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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 7236436, 15 pages
https://doi.org/10.1155/2017/7236436
Research Article

Systems Pharmacological Approach to the Effect of Bulsu-san Promoting Parturition

Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongnam 50612, Republic of Korea

Correspondence should be addressed to Won G. An; rk.ca.nasup@nagw

Received 28 July 2017; Accepted 25 September 2017; Published 29 October 2017

Academic Editor: Gihyun Lee

Copyright © 2017 Su Yeon Suh and Won G. An. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Kim and Y. Lee, “The prescriptions of enriching blood and nourishing vital essence (Fill yin blood prescription),” Journal of Korean Medical Classics, vol. 20, pp. 67–77, 2007. View at Google Scholar
  2. Y. Jin, C. Qu, Y. Tang et al., “Herb pairs containing Angelicae Sinensis Radix (Danggui): a review of bio-active constituents and compatibility effects,” Journal of Ethnopharmacology, vol. 181, pp. 158–171, 2016. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Lyu and C. Jeong, “Constitution of prescription and medicinal effect adaptation diseases of 'bullsoosan (berghean)'in korean medical books,” Journal of Korean Medical classics, vol. 29, pp. 17–41, 2016. View at Google Scholar
  4. W. Li, Y. Tang, J. Guo et al., “Enriching blood effect comparison in three kinds of blood deficiency model after oral administration of drug pair of angelicae sinensis radix and chuanxiong rhizoma and each single herb,” China Journal of Chinese Materia Medica, vol. 36, no. 13, pp. 1808–1814, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. W. Li, M. Huang, Y. Tang, J. Guo, E. Shang, and X. Liu, “Establishment and optimization of acute blood stasis rat model,” Chinese Pharmacological Bulletin, vol. 12, p. 032, 2011. View at Google Scholar
  6. Y.-Z. Hou, G.-R. Zhao, Y.-J. Yuan, G.-G. Zhu, and R. Hiltunen, “Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis,” Journal of Ethnopharmacology, vol. 100, no. 1-2, pp. 140–144, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. C. W. C. Bi, L. Xu, X. Y. Tian et al., “Fo Shou San, an ancient chinese herbal decoction, protects endothelial function through increasing endothelial nitric oxide synthase activity,” PLoS ONE, vol. 7, no. 12, Article ID e51670, 2012. View at Publisher · View at Google Scholar · View at Scopus
  8. W. Li, Y. Hua, Y. Tang, H. Wang, L. Qian, and M. Gao, “Effects of radix angelicae sinensis and rhizoma chuanxiong on mouse uterine contractions in vitro,” Journal of Nanjing University of Traditional Chinese Medicine, vol. 2, p. 014, 2010. View at Google Scholar
  9. M. McLean and R. Smith, “Corticotrophin-releasing hormone and human parturition,” Reproduction, vol. 121, no. 4, pp. 493–501, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. S. K. Kota, K. Gayatri, S. Jammula et al., “Endocrinology of parturition,” Indian Journal of Endocrinology and Metabolism, vol. 17, no. 1, pp. 50–59, 2013. View at Publisher · View at Google Scholar
  11. M. Ledingham, A. J. Thomson, I. A. Greer, and J. E. Norman, “Nitric oxide in parturition,” BJOG: An International Journal of Obstetrics & Gynaecology, vol. 107, pp. 581–593, 2000. View at Google Scholar
  12. M. Shen, S. Tian, Y. Li et al., “Drug-likeness analysis of traditional Chinese medicines: 1. property distributions of drug-like compounds, non-drug-like compounds and natural compounds from traditional Chinese medicines,” Journal of Cheminformatics, vol. 4, no. 1, article 31, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. X. Xu, W. Zhang, C. Huang et al., “A novel chemometric method for the prediction of human oral bioavailability,” International Journal of Molecular Sciences, vol. 13, no. 6, pp. 6964–6982, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. I. Hubatsch, E. G. E. Ragnarsson, and P. Artursson, “Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers,” Nature Protocols, vol. 2, no. 9, pp. 2111–2119, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. W. Tao, X. Xu, X. Wang et al., “Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease,” Journal of Ethnopharmacology, vol. 145, no. 1, pp. 1–10, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Zhang, Y. Li, S.-S. Chen et al., “Systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb Folium eriobotryae,” International Journal of Molecular Sciences, vol. 16, no. 2, pp. 2913–2941, 2015. