Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised of Morus alba, Scutellaria baicalensis, and Acacia catechu

Table 4

uCTX-II normalized to total protein at week 5.

Group	Dose; (mg/kg)		uCTX-II; (ng/L); (mean ± SD)	Total protein; (g/L); (mean ± SD)	Ratio (CTX-II/protein)	values versus MIA+
Control−	0	5	365 ± 145	3.08 ± 1.02	118.39	0.332
MIA+	0	10	635 ± 233	6.46 ± 2.64	98.30	—
Diclofenac	10	8	304 ± 233	4.72 ± 1.23	64.41	0.017
UP1306	400	10	607 ± 237	7.91 ± 2.57	76.74	0.129
UP446	250	10	614 ± 148	7.56 ± 2.34	81.22	0.103
Composition^†	650	8	489 ± 172	7.66 ± 2.37	63.84	0.003

(i) ^†Composition: UP1306 + UP446; (ii) % inhibition = ((mean treatment − mean MIA)/(mean normal control − mean MIA)) 100.