extract of M. indica seeds were evaluated by analyzing apoptosis-related marker proteins such as Bax, Bcl-2, cytochrome c, and caspases (3, 8, and 9). Involvement of oxidative stress markers such as reactive oxygen species (ROS), glutathione (GSH), and malondialdehyde (MDA) levels in apoptosis has also been studied. Another study [198] carried out by the same research group reported oxidative stress mediated apoptosis by ethanolic extract of mango seeds in oestrogen receptor positive breast (MCF-7) cancer cells. Nguyen et al. 2016 [199] have demonstrated cytotoxic effects of methanol bark extract of M. indica in pancreatic cancer cells (PANC-1). Isolation of two novel cycloartane-type triterpenes, namely, mangiferolate A and mangiferolate B, has also been reported in the same study. Studies on the anticancer effects of mango leaves are limited. Cytotoxic effects of ethanolic leaf extract of an M. indica variety grown in Thailand were investigated by Ganogpichayagrai et al. 2017 [200], but a very low cytotoxic potential by ethanolic extract has been reported in all the cancer cell lines tested. Hepatoblastoma (HepG2), gastric carcinoma (Kato-III), bronchogenic carcinoma (Chago K1), ductal carcinoma (BT474), and colon adenocarcinoma (SW 620) cell lines were used in this study. Cytotoxic and apoptotic potential of the bark of two mango varieties (Rata Amba and Kartha Kolomban Amba) grown in Sri Lanka in breast (MCF-7 and MDA-MB-231) and ovarian cancer (SKOV-3) cells has been recently reported by us [201]. In this study we found that methanolic extracts of bark of two mango varieties exert cytotoxic and apoptotic potential in breast and ovarian cancer cells. In addition to these findings, our recent findings have demonstrated that the hexane extract of bark and the chloroform extract of the fruit peel of Mangifera zeylanica, a plant endemic to Sri Lanka (Sri Lankan mango), can induce apoptosis in breast and ovarian cancer cells [202, 203]. Results of our studies showed that the hexane extract of bark of M. zeylanica has promising cytotoxic effects in breast (MCF-7 and MDA-MB-231) and ovarian cancer (SKOV-3) cells with less cytotoxicity to normal mammary epithelial (MCF-10A) cells [202]. Hexane extract also showed apoptotic effects in these cancer cells. Phytochemical investigation by GC-MS analysis of the active fractions of the hexane extract revealed few unknown compounds and we isolated a new resorcinolic lipid which was cytotoxic to MCF-7 breast cancer cells [50]. Furthermore, we isolated two new halogenated compounds namely chloromangiferamide and bromomangiferic acid from the chloroform extract of M. zeylanica bark [52]. Of these chloromangiferamide was cytotoxic only to MDA-MB-231 cells whereas bromomangiferic acid had no cytotoxic activity. Studies with the M. zeylanica fruit peel and flesh demonstrated that chloroform extract of fruit peel can induce apoptosis in MCF-7 breast cancer cells through an oxidative stress mechanism. Phytochemical identification of the peel chloroform extract of M. zeylanica showed presence of some reported anticancer compounds such as linoleic acid and α-tocopherol [203]. Mangiferin is a well-known bioactive xanthonoid found in various parts of the mango tree. A number of studies have been carried out to illustrate antitumoral effects of mangiferin in various cancer cell lines such as breast, lung, ovary, brain, and cervix, and possible antitumoral mechanisms of mangiferin in several cancer cell lines have also been well-documented [204].

5.6. Antibacterial Effects of M. indica

Resistance to antibiotics has become one of the biggest problems worldwide [205]. Unnecessary use of antibiotics for viral infections, prolong use of antibiotics for diseases, wrong prescriptions given to patients without determining the exact cause of infection, and discontinuation of antibiotics without completing treatments by patients are some of the major causes for occurrence of antibiotic resistance [206]. Approximately half of all deaths in tropical countries are due to bacterial infections [207]. Therefore, discovery of novel antibacterial agents for drug resistant bacteria is essential. A number of studies have proven the antibacterial effects of certain plant crude drugs and natural compounds isolated against drug resistant bacteria [208]. Herbal remedies for bacterial infections have gained much attention recently as they are readily available, cause fewer side effects, and cheap.

Various studies have been conducted with the extracts of roots, leaves, bark, fruit peel and flesh, and kernel of M. indica to investigate antibacterial properties. Among these parts, mango kernel and leaves are the most studied parts for antibacterial effects. A study carried out by Mutua et al. 2017 [209] with four M. indica varieties grown in Kenya (Apple, Ngowe, Sabine, and Kent) found that the methanol extracts of kernels of Apple and Sabine varieties exert strong inhibitory effects against Escherichia coli. Antibacterial effects of hexane, chloroform, benzene, methanol, and water extracts of kernel of an M. indica variety found in Tamil Nadu, India, have been reported by Rajan et al. 2011 [210]. The methanolic extract of the kernel was more potent in inhibiting the growth of Shigella dysenteriae, a causative agent for diarrhoea. Aqueous kernel extracts of two other M. indica varieties (Bagnapalli and Senthura) found in Tamil Nadu (Vellore) were subjected to study antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa by Alok et al. 2013 [211]. Aqueous extracts of Bagnapalli variety exerted a higher effect than the Senthura variety. Antibacterial effects of kernels obtained from three mango varieties (Black Gold, Lemak, and Waterlily) grown in Malaysia were studied by Mirghani et al. 2009 [212]. Kernel samples were extracted to ethanol, methanol, acetone, and phosphate buffer saline and were subjected to antibacterial studies against S. aureus, E. coli, P. aeruginosa and Bacillus subtilis. The results of this study showed that the ethanol and methanol extracts of Lemak have the highest antibacterial potential. Inhibitory effects of methanolic kernel extract (rich in polyphenols) of a Japan M. indica variety against 43 bacterial species have been evaluated by Kabuki et al. 2000 [213]. Methanolic kernel extract of this variety was found to be more active against Gram-positive bacteria in tested organisms.

A number of studies have also been carried out to evaluate antibacterial effects of different extracts of M. indica leaves worldwide. A recent study carried out by Diso et al. 2017 [214] showed that chloroform and aqueous extracts of leaves of an M. indica variety collected in Nigeria possess antibacterial effects against isolates of S. aureus. Chloroform extract of leaves was found to be more inhibitive than the aqueous extracts tested. In vitro antibacterial effects of water, methanol, and acetone extracts of leaves of another M. indica variety grown in Nigeria have been tested on Shigella flexneri, E. coli, S. aureus, Streptococcus pyogenes, Bacillus cereus, P. aeruginosa, Streptococcus pneumoniae, Proteus mirabilis, and Salmonella typhi by Doughari and Manzara, 2008 [215]. Islam et al. 2010 [176] showed the antibacterial effects of leaf ethanol extract of a mango variety found in Bangladesh. Growth inhibition of Staphylococcus aureus, Streptococcus agalactiae, B. cereus, Bacillus megaterium, B. subtilis, and Lactobacillus bulgaricus bacterial species by methanolic leaf extract was observed in the study. An acetone extract of the leaves of an M. indica variety grown in Pakistan exerted a strong inhibition of growth of multidrug resistant S. typhi [216]. Antibacterial effects of several mango leaf extracts grown in India have been proven in several bacterial species by Bharti, 2013 (M. indica variety collected from Rewa district, Madhya Pradesh) [217], Chandrashekar et al. 2014 (mango variety collected from Bhopal, Madhya Pradesh) [218], Madduluri et al., 2013 (collected from Andhra Pradesh) [219], and Sharwat et al., 2013 (collected from Meerut region) [220]. Bhati, 2013 found that hexane and hexane/ethyl acetate extracts of leaves exert promising antibacterial effects against Mycobacterium tuberculosis, Enterobacter aerogenes, and S. pyogenes. Chandrashekar et al. 2014 reported that ethanolic extract of leaves can inhibit the growth of Streptococcus mutans. Methanolic and ethanolic extracts of leaves of M. indica were subjected to antibacterial studies against E. coli, klebsiella pneumoniae, Salmonella typhimurium, S. aureus, and B. cereus in the study conducted by Madduluri et al. 2013. They observed strong inhibitory effects by methanolic and ethanolic extracts against B. cereus. Sharwat et al. 2013 found that methanol, ethanol, and benzene extracts of M. indica leaves can effectively inhibit the growth of Pseudomonas fluorescens. Furthermore, antibacterial effects of ethanolic and methanolic extracts of mango seeds have been subjected to antibacterial effects by Awad El-Gied et al. 2012 [221]. 25 different bacterial strains have been used in this study and out of the 25 strains, Mycobacterium smegmatis showed highest inhibition after exposure to ethanolic and methanolic extracts. Antibacterial effects of mango sap have been determined by Negi et al. 2002 [222]. Aqueous and nonaqueous phases of mango sap obtained from four M. indica varieties (Mallika, Totapuri, Raspuri, and Seedling) have been evaluated for antibacterial activity against S. aureus, E. coli, B. cereus, and P. aeruginosa and the nonaqueous phase of all four M. indica varieties was found to be more inhibitory against B. cereus, whereas aqueous extracts showed no inhibitory effects. A study carried out with pet ether, ethyl acetate, ethanol, and water extracts of roots of the an M. indica variety collected form Karnataka, India, by Latha et al. 2011 [223] has proven antibacterial effects. Ethanol extract of roots of studied M. indica variety was found to be more inhibitory against B. subtilis, E. coli, and K. pneumoniae. Silver nanoparticles (loaded onto nonwoven fabrics) prepared from aqueous extract of mango peel have been subjected to antibacterial effects by Yang and Li, 2013 [224]. The results of this study revealed that prepared nanoparticles can effectively inhibit the growth of E. coli, S. aureus, and B. subtilis. A decoction prepared from ripe and unripe mango peel and seeds has been used to study antibacterial effects by Rakholiya et al. 2013 [225]. Among twenty bacterial species used in this study, Micrococcus flavus was found to be more susceptible to the decoctions prepared from ripe seeds, ripe peel, and unripe seeds. In vitro antibacterial effects of four extracts (aqueous, ethanol, methanol, and acetone) prepared from mango flowers have been studied by Verma et al. 2015 [226] against six pathogenic bacterial strains and methanolic and ethanolic extracts of flowers have shown highest inhibition against S. typhi. Singh et al. 2015 [51] have shown antibacterial effects of bark of a mango variety found in India. Hexane and methanol extracts obtained from Soxhlet extraction of bark have exerted promising antibacterial effects against B. subtilis, S. typhi, P. aeruginosa, E. coli, and S. aureus. Results of antibacterial assays have shown that hexane extract was more active against tested bacterial species. Antibacterial potential of aqueous extract of mango bark has also been carried out by Chidozie et al. 2014 [227]. E. coli, P. aeruginosa, Proteus vulgaris, Streptococcus faecalis, S. typhi, and Shigella have been included in this and results of this study have illustrated that aqueous extract of mango bark was inhibitory to all bacterial species tested except S. faecalis.

5.7. Antifungal Effects of M. indica

Fungal diseases have been identified as an important health problem nowadays [228]. Candida, Aspergillus, and Cryptococcus species are known to causes many fungal diseases worldwide [228]. Candida albicans is reported to be the most common pathogen in fungal infections [229]. Although fungal infections are common, few antifungal drugs are currently used to treat infections [230]. Therefore, the identification of novel drugs as antifungal agents is necessary. Plant-based treatments and natural compounds derived from plants have been identified as ideal drug leads for fungal diseases. A number of pharmacological investigations have confirmed antifungal effects of organic/aqueous extracts of different parts of M. indica. A study was conducted by Muazu et al. 2017 [231] to find antifungal effects of ethanol extract of leaves of an M. indica variety collected in Nigeria. Both extracts tested have shown moderate antifungal effects against Fusarium oxysporum, Fusarium avenaceum, and Pythium aphanidermatum. Moreover, Islam et al. 2010 [176] have evaluated antifungal effects of an ethanolic extract of the leaves of M. indica against three fungal species namely Aspergillus ochraceus, Aspergillus niger, and Aspergillus ustus. Moderate antifungal activity against studied three fungal species has been reported in this study. Antifungal effects of an aqueous extract of leaves of an M. indica variety found in Mexico have been evaluated by Bautista Banos et al. 2002 [232] and results showed a moderate inhibition of fungal strain Colletotrichum gloeosporioides by the aqueous extract. A recent study conducted with seed extracts of four M. indica varieties (Keitt, Sensation, Gomera-3, and peel) found in Spain showed that the extracts inhibited growth of all 18-fungal species tested [233]. Among these species Candida parapsilosis, Candida glabrata, and Lodderomyces elongisporus have exhibited a higher sensitivity towards tested extracts. However, authors have not included the extraction method and type of extracts used to determine antifungal effects. Mango kernel has also been reported to possess antifungal effects. A study carried out by Mutua et al. 2017 [209] has reported methanolic kernel extracts of four mango varieties grown in Kenya (Apple, Ngowe, Sabine, and Kent) exert inhibitory effects against C. albicans. Extracts of Apple, Ngowe, and Sabine showed more inhibitory effects than Kent against C. albicans. Antifungal effects of M. indica bark have also been included in previously mentioned studies [231, 232]. Moderate antifungal activity has been reported for ethanol and methanol extracts [231] and aqueous extract [232] of M. indica bark.

