Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers

Figure 2

fMRI contrast of the group × time interaction on drug CR-BOLD response. A significant group (MORE, control) × time (Pre, Post) interaction in left ventral striatum (VS: −14, 16, −15) and right vmPFC (10, 20, −10). ’s = 6.7 to 7.9 ’s = 1.57 to 1.7; = 765, ( < 0.05, α = .05, Monte Carlo). Parameter estimates from the model indicate a relative decrease in BOLD response from baseline to 8 weeks post-MORE relative to the control group, who evidenced an increase in BOLD response.