5.8. Anthelmintic Effects of M. indica

Helminth infections which are caused by parasitic worms are commonly seen in tropical regions [234]. They live either as parasites or in some cases in a free-living form [234]. Intestinal nematodes (IN) or soil-transmitted helminths (STH) are the most common types of nematodes [235]. It has been estimated that approximately 30% of world population is primarily infected with helminth parasites annually [236]. Development of resistance to helminth parasites has become a major problem in the treatment of the helminth infections [236]. Hence, discovery of natural remedies that can target helminth infections is important. Anthelmintic effects of extracts of different parts of M. indica have been studies in several in vitro studies. Anthelmintic effects of petroleum ether, ethyl acetate, and ethanol extracts of roots of two M. indica varieties (M. indica L. Var. Thotapuri and M. indica L. Var. Neelam) collected from Karnataka, India, were investigated by Latha et al. 2012 [237]. They showed dose-dependent anthelmintic effects of all three extracts of the two mango varieties used against earthworm Pheretima posthuma with a higher activity for M. indica L. Var. Thotapuri than for M. indica L. Var. Neelam. Sujon et al. 2008 [238] have evaluated anthelmintic effects of an ethanolic extract of roots of an M. indica variety collected from Bangladesh. Moderate anthelmintic effects were seen against adult nematodes collected from the gastrointestinal tract of goats. Anthelmintic effects of aqueous extract of mango fruit against intestinal nematode Strongyloides stercoralis have been studied by El-Sherbini and Osman, 2013 [239]. Aqueous extract of M. indica fruits have shown 100% inhibition of S. stercoralis larval development. A study carried out by García et al. 2003 [240] demonstrated anthelmintic effects of an aqueous extract of bark of M. indica in Trichinella spiralis where significant reduction in parasite larvae and a reduction of serum specific antitrichinellaIgE were reported.

5.9. Antiplasmodial Effects of M. indica

Complete eradication of malaria appears to be a major challenge in the world due to the development of resistance to antimalarial drugs [241]. Many parasites in genus Plasmodium cause malaria and Plasmodium falciparum is the most predominant in genus Plasmodium [242]. It has been estimated that malaria affects approximately 280–290 million people annually [242]. Quinine and artemisinin are naturally derived antimalarial drugs, which have been used for almost 400 years in the treatment of malaria [243]. However, P. falciparum has developed complete resistance to almost all the antimalarial drugs in clinical use [243]. Therefore, it is of paramount importance to investigate novel treatment methods/drugs which can target the malaria parasites. Despite latest inventions of new drugs by pharmaceutical companies, medicinal plants have gained much interest as novel sources for antimalarial drugs. Studies with antiplasmodial effects of mango are limited in literature. A study carried out by Awe et al. 1998 [244] has shown antiplasmodial effects of a bark methanol extract of a mango variety collected from Nigeria. The methanol extract has exhibited significant antiplasmodial effects against malaria parasite, Plasmodium yoelii nigeriensis. Zirihi et al. 2005 [245] have also shown some mild inhibitory effects of an ethanolic extract of mango bark collected from Ivory Coast on P. falciparum. Bidla et al. 2004 [246], on the other hand, have shown that methanol/chloroform extract of leaves of a mango variety collected from India possesses moderate antiplasmodial effects in P. falciparum.

5.10. Antihyperlipemic Effects of M. indica

Hyperlipidemia is considered as a major reason for atherosclerosis and coronary heart disease [247]. Coronary heart disease is the main cause of death in the world [247]. Scientific investigation of herbal remedies for antihyperlipemic effects will give a strong support for the development of drugs for hyperlipidemia. A recent study by Gururaja et al., 2017 [248], reported cholesterol lowering effects of a methanolic extract of M. indica leaves in albino Wistar rats. A significant decrease in plasma cholesterol levels has been observed in rats administrated with cholesterol in this study. Results of the studies conducted with aqueous extracts [249, 250] and ethanolic extracts [251, 252] of M. indica leaves have shown promising antihyperlipemic effects in hyperlipemic rat models. Another study conducted by Vasant and Narasimhacharya, 2011 [253], has reported that feeding of mango fruit powder to hyperlipemic rats can significantly reduce serum cholesterol levels, very low-density lipoproteins (VLDL), and triglycerides (TG). A study conducted by Dineshkumar et al. 2010 [254] with 828 type 2 diabetes patients with high serum cholesterol levels, living in Gopali, India, has shown that consumption of aqueous extract of mango bark can significantly reduce serum total cholesterol level.

5.11. Antidiabetic Effects of M. indica

Diabetes mellitus is a metabolic disease resulting from a defect in insulin action or secretion [255]. It has now become a major health problem affecting 442 million people worldwide [256]. 90% of diabetes cases are type 2 and the remainder is type 1 [257]. Blood glucose homeostasis is the key to prevent diabetes associated complications such as cardiovascular diseases, kidney diseases, eye problems, and peripheral neuropathy [258]. Several plant-based remedies have been used to treat type 2 diabetes in traditional medicine and a number of pharmacological studies have been conducted to validate these claims [259, 260]. Fruit peel, flesh, seed kernel, leaves, and bark of M. indica have been extensively studied for their antidiabetic properties. Gondi and Prasada Rao, 2015 [261] have showed that an ethanolic extract of mango fruit peel can successfully reduce blood glucose level in streptozotocin-induced diabetic rats. Significant decrease in fructosamine and glycated hemoglobin, which are considered as status indicators of diabetes, has also been observed after treatment with the ethanolic extract of mango peel. Another study carried out by Gondi et al. 2015 [262] with M. indica fruit peel powder showed a significant reduction of blood glucose level and diabetes associated complications in rats. Similar results have been obtained in a study carried with a flour prepared from mango fruit pulp [263]. Irondi et al., 2016 [264], showed that flour supplement prepared with mango kernel effectively reduced blood glucose level in diabetes rats. Improvement in liver function, blood glucose level, hepatic glycogen, lipid profile, and hepatic and pancreatic malonaldehyde was observed in diabetic rats supplied with flour supplement.

Several studies on antidiabetic effects of M. indica leaves have been conducted. Antidiabetic efficacy of methanolic leaf extracts of young and matured leaves of M. indica has been evaluated by Mohammed and Rizvi, 2017 [265]. In this study authors found that young leaves were more effective than matured leaves as antidiabetic. Evaluation of antidiabetic effects, by determining inhibition rates of yeast, rat alpha-glucosidase, and porcine pancreatic alpha-amylase, has shown that ethanolic leaf extracts (Thai and Indian mango) have antidiabetic effects [200, 266]. Aderibigbe et al. 1999 [267] found that aqueous extract of M. indica leaves can significantly reduce blood glucose level in streptozotocin-induced diabetic rats. Tanko et al. 2012 [268], Mangola, 1990 [269], Miura et al., 2001 [270], and Waheed et al., 2006 [271], have also proven hypoglycemic effect of aqueous extract of M. indica leaves in diabetic rats. Sharma et al., 1997 [272], have demonstrated hypoglycemic potential of ethanolic extract of mango leaves in normal and streptozotocin-induced diabetic rats. They have successfully shown significant antihyperglycaemic effects in diabetic rats when supplied with ethanolic extract of M. indica leaves. A study conducted by Wadood et al. 2000 [273] found antidiabetic effects of alcoholic extract of the leaves of M. indica in rabbits. Studies carried out with water extracts of M. indica stem-bark by Bhowmik et al., 2009 [274], and Ojewole, 2005 [175], have also proven antihyperglycaemic effects in type 2 diabetic rat model.

5.12. Gastroprotective Effects of M. indica

Peptic ulcers are mainly present in the lining of stomach or in the duodenum [275]. Nonsteroidal anti-inflammatory drugs, mental or physical stress, alcohol, diet, life style, and antibiotics are considered as main causes of peptic ulcers [276]. Peptic ulcers are usually treated with proton pump inhibitors that reduce the secretion of gastric HCl [276]. As peptic ulcer cases are rising at an alarming rate worldwide, it is necessary to discover novel methods or drugs that can effectively reduce peptic ulcers. Assessment of gastroprotective effects of different extracts of M. indica has been carried out. A study conducted by Lima et al. 2006 [277] found that a decoction prepared from M. indica flowers can significantly increase gastroprotective properties in an experimental rat model by reducing gastric juice volume and acidity. Furthermore, Severi et al. 2009 [278] have shown that a decoction prepared from leaves of M. indica reduces gastric lesions induced by HCl, ethanol, and nonsteroidal anti-inflammatory drugs in experimental rat models. Antiulcer potential of ethanol and petroleum ether extracts prepared from mango leaves has also been reported by Neelima et al. 2012 [279]. Akindele et al. 2012 [280] who assessed gastroprotective effects of a drug formulation (DAS-77) which comprises M. indica bark and papaya roots showed a significant reduction of gastric ulcers after feeding with DAS-77 in rat models. Antiulcer activity of an ethanolic extract of mango kernels and in combination with vitamin C, ZnSO_4, and menadione in pylorus ligation and ethanol-induced ulcers in rat models was evaluated by Nethravathi K et al. 2015 [281]. Considerable reduction in gastric volume, ulcer score and index, and total acid output was observed after administration of ethanolic extract and the above drug combinations.

There is a good agreement that exists between pharmacological properties of crude extracts of different parts of M. indica and biological effects of pure compounds isolated from M. indica. Common compounds found in various parts (bark, leaves, and fruits) of M. indica such as mangiferin, derivatives of mangiferin, gallic acid, catechin, quercetin, β-carotene, shikimic acid, and kaempferol have been reported to possess antioxidant effects in several in vitro and in vivo studies [54–58, 61, 62]. Studies that have shown antioxidant effects of crude extracts of M. indica, [73–83], further suggest a striking correlation for the presence of these antioxidant compounds in those tested extracts. Catechin, mangiferin, gallic acid, epigallocatechin gallate, friedelin, humulene, kaempferol, and quercetin are well-known reported anticancer compounds present in mango [54–58, 61, 62]. Available studies that show anticancer effects of different crude extracts (leaves, bark, and fruits), [190–202], strongly correlate the presence of these compounds in crude extracts of M. indica. Alkylresorcinols, epigallocatechin gallate, mangiferin, friedelin, gallic acid, and quercetin have been reported to possess anti-inflammatory effects in various in vitro and in vivo studies [54–58, 61, 62]. Occurrence of these anti-inflammatory compounds in M. indica has been well-documented and reported pharmacological studies which illustrate anti-inflammatory effects [88–98, 166–174] of M. indica’s crude extracts strongly correlate pharmacological effects and chemical composition. Apart from the abovementioned compounds, a large number of chemical compounds have been isolated and reported from different parts (fruits, bark, leaves, flowers, and roots) of M. indica. Some major compounds isolated or identified by gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC-MS) from different parts of mango tree and reported biological effects of those pure compounds have been listed in Table 2. According to the information present in Table 2, it is clear that common mango compounds such as mangiferin, quercetin, catechin, and kaempferol possess a wide range of pharmacological properties.

Conflicts of Interest

The authors have no conflicts of interest.

References

R. Hirano, T. H. Oo, and K. N. Watanabe, “Myanmar mango landraces reveal genetic uniqueness over common cultivars from Florida, India, and Southeast Asia,” Genome, vol. 53, no. 4, pp. 321–330, 2010.
View at: Publisher Site | Google Scholar
V. G. Saúco, “Mango production and world market: Current situation and future prospects,” Acta Horticulturae, vol. 645, pp. 107–116, 2004.
View at: Publisher Site | Google Scholar
C. Torres-León, R. Rojas, J. C. Contreras-Esquivel, L. Serna-Cock, R. E. Belmares-Cerda, and C. N. Aguilar, “Mango seed: Functional and nutritional properties,” Trends in Food Science & Technology, vol. 55, pp. 109–117, 2016.
View at: Publisher Site | Google Scholar
P. V. R. Reddy and K. Sreedevi, “Arthropod communities associated with mango (Mangifera indica L.): diversity and interactions,” in Economic and Ecological Significance of Arthropods in Diversified Ecosystems, pp. 271–298, Springer, Singapore.
View at: Google Scholar
J. Ghuniyal, “Ethanomedical, chemical, pharmacological, toxicological properties of mangifera indica: a review,” International Journal of Pharma Research & Review, vol. 4, no. 10, pp. 51–64, 2015.
View at: Google Scholar
M. Siddiq, S. Akhtar, and R. Siddiq, “Mango processing, products and nutrition,” Tropical and Subtropical Fruits: Postharvest Physiology, Processing and Packaging, pp. 277–297, 2012.
View at: Publisher Site | Google Scholar
C. M. Ajila, S. G. Bhat, and U. J. S. P. Rao, “Valuable components of raw and ripe peels from two Indian mango varieties,” Food Chemistry, vol. 102, no. 4, pp. 1006–1011, 2007.
View at: Publisher Site | Google Scholar
I. Ignat, I. Volf, and V. I. Popa, “A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables,” Food Chemistry, vol. 126, no. 4, pp. 1821–1835, 2011.
View at: Publisher Site | Google Scholar
S. K. Mukherjee, “The mango-its botany, cultivation, uses and future improvement, especially as observed in india,” Economic Botany, vol. 7, no. 2, pp. 130–162, 1953.
View at: Publisher Site | Google Scholar
S. K. Mukherjee, “Origin of mango (Mangifera indica),” Economic Botany, vol. 26, no. 3, pp. 260–264, 1972.
View at: Publisher Site | Google Scholar
B. Slippers, G. I. Johnson, P. W. Crous, T. A. Coutinho, B. D. Wingfield, and M. J. Wingfield, “Phylogenetic and morphological re-evaluation of the Botryosphaeria species causing diseases of Mangifera indica,” Mycologia, vol. 97, no. 1, pp. 99–110, 2005.
View at: Publisher Site | Google Scholar
R. E. Litz, The Mango: Botany, Production And Uses, CABI, 2009.
View at: Publisher Site
D. Nandwani, “Grafting of mango cultivars (Mangifera indica l.) in the u.s. virgin islands,” Their Culture, Environment, and Use, pp. 441–461, 2006.
View at: Google Scholar
A. Nurul Huda, M. R. Che Salmah, A. Abu Hassan, A. Hamdan, and M. N. Abdul Razak, “Pollination services of mango flower pollinators,” Journal of Insect Science, vol. 15, no. 1, article no. 113, 2015.
View at: Publisher Site | Google Scholar
D. Sivakumar, Y. Jiang, and E. M. Yahia, “Maintaining mango (Mangifera indica L.) fruit quality during the export chain,” Food Research International, vol. 44, no. 5, pp. 1254–1263, 2011.
View at: Publisher Site | Google Scholar
G. M. M. Parvez, “Pharmacological activities of mango (Mangifera Indica): A review,” Journal of Pharmacognosy and Phytochemistry, vol. 3, 1 page, 2016.
View at: Google Scholar
N. Wauthoz, A. Balde, E. S. d. Balde, M. Van Damme, and P. Duez, “Ethnopharmacology of Mangifera indica L. bark and pharmacological studies of its main C-glucosylxanthone, mangiferin,” International Journal of Biomedical and Pharmaceutical Sciences, vol. 1, no. 2, pp. 112–119, 2007.
View at: Google Scholar
E. Bekoe, I. Kretchy, J. Sarkodie et al., “Ethnomedicinal survey of plants used for the management of hypertension sold in the makola market, Accra, Ghana,” European Journal of Medicinal Plants, vol. 19, no. 3, pp. 1–9, 2017.
View at: Publisher Site | Google Scholar
C. P. Khare, Indian Medicinal Plants: An Illustrated Dictionary, Springer Science & Business Media, 2008.
C. Williams, “Medicinal Plants in Australia: Plants, Potions and Poisons,” vol. 3, p. 226, Rosenberg Publishing, 2002.
View at: Google Scholar
S. S. Tirtha, “The Ayurveda Encyclopedia,” in Natural Secrets to Healing, Prevention, and Longevity, Sat Yuga Press, 2007.
View at: Google Scholar
T. Agarwal, G. Kochar, and S. Goel, “Impact of iron supplementation on anemia during pregnancy,” Age, vol. 4500, no. 7000, 10 pages, 2008.
View at: Google Scholar
M. S. Khandare, “Mango (Mangifera indica Linn) A medicinal and holy plant,” Journal of Medicinal Plants Studies, vol. 4, no. 4, pp. 44–46, 2016.
View at: Google Scholar
E. U. Etuk, S. O. Bello, S. A. Isezuo, and B. J. Mohammed, “Ethnobotanical survey of medicinal plants used for the treatment of Diabetes mellitus in the north western region of Nigeria,” Asian Journal of Experimental Biological Sciences, vol. 1, no. 1, pp. 55–59, 2010.
View at: Google Scholar
A. C. Ene and S. E. Atawodi, “Ethnomedicinal survey of plants used by the Kanuris of North-eastern Nigeria,” Indian Journal of Traditional Knowledge, vol. 11, no. 4, pp. 640–645, 2012.
View at: Google Scholar
A. H. Memon, F. M. A. Rind, M. G. H. Laghari et al., “Common folk medicinal and ethnomedicinal uses of thirty medicinal plants of districts Dadu and Jamshoro, Sindh, Pakistan,” Sindh University Research Journal (Science Series), vol. 40, no. 2, pp. 89–108, 2008.
View at: Google Scholar
M. F. Nisar, S. Ismail, M. Arshad, A. Majeed, and M. Arfan, “Ethnomedicinal flora of District MandiBahaudin, Pakistan,” Middle-East Journal of Scientific Research, vol. 9, no. 2, pp. 233–238, 2011.
View at: Google Scholar
R. W. Bussmann and D. Sharon, “Traditional medicinal plant use in Northern Peru: Tracking two thousand years of healing culture,” Journal of Ethnobiology and Ethnomedicine, vol. 2, article no. 47, 2006.
View at: Publisher Site | Google Scholar
D. M. A. Jayaweera, Medicinal plants (Indigenous and exotic) used in Ceylon, National Science Council of SriLanka, 1980.
J. C. Barreto, M. T. S. Trevisan, W. E. Hull et al., “Characterization and quantitation of polyphenolic compounds in bark, kernel, leaves, and peel of mango (Mangifera indica L.),” Journal of Agricultural and Food Chemistry, vol. 56, no. 14, pp. 5599–5610, 2008.
View at: Publisher Site | Google Scholar
N. Berardini, R. Fezer, J. Conrad, U. Beifuss, R. Carl, and A. Schieber, “Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin,” Journal of Agricultural and Food Chemistry, vol. 53, no. 5, pp. 1563–1570, 2005.
View at: Publisher Site | Google Scholar
V. Nayan, S. K. Onteru, and D. Singh, “Mangifera indica flower extract mediated biogenic green gold nanoparticles: Efficient nanocatalyst for reduction of 4-nitrophenol,” Environmental Progress & Sustainable Energy, 2017.
View at: Publisher Site | Google Scholar
H. Ichiki, T. Miura, M. Kubo et al., “New antidiabetic compounds, mangiferin and its glucoside,” Biological & Pharmaceutical Bulletin, vol. 21, no. 12, pp. 1389-1390, 1998.
View at: Publisher Site | Google Scholar
X. Ma, H. Wu, L. Liu et al., “Polyphenolic compounds and antioxidant properties in mango fruits,” Scientia Horticulturae, vol. 129, no. 1, pp. 102–107, 2011.
View at: Publisher Site | Google Scholar
I. E. Dreosti, “Antioxidant polyphenols in tea, cocoa, and wine,” Nutrition Journal , vol. 16, no. 7-8, pp. 692–694, 2000.
View at: Publisher Site | Google Scholar
S. M. Rocha Ribeiro, J. H. De Queiroz, M. E. Lopes Ribeiro de Queiroz, F. M. Campos, and H. M. Pinheiro Sant'Ana, “Antioxidant in mango (Mangifera indica L.) pulp,” Plant Foods for Human Nutrition, vol. 62, no. 1, pp. 13–17, 2007.
View at: Publisher Site | Google Scholar
M. Martin and Q. He, “Mango bioactive compounds and related nutraceutical properties-A review,” Food Reviews International, vol. 25, no. 4, pp. 346–370, 2009.
View at: Publisher Site | Google Scholar
I. C. W. Arts, B. Van De Putte, and P. C. H. Hollman, “Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods,” Journal of Agricultural and Food Chemistry, vol. 48, no. 5, pp. 1746–1751, 2000.
View at: Publisher Site | Google Scholar
F. Delgado-Vargas, A. R. Jiménez, and O. Paredes-López, “Natural pigments: carotenoids, anthocyanins, and betalains—characteristics, biosynthesis, processing, and stability,” Critical Reviews in Food Science and Nutrition, vol. 40, no. 3, pp. 173–289, 2000.
View at: Publisher Site | Google Scholar
A. A. Woodall, S. W.-M. Lee, R. J. Weesie, M. J. Jackson, and G. Britton, “Oxidation of carotenoids by free radicals: Relationship between structure and reactivity,” Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1336, no. 1, pp. 33–42, 1997.
View at: Publisher Site | Google Scholar
A. M. Gil, I. F. Duarte, I. Delgadillo et al., “Study of the compositional changes of mango during ripening by use of nuclear magnetic resonance spectroscopy,” Journal of Agricultural and Food Chemistry, vol. 48, no. 5, pp. 1524–1536, 2000.
View at: Publisher Site | Google Scholar
F. B. Jungalwala and H. R. Cama, “Carotenoids in mango (Mangifera indica) fruit,” Indian Journal of Chemistry, vol. 1, no. 1, 36 pages, 1963.
View at: Google Scholar
F. Chen, D. Tholl, J. Bohlmann, and E. Pichersky, “The family of terpene synthases in plants: A mid-size family of genes for specialized metabolism that is highly diversified throughout the kingdom,” The Plant Journal, vol. 66, no. 1, pp. 212–229, 2011.
View at: Publisher Site | Google Scholar
G. Hernández-Sánchez, I. Sanz-Berzosa, V. Casaña-Giner, and E. Primo-Yúfera, “Attractiveness for Ceratitis capitata (Wiedemann) (Dipt., Tephritidae) of mango (Mangifera indica, cv. Tommy Atkins) airborne terpenes,” Journal of Applied Entomology, vol. 125, no. 4, pp. 189–192, 2001.
View at: Publisher Site | Google Scholar
H. J. D. Lalel, Z. Singh, and S. C. Tan, “Aroma volatiles production during fruit ripening of 'Kensington Pride' mango,” Postharvest Biology and Technology, vol. 27, no. 3, pp. 323–336, 2003.
View at: Publisher Site | Google Scholar
G. Ruiz-Montañez, J. A. Ragazzo-Sánchez, M. Calderón-Santoyo, G. Velázquez-De La Cruz, J. A. Ramírez De León, and A. Navarro-Ocaña, “Evaluation of extraction methods for preparative scale obtention of mangiferin and lupeol from mango peels (Mangifera indica L.),” Food Chemistry, vol. 159, pp. 267–272, 2014.
View at: Publisher Site | Google Scholar
C. Engels, M. Knödler, Y.-Y. Zhao, R. Carle, M. G. Gänzle, and A. Schieber, “Antimicrobial activity of gallotannins isolated from mango (Mangifera indica L.) kernels,” Journal of Agricultural and Food Chemistry, vol. 57, no. 17, pp. 7712–7718, 2009.
View at: Publisher Site | Google Scholar
J. D. J. Ornelas-Paz, E. M. Yahia, and A. Gardea-Bejar, “Identification and quantification of xanthophyll esters, carotenes, and tocopherols in the fruit of seven Mexican mango cultivars by liquid chromatography-atmospheric pressure chemical ionization-time-of-flight mass spectrometry [LC-(APcI+)-MS],” Journal of Agricultural and Food Chemistry, vol. 55, no. 16, pp. 6628–6635, 2007.
View at: Publisher Site | Google Scholar
A. Kozubek and J. H. P. Tyman, “Resorcinolic lipids, the natural non-isoprenoid phenolic amphiphiles and their biological activity,” Chemical Reviews, vol. 99, no. 1, pp. 1–26, 1999.
View at: Publisher Site | Google Scholar
M. K. Ediriweera, K. H. Tennekoon, S. R. Samarakoon, A. Adhikari, I. Thabrew, and E. Dilip de Silva, “Isolation of a new resorcinolic lipid from Mangifera zeylanica Hook.f. bark and its cytotoxic and apoptotic potential,” Biomedicine & Pharmacotherapy, vol. 89, pp. 194–200, 2017.
View at: Publisher Site | Google Scholar
R. Singh, S. K. Singh, R. S. Maharia, and A. N. Garg, “Identification of new phytoconstituents and antimicrobial activity in stem bark of Mangifera indica (L.),” Journal of Pharmaceutical and Biomedical Analysis, vol. 105, pp. 150–155, 2015.
View at: Publisher Site | Google Scholar
M. K. Ediriweera, K. H. Tennekoon, A. Adhikari, S. R. Samarakoon, I. Thabrew, and E. D. De Silva, “New halogenated constituents from Mangifera zeylanica Hook.f. and their potential anti-cancer effects in breast and ovarian cancer cells,” Journal of Ethnopharmacology, vol. 189, pp. 165–174, 2016.
View at: Publisher Site | Google Scholar
M. Harwood, B. Danielewska-Nikiel, J. F. Borzelleca, G. W. Flamm, G. M. Williams, and T. C. Lines, “A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties,” Food and Chemical Toxicology, vol. 45, no. 11, pp. 2179–2205, 2007.
View at: Publisher Site | Google Scholar
M. Telang, S. Dhulap, A. Mandhare, and R. Hirwani, “Therapeutic and cosmetic applications of mangiferin: A patent review,” Expert Opinion on Therapeutic Patents, vol. 23, no. 12, pp. 1561–1580, 2013.
View at: Publisher Site | Google Scholar
Jyotshna, P. Khare, and K. Shanker, “Mangiferin: A review of sources and interventions for biological activities,” BioFactors, vol. 42, no. 5, pp. 504–514, 2016.
View at: Publisher Site | Google Scholar
J. M. Calderón-Montaño, E. Burgos-Morón, C. Pérez-Guerrero, and M. López-Lázaro, “A review on the dietary flavonoid kaempferol,” Mini-Reviews in Medicinal Chemistry, vol. 11, no. 4, pp. 298–344, 2011.
View at: Publisher Site | Google Scholar
S. M. R. Ribeiro, L. C. A. Barbosa, J. H. Queiroz, M. Knödler, and A. Schieber, “Phenolic compounds and antioxidant capacity of Brazilian mango (Mangifera indica L.) varieties,” Food Chemistry, vol. 110, no. 3, pp. 620–626, 2008.
View at: Publisher Site | Google Scholar
A. Schieber, N. Berardini, and R. Carle, “Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. cv. “Tommy Atkins”) peels by high-performance liquid chromatography-electrospray ionization mass spectrometry,” Journal of Agricultural and Food Chemistry, vol. 51, no. 17, pp. 5006–5011, 2003.
View at: Publisher Site | Google Scholar
V. Anjaneyulu and P. Radhika, “The triterpenoids and steroids from Mangifera indica Linn,” Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, vol. 39, no. 12, pp. 883–893, 2000.
View at: Google Scholar
K. Shah, M. Patel, R. Patel, and P. Parmar, “Mangifera indica (mango),” Pharmacognosy Reviews, vol. 4, no. 7, pp. 42–48, 2010.
View at: Publisher Site | Google Scholar
P. Scartezzini and E. Speroni, “Review on some plants of Indian traditional medicine with antioxidant activity,” Journal of Ethnopharmacology, vol. 71, no. 1-2, pp. 23–43, 2000.
View at: Publisher Site | Google Scholar
S. Rai, S. Basak, K. Mukherjee, B. Saha, and P. K. Mukherjee, “Oriental medicine mangifera indica,” Oriental Pharmacy and Experimental Medicine, vol. 7, no. 1, pp. 1–10, 2007.
View at: Publisher Site | Google Scholar
S. M. R. Ribeiro and A. Schieber, “Bioactive compounds in mango (Mangifera indica L.),” Bioactive Foods in Promoting Health, pp. 507–523, 2010.
View at: Publisher Site | Google Scholar
Y. Kabir, H. U. Shekhar, and J. S. Sidhu, Phytochemical Compounds in Functional Properties of Mangoes, Handbook of Mango Fruit: Production, Postharvest Science, Processing Technology and Nutrition, 2017.
P. Kalita, “An overview on mangifera indica: importance and its various pharmacological action,” PharmaTutor, vol. 2, no. 12, pp. 72–76, 2014.
View at: Google Scholar
A. Dasgupta, P. Banerjee, and S. Malik, “Use of microwave irradiation for rapid transesterification of lipids and accelerated synthesis of fatty acyl pyrrolidides for analysis by gas chromatography-mass spectrometry: study of fatty acid profiles of olive oil, evening primrose oil, fish oils and phospholipids from mango pulp,” Chemistry and Physics of Lipids, vol. 62, no. 3, pp. 281–291, 1992.
View at: Publisher Site | Google Scholar
M. A. Augustin and E. T. Ling, “Composition of mango seed kernel,” Pertanika, vol. 10, no. 1, pp. 53–59, 1987.
View at: Google Scholar
H. W. Wang, Y. Q. Liu, S. L. Wei, Z. J. Yan, and K. Lu, “Comparison of microwave-assisted and conventional hydrodistillation in the extraction of essential oils from mango (Mangifera indica L.) flowers,” Molecules, vol. 15, no. 11, pp. 7715–7723, 2010.
View at: Publisher Site | Google Scholar
M. Lauricella, S. Emanuele, G. Calvaruso, M. Giuliano, and A. D’Anneo, “Multifaceted health benefits of mangifera indica L. (Mango): The inestimable value of orchards recently planted in sicilian rural areas,” Nutrients, vol. 9, no. 6, 525 pages, 2017.
View at: Publisher Site | Google Scholar
M. Oroian and I. Escriche, “Antioxidants: characterization, natural sources, extraction and analysis,” Food Research International, vol. 74, pp. 10–36, 2015.
View at: Publisher Site | Google Scholar
R. J. Nijveldt, E. van Nood, D. E. C. van Hoorn, P. G. Boelens, K. van Norren, and P. A. M. van Leeuwen, “Flavonoids: a review of probable mechanisms of action and potential applications,” American Journal of Clinical Nutrition, vol. 74, no. 4, pp. 418–425, 2001.
View at: Google Scholar
F. Giampieri, J. M. Alvarez-Suarez, S. Tulipani et al., “Photoprotective potential of strawberry (Fragaria × ananassa) extract against UV-A irradiation damage on human fibroblasts,” Journal of Agricultural and Food Chemistry, vol. 60, no. 9, pp. 2322–2327, 2012.
View at: Publisher Site | Google Scholar
P. A. Thambi, S. John, E. Lydia, P. Iyer, and S. J. Sarah Jane Monica, “Antimicrobial efficacy of mango peel powder and formulation of recipes using mango peel powder (Mangifera indica L.),” nternational Journal of Home Science, vol. 2, pp. 155–161, 2016.
View at: Google Scholar
A. M. Abbasi, F. Liu, X. Guo, X. Fu, T. Li, and R. H. Liu, “Phytochemical composition, cellular antioxidant capacity and antiproliferative activity in mango (Mangifera indica L.) pulp and peel,” International Journal of Food Science & Technology, vol. 52, no. 3, pp. 817–826, 2017.
View at: Publisher Site | Google Scholar
B. Sultana, Z. Hussain, M. Asif, and A. Munir, “Investigation on the antioxidant activity of leaves, peels, stems, bark, and kernel of Mango ( Mangifera indica L.),” Journal of Food Science, vol. 77, no. 8, pp. C849–C852, 2012.
View at: Publisher Site | Google Scholar
H. Kim, J. Y. Moon, H. Kim et al., “Antioxidant and antiproliferative activities of mango (Mangifera indica L.) flesh and peel,” Food Chemistry, vol. 121, no. 2, pp. 429–436, 2010.
View at: Publisher Site | Google Scholar
E. Dorta, M. G. Lobo, and M. Gonzalez, “Reutilization of mango byproducts: study of the effect of extraction solvent and temperature on their antioxidant properties,” Journal of Food Science, vol. 77, no. 1, pp. C80–C88, 2012.
View at: Publisher Site | Google Scholar
A. Septembre-Malaterre, G. Stanislas, E. Douraguia, and M.-P. Gonthier, “Evaluation of nutritional and antioxidant properties of the tropical fruits banana, litchi, mango, papaya, passion fruit and pineapple cultivated in Réunion French Island,” Food Chemistry, vol. 212, pp. 225–233, 2016.
View at: Publisher Site | Google Scholar
K. Afifa, M. Kamruzzaman, I. Mahfuza, H. Afzal, H. Arzina, and H. Roksana, “A comparison with antioxidant and functional properties among five mango (Mangifera indica L.) Varieties in Bangladesh,” International Food Research Journal, vol. 21, no. 4, pp. 1501–1506, 2014.
View at: Google Scholar
G. S. El-Baroty, M. F. Khalil, and S. H. A. Mostafa, “Natural antioxidant ingredient from by-products of fruits,” American journal of Agricultural and Biological Sciences, vol. 9, no. 3, pp. 311–320, 2014.
View at: Publisher Site | Google Scholar
S. Norshazila, I. S. Zahir, K. M. Suleiman, M. R. Aisyah, and K. K. Rahim, “Antioxidant levels and activities of selected seeds of Malaysian tropical fruits,” Malaysian Journal of Nutrition, vol. 16, no. 1, pp. 149–159, 2010.
View at: Google Scholar
M. Pitchaon, “Antioxidant capacity of extracts and fractions from mango (Mangifera indica Linn.) seed kernels,” International Food Research Journal, vol. 18, no. 2, pp. 523–528, 2011.
View at: Google Scholar
C. G. Mohan, M. Deepak, G. L. Viswanatha et al., “Anti-oxidant and anti-inflammatory activity of leaf extracts and fractions of Mangifera indica,” Asian Pacific Journal of Tropical Medicine, vol. 6, no. 4, pp. 311–314, 2013.
View at: Publisher Site | Google Scholar
A. A. Beg and A. S. Baldwin, “The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors,” Genes & Development, vol. 7, no. 11, pp. 2064–2070, 1993.
View at: Google Scholar
F. Mercurio, H. Zhu, B. W. Murray et al., “IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation,” Science, vol. 278, no. 5339, pp. 860–866, 1997.
View at: Publisher Site | Google Scholar
S. Schreiber, S. Nikolaus, and J. Hampe, “Activation of nuclear factor κB inflammatory bowel disease,” Gut, vol. 42, no. 4, pp. 477–484, 1998.
View at: Publisher Site | Google Scholar
S. H. Itzkowitz and X. Yio, “Inflammation and cancer, IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation,” American Journal of Physiology-Gastrointestinal and Liver Physiology, vol. 287, no. 1, pp. G7–G17, 2004.
View at: Publisher Site | Google Scholar
H. Kim, N. Banerjee, R. C. Barnes et al., “Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo,” Molecular Carcinogenesis, vol. 56, no. 1, pp. 197–207, 2016.
View at: Publisher Site | Google Scholar
H. Kim, N. Banerjee, I. Ivanov et al., “Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis,” Molecular Nutrition & Food Research, vol. 60, no. 9, pp. 1912–1923, 2016.
View at: Publisher Site | Google Scholar
L. Márquez, B. G. Pérez-Nievas, I. Gárate et al., “Anti-inflammatory effects of Mangifera indica L. extract in a model of colitis,” World Journal of Gastroenterology, vol. 16, no. 39, pp. 4922–4931, 2010.
View at: Publisher Site | Google Scholar
Y. Jiang, X.-Y. You, K.-L. Fu, and W.-L. Yin, “Effects of extract from Mangifera indica leaf on monosodium urate crystal-induced gouty arthritis in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 967573, 6 pages, 2012.
View at: Publisher Site | Google Scholar
G. Garrido, D. González, Y. Lemus et al., “In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (VIMANG),” Pharmacological Research, vol. 50, no. 2, pp. 143–149, 2004.
View at: Publisher Site | Google Scholar
G. Garrido, D. Gonzalez, C. Delporte et al., “Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang),” Phytotherapy Research, vol. 15, no. 1, pp. 18–21, 2001.
View at: Publisher Site | Google Scholar
G. Garrido, R. Delgado, Y. Lemus, J. Rodríguez, D. García, and A. J. Núñez-Sellés, “Protection against septic shock and suppression of tumor necrosis factor alpha and nitric oxide production on macrophages and microglia by a standard aqueous extract of Mangifera indica L. (VIMANG): role of mangiferin isolated from the extract,” Pharmacological Research, vol. 50, no. 2, pp. 165–172, 2004.
View at: Publisher Site | Google Scholar
G. Martnez, R. Delgado, G. Prez, G. Garrido, A. J. Nez Sells, and O. S. Len, “Evaluation of the in vitro antioxidant activity of Mangifera indica L. extract (Vimang),” Phytotherapy Research, vol. 14, no. 6, pp. 424–427, 2000.
View at: Publisher Site | Google Scholar
S. Siswanto, W. Arozal, V. Juniantito, A. Grace, and F. D. Agustini, “The effect of mangiferin against brain damage caused by oxidative stress and inflammation induced by doxorubicin,” HAYATI Journal of Biosciences, vol. 23, no. 2, pp. 51–55, 2016.
View at: Publisher Site | Google Scholar
J. Wattanathorn, S. Muchimapura, W. Thukham-Mee, K. Ingkaninan, and S. Wittaya-Areekul, “Mangifera indica fruit extract improves memory impairment, cholinergic dysfunction, and oxidative stress damage in animal model of mild cognitive impairment,” Oxidative Medicine and Cellular Longevity, vol. 2014, Article ID 132097, 7 pages, 2014.
View at: Publisher Site | Google Scholar
K. Kawpoomhae, M. Sukma, T. Ngawhirunpat, P. Opanasopit, and A. Sripattanaporn, “Antioxidant and neuroprotective effects of standardized extracts of Mangifera indica leaf,” Thai Journal of Pharmaceutical Sciences, vol. 34, no. 1, pp. 32–43, 2010.
View at: Google Scholar
S. Ahmad, M. A. Sukari, N. Ismail et al., “Phytochemicals from Mangifera pajang Kosterm and their biological activities,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article no. 83, 2015.
View at: Publisher Site | Google Scholar
Y. Semaming, P. Pannengpetch, S. C. Chattipakorn, and N. Chattipakorn, “Pharmacological properties of protocatechuic acid and its potential roles as complementary medicine,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 593902, 2015.
View at: Publisher Site | Google Scholar
I. Naasani, H. Seimiya, and T. Tsuruo, “Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins,” Biochemical and Biophysical Research Communications, vol. 249, no. 2, pp. 391–396, 1998.
View at: Publisher Site | Google Scholar
Y. Zhu, J. Hu, F. Shen, H. Shen, W. Liu, and J. Zhang, “The cytotoxic effect of β-elemene against malignant glioma is enhanced by base-excision repair inhibitor methoxyamine,” Journal of Neuro-Oncology, vol. 113, no. 3, pp. 375–384, 2013.
View at: Publisher Site | Google Scholar
S. Yoshizawa, T. Horiuchi, H. Fujiki, T. Yoshida, T. Okuda, and T. Sugimura, “Antitumor promoting activity of (−)‐epigallocatechin gallate, the main constituent of “Tannin” in green tea,” Phytotherapy Research, vol. 1, no. 1, pp. 44–47, 1987.
View at: Publisher Site | Google Scholar
T. Kalaivani, C. Rajasekaran, and L. Mathew, “Free radical scavenging, cytotoxic, and hemolytic activities of an active antioxidant compound ethyl gallate from leaves of Acacia Nilotica(L.) wild. ex. delile subsp. Indica (Benth.) Brenan,” Journal of Food Science, vol. 76, no. 6, pp. T144–T149, 2011.
View at: Publisher Site | Google Scholar
A. Prabhu, M. K. M. Krishnamoorthy, D. J. Prasad, and P. Naik, “Anticancer activity of friedelin isolated from ethanolic leaf extract of Cassia tora on HeLa and HSC-1 cell lines,” Indian Journal of Applied Research, vol. 3, no. 10, pp. 1–4, 2011.
View at: Publisher Site | Google Scholar
B. Badhani, N. Sharma, and R. Kakkar, “Gallic acid: a versatile antioxidant with promising therapeutic and industrial applications,” RSC Advances, vol. 5, no. 35, pp. 27540–27557, 2015.
View at: Publisher Site | Google Scholar
J. Legault and A. Pichette, “Potentiating effect of β-caryophyllene on anticancer activity of α-humulene, isocaryophyllene and paclitaxel,” Journal of Pharmacy and Pharmacology, vol. 59, no. 12, pp. 1643–1647, 2007.
View at: Publisher Site | Google Scholar
M.-Y. Chang and Y.-L. Shen, “Linalool exhibits cytotoxic effects by activating antitumor immunity,” Molecules, vol. 19, no. 5, pp. 6694–6706, 2014.
View at: Publisher Site | Google Scholar
D. Chaudhuri, N. B. Ghate, S. S. Singh, and N. Mandal, “Methyl gallate isolated from Spondias pinnata exhibits anticancer activity against human glioblastoma by induction of apoptosis and sustained extracellular signal-regulated kinase 1/2 activation,” Pharmacognosy Magazine, vol. 11, no. 42, pp. 269–276, 2015.
View at: Publisher Site | Google Scholar
K. Krishnan, A. Mani, and S. Jasmine, “Cytotoxic activity of bioactive compound 1, 2-benzene Dicarboxylic acid, mono 2-Ethylhexyl Ester extracted from a marine derived Streptomyces sp. VITSJK8,” International Journal of Molecular and Cellular Medicine, vol. 3, pp. 246–254, 2014.
View at: Google Scholar
C. Locatelli, R. Rosso, M. C. Santos-Silva et al., “Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells,” Bioorganic & Medicinal Chemistry, vol. 16, pp. 3791–3799, 2008.
View at: Google Scholar
Y. Nakagawa and S. Tayama, “Cytotoxicity of propyl gallate and related compounds in rat hepatocytes,” Archives of Toxicology, vol. 69, no. 3, pp. 204–208, 1995.
View at: Publisher Site | Google Scholar
J. V. Formica and W. Regelson, “Review of the biology of quercetin and related bioflavonoids,” Food and Chemical Toxicology, vol. 33, no. 12, pp. 1061–1080, 1995.
View at: Publisher Site | Google Scholar
K. D. Croft, “The chemistry and biological effects of flavonoids and phenolic acids,” Annals of the New York Academy of Sciences, vol. 854, pp. 435–442, 1998.
View at: Publisher Site | Google Scholar
J. Ø. Moskaug, H. Carlsen, M. Myhrstad, and R. Blomhoff, “Molecular imaging of the biological effects of quercetin and quercetin-rich foods,” Mechanisms of Ageing and Development, vol. 125, no. 4, pp. 315–324, 2004.
View at: Publisher Site | Google Scholar
A. V. Rao and L. G. Rao, “Carotenoids and human health,” Pharmacological Research, vol. 55, no. 3, pp. 207–216, 2007.
View at: Publisher Site | Google Scholar
V. Anjaneyulu, J. S. Babu, and J. D. Connolly, “29-Hydroxymangiferonic acid fromMangifera indica,” Phytochemistry, vol. 35, no. 5, pp. 1301–1303, 1994.
View at: Publisher Site | Google Scholar
A. J. Núñez Sellés, H. T. Vélez Castro, J. Agüero-Agüero et al., “Isolation and quantitative analysis of phenolic antioxidants, free sugars, and polyols from mango (Mangifera indica L.) stem bark aqueous decoction used in Cuba as a nutritional supplement,” Journal of Agricultural and Food Chemistry, vol. 50, no. 4, pp. 762–766, 2002.
View at: Publisher Site | Google Scholar
K. Tawaha, R. Sadi, F. Qa'dan, K. Z. Matalka, and A. Nahrstedt, “A bioactive prodelphinidin from Mangifera indica leaf extract,” Zeitschrift fur Naturforschung, vol. 65, no. 5-6, pp. 322–326, 2010.
View at: Google Scholar
A. J. Núñez Sellés, M. D. Durruthy Rodríguez, E. R. Balseiro, L. N. González, V. Nicolais, and L. Rastrelli, “Comparison of major and trace element concentrations in 16 varieties of cuban mango stem bark (Mangifera indica L.),” Journal of Agricultural and Food Chemistry, vol. 55, no. 6, pp. 2176–2181, 2007.
View at: Publisher Site | Google Scholar
J. Rodríguez, D. Di Pierro, M. Gioia et al., “Effects of a natural extract from Mangifera indica L, and its active compound, mangiferin, on energy state and lipid peroxidation of red blood cells,” Biochimica et Biophysica Acta (BBA) - General Subjects, vol. 1760, no. 9, pp. 1333–1342, 2006.
View at: Publisher Site | Google Scholar
Y. Y. Soong and P. J. Barlow, “Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity,” Food Chemistry, vol. 97, no. 3, pp. 524–530, 2006.
View at: Publisher Site | Google Scholar
J. P. Munafo, J. Didzbalis, R. J. Schnell, P. Schieberle, and M. Steinhaus, “Characterization of the major aroma-active compounds in mango (Mangifera indica L.) cultivars haden, white alfonso, praya sowoy, royal special, and malindi by application of a comparative aroma extract dilution analysis,” Journal of Agricultural and Food Chemistry, vol. 62, no. 20, pp. 4544–4551, 2014.
View at: Publisher Site | Google Scholar
M. Knödler, J. Conrad, E. M. Wenzig et al., “Anti-inflammatory 5-(11′Z-heptadecenyl)- and 5-(8′Z,11′Z-heptadecadienyl)-resorcinols from mango (Mangifera indica L.) peels,” Phytochemistry, vol. 69, no. 4, pp. 988–993, 2008.
View at: Publisher Site | Google Scholar
Y. Zhong, Y.-S. Chiou, M.-H. Pan, and F. Shahidi, “Anti-inflammatory activity of lipophilic epigallocatechin gallate (EGCG) derivatives in LPS-stimulated murine macrophages,” Food Chemistry, vol. 134, no. 2, pp. 742–748, 2012.
View at: Publisher Site | Google Scholar
P. Antonisamy, V. Duraipandiyan, and S. Ignacimuthu, “Anti-inflammatory, analgesic and antipyretic effects of friedelin isolated from Azima tetracantha Lam. in mouse and rat models,” Journal of Pharmacy and Pharmacology, vol. 63, no. 8, pp. 1070–1077, 2011.
View at: Publisher Site | Google Scholar
E. S. Fernandes, G. F. Passos, R. Medeiros et al., “Anti-inflammatory effects of compounds alpha-humulene and (−)-trans-caryophyllene isolated from the essential oil of Cordia verbenacea,” European Journal of Pharmacology, vol. 569, no. 3, pp. 228–236, 2007.
View at: Publisher Site | Google Scholar
J. Xing, J. Sun, H. You, J. Lv, J. Sun, and Y. Dong, “Anti-inflammatory effect of 3,4-oxo-isopropylidene-shikimic acid on acetic acid-induced colitis in rats,” Inflammation, vol. 35, no. 6, pp. 1872–1879, 2012.
View at: Publisher Site | Google Scholar
G. A. González-Aguilar, C. Y. Wang, J. G. Buta, and D. T. Krizek, “Use of UV-C irradiation to prevent decay and maintain postharvest quality of ripe 'Tommy Atkins' mangoes,” International Journal of Food Science & Technology, vol. 36, no. 7, pp. 767–773, 2001.
View at: Publisher Site | Google Scholar
D. Milenković, J. Dorović, S. Jeremić, J. M. Dimitrić Marković, E. H. Avdović, and Z. Marković, “Free Radical Scavenging Potency of Dihydroxybenzoic Acids,” Journal of Chemistry, vol. 2017, Article ID 5936239, 9 pages, 2017.
View at: Publisher Site | Google Scholar
C. A. Rice-Evans, N. J. Miller, and G. Paganga, “Structure-antioxidant activity relationships of flavonoids and phenolic acids,” Free Radical Biology & Medicine, vol. 20, no. 7, pp. 933–956, 1996.
View at: Publisher Site | Google Scholar
G.-H. Seol, P. Kang, H. S. Lee, and G. H. Seol, “Antioxidant activity of linalool in patients with carpal tunnel syndrome,” BMC Neurology, vol. 16, no. 1, article no. 17, 2016.
View at: Publisher Site | Google Scholar
K. B. Pandey and S. I. Rizvi, “Plant polyphenols as dietary antioxidants in human health and disease,” Oxidative Medicine and Cellular Longevity, vol. 2, no. 5, pp. 270–278, 2009.
View at: Publisher Site | Google Scholar
J. Terao, “Antioxidant activity of β-carotene-related carotenoids in solution,” Lipids, vol. 24, no. 7, pp. 659–661, 1989.
View at: Publisher Site | Google Scholar
H. Palafox-Carlos, E. M. Yahia, and G. A. González-Aguilar, “Identification and quantification of major phenolic compounds from mango (Mangifera indica, cv. Ataulfo) fruit by HPLC-DAD-MS/MS-ESI and their individual contribution to the antioxidant activity during ripening,” Food Chemistry, vol. 135, no. 1, pp. 105–111, 2012.
View at: Publisher Site | Google Scholar
S. George, P. J. Benny, S. Kuriakose, and C. George, “Antibiotic activity of 2, 3-dihydroxybenzoic acid isolated from Flacourtia inermis fruit against multidrug resistant bacteria,” Asian Journal of Pharmaceutical and Clinical Research, vol. 4, no. 1, pp. 126–130, 2011.
View at: Google Scholar
M. Friedman, P. R. Henika, and R. E. Mandrell, “Antibacterial Activities of Phenolic Benzaldehydes and Benzoic Acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica,” Journal of Food Protection, vol. 66, no. 10, pp. 1811–1821, 2003.
View at: Publisher Site | Google Scholar
H. Pal Bais, T. S. Walker, F. R. Stermitz, R. A. Hufbauer, and J. M. Vivanco, “Enantiomeric-dependent phytotoxic and antimicrobial activity of (±)-catechin. A rhizosecreted racemic mixture from spotted knapweed,” Plant Physiology, vol. 128, no. 4, pp. 1173–1179, 2002.
View at: Publisher Site | Google Scholar
S.-N. Park, Y. K. Lim, M. O. Freire, E. Cho, D. Jin, and J.-K. Kook, “Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria,” Anaerobe, vol. 18, no. 3, pp. 369–372, 2012.
View at: Publisher Site | Google Scholar
J.-G. Choi, O.-H. Kang, Y.-S. Lee et al., “In vitro activity of methyl gallate isolated from Galla Rhois alone and in combination with ciprofloxacin against clinical isolates of Salmonella,” Journal of Microbiology and Biotechnology, vol. 18, no. 11, pp. 1848–1852, 2008.
View at: Publisher Site | Google Scholar
R. Kotan, A. Cakir, F. Dadasoglu et al., “Antibacterial activities of essential oils and extracts of Turkish Achillea, Satureja and Thymus species against plant pathogenic bacteria,” Journal of the Science of Food and Agriculture, vol. 90, no. 1, pp. 145–160, 2010.
View at: Publisher Site | Google Scholar
K. Chung, S. E. S. Jr, W. Lin, and C. I. Wei, “Growth inhibition of selected food‐borne bacteria by tannic acid, propyl gallate and related compounds,” Letters in Applied Microbiology, vol. 17, no. 1, pp. 29–32, 1993.
View at: Publisher Site | Google Scholar
B. E. Amborabé, P. Fleurat-Lessard, J. F. Chollet, and G. Roblin, “Antifungal effects of salicylic acid and other benzoic acid derivatives towards Eutypa lata: structure-activity relationship,” Plant Physiology and Biochemistry, vol. 40, no. 12, pp. 1051–1060, 2002.
View at: Publisher Site | Google Scholar
M. Hirasawa and K. Takada, “Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans,” Journal of Antimicrobial Chemotherapy, vol. 53, no. 2, pp. 225–229, 2004.
View at: Publisher Site | Google Scholar
J. Tian, X. Zeng, H. Zeng, Z. Feng, X. Miao, and X. Peng, “Investigations on the antifungal effect of nerol against aspergillus flavus causing food spoilage,” The Scientific World Journal, vol. 2013, Article ID 230795, 2013.
View at: Publisher Site | Google Scholar
S. Ito, Y. Nakagawa, S. Yazawa, Y. Sasaki, and S. Yajima, “Antifungal activity of alkyl gallates against plant pathogenic fungi,” Bioorganic & Medicinal Chemistry Letters, vol. 24, no. 7, pp. 1812–1814, 2014.
View at: Publisher Site | Google Scholar
F. D’Auria, M. Tecca, R. Strippoli, and N. Simonetti, “In vitro activity of propyl gallate-azole drug combination against fluconazole- and itraconazole-resistant Candida albicans strains,” Letters in Applied Microbiology, vol. 32, no. 4, pp. 220–223, 2001.
View at: Publisher Site | Google Scholar
J.-M. Song, K.-H. Lee, and B.-L. Seong, “Antiviral effect of catechins in green tea on influenza virus,” Antiviral Research, vol. 68, no. 2, pp. 66–74, 2005.
View at: Publisher Site | Google Scholar
M. Heng and Z. Lu, “Antiviral effect of mangiferin and isomangiferin on herpes simplex virus,” Chinese Medical Journal, vol. 103, no. 2, pp. 160–165, 1990.
View at: Google Scholar
C. J. M. Kane, J. H. Menna, C.-C. Sung, and Y.-C. Yeh, “Methyl gallate, methyl-3,4,5-trihydroxybenzoate, is a potent and highly specific inhibitor of herpes simplex virus in vitro. II. Antiviral activity of methyl gallate and its derivatives,” Bioscience Reports, vol. 8, no. 1, pp. 95–102, 1988.
View at: Publisher Site | Google Scholar
J. M. Kratz, C. R. Andrighetti-Fröhner, P. C. Leal et al., “Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate,” Biological & Pharmaceutical Bulletin, vol. 31, no. 5, pp. 903–907, 2008.
View at: Publisher Site | Google Scholar
T. Prommajak, S. M. Kim, C.-H. Pan, S. M. Kim, S. Surawang, and N. Rattanapanone, “Identification of antioxidants in young mango leaves by LC-ABTS and LC-MS,” Chiang Mai University Journal of Natural Sciences, vol. 13, no. 3, pp. 317–330, 2014.
View at: Publisher Site | Google Scholar
B. Scazzocchio, R. Varì, C. Filesi et al., “Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin-like effects by upregulating PPARγ activity in human omental adipocytes,” Diabetes, vol. 60, no. 9, pp. 2234–2244, 2011.
View at: Publisher Site | Google Scholar
G. Zheng, K. Sayama, T. Okubo, L. R. Juneja, and I. Oguni, “Anti-obesity effects of three major components of green tea, catechins, caffeine and theanine, in mice,” In Vivo, vol. 18, no. 1, pp. 55–62, 2004.
View at: Google Scholar
V. Duraipandiyan, N. A. Al-Dhabi, S. S. Irudayaraj, and C. Sunil, “Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats,” Revista Brasileira de Farmacognosia, vol. 26, no. 1, pp. 89–93, 2016.
View at: Publisher Site | Google Scholar
R. E. Chapin, T. J. B. Gray, J. L. Phelps, and S. L. Dutton, “The effects of mono-(2-ethylhexyl)-phthalate on rat Sertoli cell-enriched primary cultures,” Toxicology and Applied Pharmacology, vol. 92, no. 3, pp. 467–479, 1988.
View at: Publisher Site | Google Scholar
A. Nakamura, S. Fujiwara, I. Matsumoto, and K. Abe, “Stress repression in restrained rats by (R)-(-)-Linalool inhalation and gene expression profiling of their whole blood cells,” Journal of Agricultural and Food Chemistry, vol. 57, no. 12, pp. 5480–5485, 2009.
View at: Publisher Site | Google Scholar
T. H. C. Marques, M. L. B. G. C. Branco, and D. D. S. L. Marques, “Evaluation of the neuropharmacological properties of nerol in mice,” World Journal of Neuroscience, vol. 3, no. 1, pp. 32–38, 2013.
View at: Publisher Site | Google Scholar
S. Schulz, C. Estrada, S. Yildizhan, M. Boppré, and L. E. Gilbert, “An antiaphrodisiac in Heliconius melpomene butterflies,” Journal of Chemical Ecology, vol. 34, no. 1, pp. 82–93, 2008.
View at: Publisher Site | Google Scholar
A. Conte, S. Pellegrini, and D. Tagliazucchi, “Effect of resveratrol and catechin on PC12 tyrosine kinase activities and their synergistic protection from β-amyloid toxicity,” Drugs under Experimental and Clinical Research, vol. 29, no. 5-6, pp. 243–255, 2003.
View at: Google Scholar
R. Zhu, L. Yang, L. Shen, J. Ye, J. Liu, and S. Hu, “ANG II-AT1 receptor pathway is involved in the anti-fibrotic effect of β-elemene,” Journal of Huazhong University of Science and Technology (Medical Sciences), vol. 29, no. 2, pp. 177–181, 2009.
View at: Publisher Site | Google Scholar
A. Dalman, H. Eimani, H. Sepehri et al., “Effect of mono-(2-ethylhexyl) phthalate (MEHP) on resumption of meiosis, in vitro maturation and embryo development of immature mouse oocytes,” BioFactors, vol. 33, no. 2, pp. 149–155, 2008.
View at: Publisher Site | Google Scholar
F. Barla, H. Higashijima, S. Funai et al., “Inhibitive effects of alkyl gallates on Hyaluronidase and collagenase,” Bioscience, Biotechnology, and Biochemistry, vol. 73, no. 10, pp. 2335–2337, 2009.
View at: Publisher Site | Google Scholar
I. Park, J. Kim, S. Lee, and S. Shin, “Nematicidal activity of plant essential oils and components from Ajowan (Trachyspermum ammi), Allspice (Pimenta dioica) and Litsea (Litsea cubeba) essential oils against pine wood nematode (Bursaphelenchus Xylophilus),” Journal of Nematology, vol. 39, no. 3, pp. 275–279, 2007.
View at: Google Scholar
L. Tang, H. Xiang, Y. Sun et al., “Monopalmityloxy shikimic acid: Enzymatic synthesis and anticoagulation activity evaluation,” Applied Biochemistry and Biotechnology, vol. 158, no. 2, pp. 408–415, 2009.
View at: Publisher Site | Google Scholar
G. Marchesini, M. Brizi, G. Blanchi et al., “Nonalcoholic fatty liver disease: a feature of the metabolic syndrome,” Diabetes, vol. 50, no. 8, pp. 1844–1850, 2001.
View at: Publisher Site | Google Scholar
J. C. FernÃndez-Checa, N. Kaplowitz, A. Colell, and C. GarcÃa-Ruiz, “Oxidative stress and alcoholic liver disease,” Alcohol Research and Health, vol. 21, no. 4, 321 pages, 1997.
View at: Google Scholar
L. P. James, P. R. Mayeux, and J. A. Hinson, “Acetaminophen-induced hepatotoxicity,” Drug Metabolism and Disposition, vol. 31, no. 12, pp. 1499–1506, 2003.
View at: Publisher Site | Google Scholar
Z. Yan and G. W. Caldwell, “Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery,” Current Topics in Medicinal Chemistry, vol. 1, no. 5, pp. 403–425, 2001.
View at: Google Scholar
H. M. Ebeid, A. A. Y. Gibriel, H. M. A. AL-Sayed, S. A. Elbehairy, and E. H. Motawe, “Hepatoprotective and Antioxidant Effects of Wheat, Carrot, and Mango as Nutraceutical Agents against CCl₄-Induced Hepatocellular Toxicity,” Journal of the American College of Nutrition, vol. 34, no. 3, pp. 228–231, 2015.
View at: Publisher Site | Google Scholar
B. D. Hiraganahalli, V. C. Chinampudur, S. Dethe et al., “Hepatoprotective and antioxidant activity of standardized herbal extracts,” Pharmacognosy Magazine, vol. 8, no. 30, pp. 116–123, 2012.
View at: Publisher Site | Google Scholar
S. Prasad, N. Kalra, and Y. Shukla, “Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice,” Molecular Nutrition & Food Research, vol. 51, no. 3, pp. 352–359, 2007.
View at: Publisher Site | Google Scholar
J. Pourahmad, M. R. Eskandari, R. Shakibaei, and M. Kamalinejad, “A search for hepatoprotective activity of fruit extract of mangifera indica L. against oxidative stress cytotoxicity,” Plant Foods for Human Nutrition, vol. 65, no. 1, pp. 83–89, 2010.
View at: Publisher Site | Google Scholar
S. Nithitanakool, P. Pithayanukul, and R. Bavovada, “Antioxidant and hepatoprotective activities of Thai mango seed kernel extract,” Planta Medica, vol. 75, no. 10, pp. 1118–1123, 2009.
View at: Publisher Site | Google Scholar
J. Ojewole, “Antiinflammatory, analgesic and hypoglycemic effects of Mangifera indica Linn. (Anacardiaceae) stem-bark aqueous extract,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 27, no. 8, pp. 547–554, 2005.
View at: Publisher Site | Google Scholar
M. R. Islam, M. A. Mannan, M. H. B. Kabir, A. Islam, and K. J. Olival, “Analgesic, anti-inflammatory and antimicrobial effects of ethanol extracts of mango leaves,” Journal of the Bangladesh Agricultural University, vol. 8, no. 2, pp. 239–244, 2010.
View at: Publisher Site | Google Scholar
M. D. Kazatchkine and S. V. Kaveri, “Immunomodulation of autoimmune and inflammatory diseases with intravenous immune globulin,” The New England Journal of Medicine, vol. 345, no. 10, pp. 747–755, 2001.
View at: Publisher Site | Google Scholar
T. Wegmann, “Foetal protection against abortion: Is it immunosuppression or immunostimulation?” Annales de l'Institut Pasteur/Immunologie, vol. 135, pp. 177–180, 1984.
View at: Publisher Site | Google Scholar
M. A. Dimopoulos and V. Eleutherakis-Papaiakovou, “Adverse effects of thalidomide administration in patients with neoplastic diseases,” American Journal of Medicine, vol. 117, no. 7, pp. 508–515, 2004.
View at: Publisher Site | Google Scholar
G. Garrido, M. Blanco-Molina, R. Sancho, A. Macho, R. Delgado, and E. Muñoz, “An aqueous stem bark extract of Mangifera indica (Vimang®) inhibits T cell proliferation and TNF-induced activation of nuclear transcription factor NF-κB,” Phytotherapy Research, vol. 19, no. 3, pp. 211–215, 2005.
View at: Publisher Site | Google Scholar
J. Leiro, D. García, J. A. Arranz, R. Delgado, M. L. Sanmartín, and F. Orallo, “An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages,” International Immunopharmacology, vol. 4, no. 8, pp. 991–1003, 2004.
View at: Publisher Site | Google Scholar
N. Makare, S. Bodhankar, and V. Rangari, “Immunomodulatory activity of alcoholic extract of Mangifera indica L. in mice,” Journal of Ethnopharmacology, vol. 78, no. 2-3, pp. 133–137, 2001.
View at: Publisher Site | Google Scholar
S. Sahu, B. K. Das, J. Pradhan, B. C. Mohapatra, B. K. Mishra, and N. Sarangi, “Effect of Magnifera indica kernel as a feed additive on immunity and resistance to Aeromonas hydrophila in Labeo rohita fingerlings,” Fish and Shellfish Immunology, vol. 23, no. 1, pp. 109–118, 2007.
View at: Publisher Site | Google Scholar
S. Shailajan, S. Menon, S. Kulkarni, and B. Tiwari, “Standardized extract of Mangifera indica L. leaves as an antimycobacterial and immunomodulatory agent,” Pharmacognosy Communications, vol. 6, no. 3, pp. 137–147, 2016.
View at: Publisher Site | Google Scholar
R. L. Siegel, K. D. Miller, S. A. Fedewa et al., “Colorectal cancer statistics, 2017,” CA: A Cancer Journal for Clinicians, vol. 67, no. 3, pp. 177–193, 2017.
View at: Publisher Site | Google Scholar
C. J. L. Murray and A. D. Lopez, “Mortality by cause for eight regions of the world: global burden of disease study,” The Lancet, vol. 349, no. 9061, pp. 1269–1276, 1997.
View at: Publisher Site | Google Scholar
M. C. Archer, “Cancer-Causing Agents,” Canadian Medical Association Journal, vol. 122, no. 12, p. 1403, 1980.
View at: Google Scholar
World Health, WHO handbook for reporting results of cancer treatment, Geneva: World Health Organization, 1979.
C. J. Dillard and J. Bruce German, “Phytochemicals: nutraceuticals and human health,” Journal of the Science of Food and Agriculture, vol. 80, no. 12, pp. 1744–1756, 2000.
View at: Publisher Site | Google Scholar
H. Kim, H. Kim, A. Mosaddik, R. Gyawali, K. S. Ahn, and S. K. Cho, “Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh,” Food Chemistry, vol. 133, no. 2, pp. 416–422, 2012.
View at: Publisher Site | Google Scholar
A. Corrales-Bernal, L. A. Urango, B. Rojano, and M. E. Maldonado, “In vitro and in vivo effects of mango pulp (Mangifera indica cv. Azucar) in colon carcinogenesis,” Archivos Latinoamericanos de Nutrición, vol. 64, no. 1, pp. 16–23, 2014.
View at: Google Scholar
M.-W. Taing, J.-T. Pierson, P. N. Shaw et al., “Mango fruit extracts differentially affect proliferation and intracellular calcium signalling in MCF-7 human breast cancer cells,” Journal of Chemistry, vol. 2015, Article ID 613268, 2015.
View at: Publisher Site | Google Scholar
N. Banerjee, H. Kim, K. Krenek, S. T. Talcott, and S. U. Mertens-Talcott, “Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: Role of the PI3K/AKT pathway and associated microRNAs,” Nutrition Research, vol. 35, no. 8, pp. 744–751, 2015.
View at: Publisher Site | Google Scholar
G. D. Noratto, M. C. Bertoldi, K. Krenek, S. T. Talcott, P. C. Stringheta, and S. U. Mertens-Talcott, “Anticarcinogenic effects of polyphenolics from mango (Mangifera indica) varieties,” Journal of Agricultural and Food Chemistry, vol. 58, no. 7, pp. 4104–4112, 2010.
View at: Publisher Site | Google Scholar
S. Prasad, N. Kalra, and Y. Shukla, “Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells,” Nutrition and Cancer, vol. 60, no. 1, pp. 120–130, 2007.
View at: Publisher Site | Google Scholar
A. S. Wilkinson, B. M. Flanagan, J.-T. Pierson et al., “Bioactivity of Mango Flesh and Peel Extracts on Peroxisome Proliferator-Activated Receptor γ[PPARγ] Activation and MCF-7 Cell Proliferation: Fraction and Fruit Variability,” Journal of Food Science, vol. 76, no. 1, pp. H11–H18, 2011.
View at: Publisher Site | Google Scholar
A.-S. H. Abdullah, A. S. Mohammed, A. Rasedee, M. E. S. Mirghani, and M. S. Al-Qubaisi, “Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extract,” BMC Complementary and Alternative Medicine, vol. 15, no. 1, article no. 45, 2015.
View at: Publisher Site | Google Scholar
A.-S. H. Abdullah, A. S. Mohammed, A. Rasedee, and M. E. Saeed Mirghani, “Oxidative stress-mediated apoptosis induced by ethanolic mango seed extract in cultured estrogen receptor positive breast cancer MCF-7 cells,” International Journal of Molecular Sciences, vol. 16, no. 2, pp. 3528–3536, 2015.
View at: Publisher Site | Google Scholar
H. X. Nguyen, T. N. V. Do, T. H. Le et al., “Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line,” Journal of Natural Products, vol. 79, no. 8, pp. 2053–2059, 2016.
View at: Publisher Site | Google Scholar
A. Ganogpichayagrai, C. Palanuvej, and N. Ruangrungsi, “Antidiabetic and anticancer activities of Mangifera indica cv. Okrong leaves,” Journal of Advanced Pharmaceutical Technology & Research, vol. 8, no. 1, pp. 19–24, 2017.
View at: Publisher Site | Google Scholar
M. Ediriweera, K. Tennekoon, S. Samarakoon, I. Thabrew, and E. de Silva, “Cytotoxic and apoptotic effects of the bark of two common mango (Mangifera indica) varieties from sri lanka on breast and ovarian cancer cells,” British Journal of Pharmaceutical Research, vol. 10, no. 2, pp. 1–7, 2016.
View at: Publisher Site | Google Scholar
M. K. Ediriweera, K. H. Tennekoon, S. R. Samarakoon, I. Thabrew, and E. D. de Silva, “A study of the potential anticancer activity of Mangifera zeylanica bark: Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay-guided fractionation to identify phytochemical constituents,” Oncology Letters, vol. 11, no. 2, pp. 1335–1344, 2016.
View at: Publisher Site | Google Scholar
M. K. Ediriweera, K. H. Tennekoon, S. R. Samarakoon, I. Thabrew, and E. D. de Silva, “Induction of apoptosis in MCF-7 breast cancer cells by sri lankan endemic mango (Mangifera zeylanica) fruit peel through oxidative stress and analysis of its phytochemical constituents,” Journal of Food Biochemistry, 2016.
View at: Publisher Site | Google Scholar
A. J. Núñez Selles, M. Daglia, and L. Rastrelli, “The potential role of mangiferin in cancer treatment through its immunomodulatory, anti-angiogenic, apoptopic, and gene regulatory effects,” BioFactors, vol. 42, no. 5, pp. 475–491, 2016.
View at: Publisher Site | Google Scholar
S. B. Levy and B. Marshall, “Antibacterial resistance worldwide: causes, challenges and responses,” Nature Medicine, vol. 10, no. 12, pp. S122–S129, 2004.
View at: Publisher Site | Google Scholar
H. C. Neu, “The crisis in antibiotic resistance,” Science, vol. 257, no. 5073, pp. 1064–1073, 1992.
View at: Publisher Site | Google Scholar
S. B. Levy, “Factors impacting on the problem of antibiotic resistance,” Journal of Antimicrobial Chemotherapy, vol. 49, no. 1, pp. 25–30, 2002.
View at: Publisher Site | Google Scholar
H. J. D. Dorman and S. G. Deans, “Antimicrobial agents from plants: antibacterial activity of plant volatile oils,” Journal of Applied Microbiology, vol. 88, no. 2, pp. 308–316, 2000.
View at: Publisher Site | Google Scholar
J. K. Mutua, S. Imathiu, and W. Owino, “Evaluation of the proximate composition, antioxidant potential, and antimicrobial activity of mango seed kernel extracts,” Food Science & Nutrition, vol. 5, no. 2, pp. 349–357, 2017.
View at: Publisher Site | Google Scholar
S. Rajan, T. Thirunalasundari, and S. Jeeva, “Anti-enteric bacterial activity and phytochemical analysis of the seed kernel extract of Mangifera indica Linnaeus against Shigella dysenteriae (Shiga, corrig.) Castellani and Chalmers,” Asian Pacific Journal of Tropical Medicine, vol. 4, no. 4, pp. 294–300, 2011.
View at: Publisher Site | Google Scholar
P. Alok, V. Keerthana, J. C. Kumar, K. Ratan, and A. D. Chand, “Antibacterial property of two different varieties of Indian mango (Mangifera indica) kernel extracts at various concentrations against some human pathogenic bacterial strains, Research Journal of Biological Sciences,” Research Journal of Biological Sciences, vol. 2, pp. 28–32, 2013.
View at: Google Scholar
M. E. S. Mirghani, F. Yosuf, N. A. Kabbashi, J. Vejayan, and Z. B. M. Yosuf, “Antibacterial activity of mango kernel extracts,” Journal of Applied Sciences, vol. 9, no. 17, pp. 3013–3019, 2009.
View at: Publisher Site | Google Scholar
T. Kabuki, H. Nakajima, M. Arai, S. Ueda, Y. Kuwabara, and S. Dosako, “Characterization of novel antimicrobial compounds from mango (Mangifera indica L.) kernel seeds,” Food Chemistry, vol. 71, no. 1, pp. 61–66, 2000.
View at: Publisher Site | Google Scholar
S. Diso, M. Ali, S. Mukhtar, and M. Garba, “Antibacterial activity and phytochemical screening of mangifera indica (Mango) stem and leaf extracts on clinical isolates of methicillin resistant staphylococcus aureus,” Journal of Advances in Medical and Pharmaceutical Sciences, vol. 13, no. 1, pp. 1–6, 2017.
View at: Publisher Site | Google Scholar
J. H. Doughari and S. Manzara, “In vitro antibacterial activity of crude leaf extracts of Mangifera indica Linn,” African Journal of Microbiology Research, vol. 2, no. 4, pp. 67–72, 2008.
View at: Google Scholar
A. Hannan, S. Asghar, T. Naeem et al., “Antibacterial effect of mango (Mangifera indica Linn.) leaf extract against antibiotic sensitive and multi-drug resistant Salmonella typhi,” Pakistan Journal of Pharmaceutical Sciences, vol. 26, no. 4, pp. 715–719, 2013.
View at: Google Scholar
R. P. Bharti, “Studies on antimicrobial activity and phytochemical profile of mangifera indica leaf extract,” IOSR Journal of Environmental Science, Toxicology and Food Technology, vol. 7, no. 3, pp. 74–78, 2013.
View at: Publisher Site | Google Scholar
B. R. Chandrashekar, R. Nagarajappa, R. Singh, and R. Thakur, “An in vitro study on the anti-microbial efficacy of ten herbal extracts on primary plaque colonizers,” Journal of Young Pharmacists, vol. 6, no. 4, pp. 33–39, 2014.
View at: Publisher Site | Google Scholar
S. Madduluri, K. Babu Rao, and B. Sitaram, “In vitro evaluation of antibacterial activity of five indigenous plants extract against five bacterial pathogens of human,” International Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, no. 4, pp. 679–684, 2013.
View at: Google Scholar
A. Sahrawat, S. Pal, and S. K. Shahi, “Antibacterial activity of Mangifera indica (mango) leaves against drug resistant bacterial strains,” in Proceedings of the, vol. 1, pp. 82–86, 2013.
View at: Google Scholar
A. A. Awad El-Gied, M. R. P. Joseph, I. M. Mahmoud, A. M. Abdelkareem, A. M. Al Hakami, and M. E. Hamid, “Antimicrobial activities of seed extracts of mango (Mangifera indica L.),” Advances in Microbiology, vol. 02, no. 04, pp. 571–576, 2012.
View at: Publisher Site | Google Scholar
P. S. Negi, K. Saby John, and U. J. S. Prasada Rao, “Antimicrobial activity of mango sap,” European Food Research and Technology, vol. 214, no. 4, pp. 327–330, 2002.
View at: Publisher Site | Google Scholar
M. S. Latha, K. P. Latha, H. M. Vagdevi, B. S. Virupaxappa, and A. S. Nagashree, “Phytochemical investigation and antibacterial activity of Mangifera indica L. var. Rasapuri root extracts,” International Journal of Medicinal and Aromatic Plants, vol. 1, no. 2, pp. 45–47, 2011.
View at: Google Scholar
N. Yang and W.-H. Li, “Mango peel extract mediated novel route for synthesis of silver nanoparticles and antibacterial application of silver nanoparticles loaded onto non-woven fabrics,” Industrial Crops and Products, vol. 48, pp. 81–88, 2013.
View at: Publisher Site | Google Scholar
K. Rakholiya, M. Kaneria, D. Desai, and S. Chanda, “Antimicrobial activity of decoction extracts of residual parts (seed and peels) of Mangifera indica L. var. Kesar against pathogenic and food spoilage microorganism," Microbial pathogens and strategies for combating them: Science, Technology and Education,” FORMATEX, pp. 850–856, 2013.
View at: Google Scholar
S. K. Verma, S. Yadav, and A. Singh, “In vitro Antibacterial Activity and Phytochemical Analysis of Mangifera indica L flower. Extracts against Pathogenic. Microorganisms,” Journal of Pharmacology & Clinical Toxicology, vol. 3, no. 3, 1053 pages, 2015.
View at: Google Scholar
V. N. Chidozie, G. I. Adoga, O. C. Chukwu, I. D. Chukwu, and A. M. Adekeye, “Antibacterial and toxicological effects of the aqueous extract of mangifera indica stem bark on albino rats,” Global Journal of Biology, Agriculture and Health Sciences, vol. 3, pp. 237–245, 2014.
View at: Google Scholar
G. D. Brown, D. W. Denning, N. A. R. Gow, S. M. Levitz, M. G. Netea, and T. C. White, “Hidden killers: human fungal infections,” Science Translational Medicine, vol. 4, no. 165, 2012.
View at: Publisher Site | Google Scholar
W. R. Jarvis, “Epidemiology of nosocomial fungal infections, with emphasis on Candida species,” Clinical Infectious Diseases, vol. 20, no. 6, pp. 1526–1530, 1995.
View at: Publisher Site | Google Scholar
S. Sternberg, “The emerging fungal threat,” Science, vol. 266, no. 5191, pp. 1632–1634, 1994.
View at: Publisher Site | Google Scholar
U. Muazu, S. Muhammad, and M. T. Muhammad, “Effects of some plant extracts on some selected fungal species,” Journal of Zoological And Bioscience Research, vol. 3, no. 1, 2017.
View at: Google Scholar
S. Bautista Banos, L. L. Barrera Necha, L. Bravo Luna, and K. Berm, “Torres, Antifungal activity of leaf and stem extracts from various plant species on the incidence of Colletotrichum gloeosporioides of papaya and mango fruit after storage,” Mexicana de Fitopatologφa, vol. 20, no. 1, 2002.
View at: Google Scholar
E. Dorta, M. González, M. G. Lobo, and F. Laich, “Antifungal activity of mango peel and seed extracts against clinically pathogenic and food spoilage yeasts,” Natural Product Research (Formerly Natural Product Letters), vol. 30, no. 22, pp. 2598–2604, 2016.
View at: Publisher Site | Google Scholar
J. Bethony, S. Brooker, M. Albonico et al., “Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm,” The Lancet, vol. 367, no. 9521, pp. 1521–1532, 2006.
View at: Publisher Site | Google Scholar
N. R. de Silva, S. Brooker, P. J. Hotez, A. Montresor, D. Engels, and L. Savioli, “Soil-transmitted helminth infections: updating the global picture,” Trends in Parasitology, vol. 19, no. 12, pp. 547–551, 2003.
View at: Publisher Site | Google Scholar
P. H. Gleick, Dirty-Water: Estimated Deaths from Water-Related Diseases 2000-2020, Pacific Institute for Studies in Development, Environment, and Security, Oakland, USA, 2002.
K. P. Latha, M. S. Latha, and H. M. Vagdevi, “Comparative studies on anthelmintic activity of Mangifera indica L. Var. Thotapuri and Mangifera indica L. Var. Neelam root crude extracts,” International Journal of Phytopharmacy, vol. 2, no. 1, pp. 21–24, 2012.
View at: Publisher Site | Google Scholar
M. A. Sujon, M. Mostofa, M. S. Jahan, A. R. Das, and S. Rob, “Studies on medicinal plants against gastroinstestinal nematodes of goats,” Bangladesh Journal of Veterinary Medicine, vol. 6, no. 2, pp. 179–183, 2008.
View at: Publisher Site | Google Scholar
G. T. El-Sherbini and S. M. Osman, “Anthelmintic activity of unripe Mangifera indica L. (Mango) against Strongyloides stercoralis,” International Journal of Current Microbiology and Applied Sciences, vol. 2, no. 5, pp. 401–409, 2013.
View at: Google Scholar
D. García, M. Escalante, R. Delgado, F. M. Ubeira, and J. Leiro, “Anthelminthic and Antiallergic Activities of Mangifera indica L. Stem Bark Components Vimang and Mangiferin,” Phytotherapy Research, vol. 17, no. 10, pp. 1203–1208, 2003.
View at: Publisher Site | Google Scholar
A. P. Dash, N. Valecha, A. R. Anvikar, and A. Kumar, “Malaria in India: challenges and opportunities,” Journal of Biosciences, vol. 33, no. 4, pp. 583–592, 2008.
View at: Publisher Site | Google Scholar
M. J. Gardner, N. Hall, E. Fung et al., “Genome sequence of the human malaria parasite Plasmodium falciparum,” Nature, vol. 419, no. 6906, pp. 498–511, 2002.
View at: Publisher Site | Google Scholar
H. Ginsburg and E. Deharo, “A call for using natural compounds in the development of new antimalarial treatments—an introduction,” Malaria Journal, vol. 10, article S1, supplement 1, 2011.
View at: Publisher Site | Google Scholar
S. O. Awe, O. A. Olajide, O. O. Oladiran, and J. M. Makinde, “Antiplasmodial and antipyretic screening of Mangifera indica extract,” Phytotherapy Research, vol. 12, no. 6, pp. 437-438, 1998.
View at: Publisher Site | Google Scholar
G. N. Zirihi, L. Mambu, F. Guédé-Guina, B. Bodo, and P. Grellier, “In vitro antiplasmodial activity and cytotoxicity of 33 West African plants used for treatment of malaria,” Journal of Ethnopharmacology, vol. 98, no. 3, pp. 281–285, 2005.
View at: Publisher Site | Google Scholar
G. Bidla, V. P. K. Titanji, B. Joko, G. El-Ghazali, A. Bolad, and K. Berzins, “Antiplasmodial activity of seven plants used in African folk medicine,” Indian Journal of Pharmacology, vol. 36, no. 4, pp. 245-246, 2004.
View at: Google Scholar
C. Ricci, M. Gaeta, E. Rausa, Y. Macchitella, and L. Bonavina, “Early impact of bariatric surgery on type ii diabetes, hypertension, and hyperlipidemia: A systematic review, meta-analysis and meta-regression on 6,587 patients,” Obesity Surgery, vol. 24, no. 4, pp. 522–528, 2014.
View at: Publisher Site | Google Scholar
G. M. Gururaja, D. Mundkinajeddu, A. Senthil Kumar, S. M. Dethe, J. Joshua Allan, and A. Agarwal, “Evaluation of cholesterol-lowering activity of standardized extract of Mangifera indica in albino Wistar rats,” Pharmacognosy Research, vol. 9, no. 1, pp. 21–26, 2017.
View at: Publisher Site | Google Scholar
R. M. Y. Morsi, N. R. El-Tahan, and A. M. A. El-Hadad, “Effect of aqueous extract Mangifera indica leaves, as functional foods,” Journal of Applied Sciences Research, vol. 6, no. 6, pp. 712–721, 2010.
View at: Google Scholar
K. A. Shah, M. B. Patel, S. S. Shah, K. N. Chauhan, P. K. Parmar, and N. M. Patel, “Antihyperlipidemic activity of Mangifera indica l. leaf extract on rats fed with high cholesterol diet,” Der Pharmacia Sinica, vol. 1, no. 2, pp. 156–161, 2010.
View at: Google Scholar
M. S. Hossain, M. Ahmed, and A. Islam, “Hypolipidemic and hepatoprotective effects of different fractions of ethanolic extract of immature leaves of Mangifera indica (Linn.) in alloxan induced diabetic rats,” International Journal of Pharmaceutical Sciences and Research, vol. 1, no. 11, p. 132, 2010.
View at: Google Scholar
P. Venkatalakshmi, P. Kemasari, and S. Sangeetha, “Antihyperlipidemic and antioxidant activities of Mangifera Indica Linn., in alloxan induced rats,” International Journal of Pharmaceutical Sciences Review and Research, vol. 11, no. 2, pp. 129–132, 2011.
View at: Google Scholar
R. A. Vasant and A. V. R. L. Narasimhacharya, “Antihyperglycemic and antihyperlipemic effects of Mangifera indica L. in fluoride induced toxicity,” Pharmacologyonline, vol. 3, pp. 265–274, 2011.
View at: Google Scholar
B. Dineshkumar, M. Analava, and M. Manjunatha, “Antidiabetic and hypolipidaemic effects of few common plants extract in type 2 diabetic patients at Bengal,” International Journal of Diabetes and Metabolism, vol. 18, no. 2, pp. 59–65, 2010.
View at: Google Scholar
B. Deepthi, K. Sowjanya, B. Lidiya, R. S. Bhargavi, and P. S. Babu, “A modern review of diabetes mellitus: an annihilatory metabolic disorder,” Journal of In Silico & In Vitro Pharmacology, vol. 3, no. 1:14, pp. 1–5, 2017.
View at: Google Scholar
J. A. Lavery, A. M. Friedman, K. M. Keyes, J. D. Wright, and C. V. Ananth, “Gestational diabetes in the United States: temporal changes in prevalence rates between 1979 and 2010,” BJOG: An International Journal of Obstetrics & Gynaecology, vol. 124, no. 5, pp. 804–813, 2017.
View at: Publisher Site | Google Scholar
Diabetes Prevention Trial–Type 1 Diabetes Study Group, “Effects of insulin in relatives of patients with type 1 diabetes mellitus,” New England journal of Medicine, vol. 2002, no. 346, pp. 1685–1691, 2002.
View at: Google Scholar
K. G. M. M. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, no. 7, pp. 539–553, 1998.
View at: Publisher Site | Google Scholar
C. J. Bailey and C. Day, “Traditional plant medicines as treatments for diabetes,” Diabetes Care, vol. 12, no. 8, pp. 553–564, 1989.
View at: Publisher Site | Google Scholar
M. Barkaoui, A. Katiri, H. Boubaker, and F. Msanda, “Ethnobotanical survey of medicinal plants used in the traditional treatment of diabetes in Chtouka Ait Baha and Tiznit (Western Anti-Atlas), Morocco,” Journal of Ethnopharmacology, vol. 198, pp. 338–350, 2017.
View at: Publisher Site | Google Scholar
M. Gondi and U. J. S. Prasada Rao, “Ethanol extract of mango (Mangifera indica L.) peel inhibits α-amylase and α-glucosidase activities, and ameliorates diabetes related biochemical parameters in streptozotocin (STZ)-induced diabetic rats,” Journal of Food Science and Technology, vol. 52, no. 12, pp. 7883–7893, 2015.
View at: Publisher Site | Google Scholar
M. Gondi, S. A. Basha, J. J. Bhaskar, P. V. Salimath, and U. J. S. Prasada Rao, “Anti-diabetic effect of dietary mango (Mangifera indica L.) peel in streptozotocin-induced diabetic rats,” Journal of the Science of Food and Agriculture, vol. 95, no. 5, pp. 991–999, 2015.
View at: Publisher Site | Google Scholar
G. F. Perpétuo and J. M. Salgado, “Effect of mango (Mangifera indica, L.) ingestion on blood glucose levels of normal and diabetic rats,” Plant Foods for Human Nutrition, vol. 58, no. 3, pp. 1–12, 2003.
View at: Publisher Site | Google Scholar
E. A. Irondi, G. Oboh, and A. A. Akindahunsi, “Antidiabetic effects of Mangifera indica kernel flour-supplemented diet in streptozotocin-induced type 2 diabetes in rats,” Food Science & Nutrition, vol. 4, no. 6, pp. 828–839, 2016.
View at: Publisher Site | Google Scholar
A. Mohammed and S. I. Rizvi, “Anti-diabetic efficacy of young and mature leaf extract of Mangifera indica,” Journal of Traditional Medicines, vol. 12, no. 1, pp. 1–11, 2017.
View at: Google Scholar
B. Dineshkumar, A. Mitra, and M. Manjunatha, “A comparative study of alpha amylase inhibitory activities of common anti-diabetic plants at Kharagpur 1 block,” Journal of Advanced Pharmaceutical Technology & Research, vol. 4, no. 2, pp. 115–121, 2010.
View at: Google Scholar
A. O. Aderibigbe, T. S. Emudianughe, and B. A. S. Lawal, “Antihyperglycaemic effect of Mangifera indica in rat,” Phytotherapy Research, vol. 13, no. 6, pp. 504–507, 1999.
View at: Publisher Site | Google Scholar
Y. Tanko, O. Alladey, M. K. Ahmed, A. Mohammed, and K. Y. Musa, “The effect of methanol leaves extract of Ficus Glumosa on gastrointestinal motility and on castor oil induced diarrhea in laboratory animals,” Journal of Natural Product and Plant Resources, vol. 2, no. 2, pp. 239–243, 2012.
View at: Google Scholar
E. N. Mangola, “Use of traditional medicines in diabetics mellitus,” Diabetics Care, vol. 13, no. 8, 1990.
View at: Google Scholar
T. Miura, H. Ichiki, I. Hashimoto et al., “Antidiabetic activity of a xanthone compound, mangiferin,” Phytomedicine, vol. 8, no. 2, pp. 85–87, 2001.
View at: Publisher Site | Google Scholar
A. Waheed, G. A. Miana, and S. I. Ahmad, “Clinical investigation of hypoglycemic effect of leaves of Mangifera indica in type-2 (NIDDM) diabetes mellitus,” Pakistan Journal of Pharmacology, vol. 23, no. 2, pp. 13–18, 2006.
View at: Google Scholar
S. R. Sharma, S. K. Dwivedi, and D. Swarup, “Hypoglycaemic potential of Mangifera indica leaves in rats,” International Journal of Pharmacognosy, vol. 35, no. 2, pp. 130–133, 1997.
View at: Publisher Site | Google Scholar
N. Wadood, N. Abmad, and A. Wadood, “Effect of Mangifera indica on blood glucose and total lipid levels of normal and alloxan diabetic rabbits,” Pakistan Journal of Medical Research, vol. 39, no. 4, pp. 142–145, 2000.
View at: Google Scholar
A. Bhowmik, L. A. Khan, M. Akhter, and B. Rokeya, “Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats,” Bangladesh Journal of Pharmacology, vol. 4, no. 2, pp. 110–114, 2009.
View at: Publisher Site | Google Scholar
B. J. Marshall and J. R. Warren, “Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration,” The Lancet, vol. 1, no. 8390, pp. 1311–1314, 1984.
View at: Google Scholar
D. J. Stewart and R. Ackroyd, “Peptic ulcers and their complications,” Surgery, vol. 29, no. 11, pp. 568–574, 2011.
View at: Publisher Site | Google Scholar
Z. P. Lima, J. A. Severi, C. H. Pellizzon et al., “Can the aqueous decoction of mango flowers be used as an antiulcer agent?” Journal of Ethnopharmacology, vol. 106, no. 1, pp. 29–37, 2006.
View at: Publisher Site | Google Scholar
J. A. Severi, Z. P. Lima, H. Kushima et al., “Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.),” Molecules, vol. 14, no. 3, pp. 1098–1110, 2009.
View at: Publisher Site | Google Scholar
N. Neelima, M. Sudhakar, M. B. Patil, and B. V. S. Lakshmi, “Anti-ulcer activity and HPTLC analysis of Mangifera indica L. leaves,” International Journal of Pharmaceutical and Phytopharmacological Research, vol. 1, no. 4, pp. 146–155, 2017.
View at: Google Scholar
A. J. Akindele, F. R. Aigbe, J. A. Olowe, B. O. Oduntan, and O. O. Adeyemi, “Gastroprotective effects of DAS-77 (a Phytomedicine) in ulcer models in rats,” Tropical Journal of Pharmaceutical Research, vol. 11, no. 5, pp. 783–791, 2012.
View at: Google Scholar
K. Nethravathi, M. S. Chandrashekhar, T. A. Siddique, and G. Lakshminarayana, “Evaluation of antiulcer activity of Mangifera indica kernel, vitamins and zinc sulphate on pylorus ligation and ethanol induced ulcer models in rats,” International Journal of Phytopharmacology, vol. 6, pp. 86–97, 2015.
View at: Google Scholar

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