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Willett, J. M. Barnard, and G. M. Downs, “Chemical similarity searching,” Journal of Chemical Information and Computer Sciences, vol. 38, no. 6, pp. 983–996, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Liu, J. Wang, W. Zhou, Y. Wang, and L. Yang, “Systems approaches and polypharmacology for drug discovery from herbal medicines: an example using licorice,” Journal of Ethnopharmacology, vol. 146, no. 3, pp. 773–793, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. K. S. Pang, “Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the gillette review series),” Drug Metabolism & Disposition, vol. 31, no. 12, pp. 1507–1519, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. T. Pei, C. Zheng, C. Huang et al., “Systematic understanding the mechanisms of vitiligo pathogenesis and its treatment by Qubaibabuqi formula,” Journal of Ethnopharmacology, vol. 190, pp. 272–287, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. C. A. Lipinski, F. Lambardo, B. W. Dominy, and P. J. Feeney, “Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings,” Advanced Drug Delivery Reviews, vol. 64, pp. 4–17, 2012. View at Publisher · View at Google Scholar
  22. A. K. Ghose, V. N. Viswanadhan, and J. J. Wendoloski, “Prediction of hydrophobic (lipophilic) properties of small organic molecules using fragmental methods: an analysis of ALOGP and CLOGP methods,” The Journal of Physical Chemistry A, vol. 102, no. 21, pp. 3762–3772, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Rajasethupathy, S. J. Vayttaden, and U. S. Bhalla, “Systems modeling: a pathway to drug discovery,” Current Opinion in Chemical Biology, vol. 9, no. 4, pp. 400–406, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Yu, J. Chen, X. Xu et al., “A systematic prediction of multiple drug-target interactions from chemical, genomic, and pharmacological data,” PLoS ONE, vol. 7, no. 5, Article ID e37608, 2012. View at Publisher · View at Google Scholar · View at Scopus
  25. C. H. Wu, R. Apweiler, A. Bairoch, D. A. Natale, W. C. Barker, B. Boeckmann et al., “The universal protein resource (UniProt): an expanding universe of protein information,” Nucleic Acids Research, vol. 34, pp. D187–D191, 2006. View at Google Scholar · View at MathSciNet
  26. G. Bindea, B. Mlecnik, H. Hackl et al., “ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks,” Bioinformatics, vol. 25, no. 8, pp. 1091–1093, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. E. Smoot, K. Ono, J. Ruscheinski, P. L. Wang, and T. Ideker, “Cytoscape 2.8: new features for data integration and network visualization,” Bioinformatics, vol. 27, no. 3, pp. 431-432, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. J.-B. Pan, S.-C. Hu, D. Shi et al., “PaGenBase: a pattern gene database for the global and dynamic understanding of gene function,” PLoS ONE, vol. 8, no. 12, Article ID e80747, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Zhang, Q. Tao, Z. Guo et al., “Systems pharmacology dissection of the integrated treatment for cardiovascular and gastrointestinal disorders by traditional chinese medicine,” Scientific Reports, vol. 6, p. 32400, 2016. View at Publisher · View at Google Scholar
  30. Z. Prevoršek, G. Gorjanc, B. Paigen, and S. Horvat, “Congenic and bioinformatics analyses resolved a major-effect Fob3b QTL on mouse Chr 15 into two closely linked loci,” Mammalian Genome, vol. 21, no. 3-4, pp. 172–185, 2010. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Du, B. Bai, X. Kuang et al., “Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus,” Journal of Ethnopharmacology, vol. 108, no. 1, pp. 54–58, 2006. View at Publisher · View at Google Scholar · View at Scopus
  32. K. J. Chen and K. Chen, “Ischemic stroke treated with ligusticum chuanxiong,” Chinese Medical Journal, vol. 105, pp. 870–873, 1992. View at Google Scholar
  33. W. Li, J. Guo, Y. Tang et al., “Pharmacokinetic comparison of ferulic acid in normal and blood deficiency rats after oral administration of angelica sinensis, ligusticum chuanxiong and their combination,” International Journal of Molecular Sciences, vol. 13, no. 3, pp. 3583–3597, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Karl, W. Cathy, X. Li, and G. Amy, “Pharmacokinetic analyses of ferulic acid in rat plasma by liquid chromatography?tandem mass spectrometry: a synergistic action of an ancient herbal decoction fo shou san,” Pharmaceutica Analytica Acta, vol. 6, no. 5, p. 2, 2015. View at Publisher · View at Google Scholar
  35. D. Huang, “8 purgative herbs,” Chinese Materia Medica: Chemistry, Pharmacology and Applications, p. 231, 1998. View at Google Scholar
  36. X. Liu, Q. Zhao, C. Li, R. Zhang, X. Wang, and W. Xu, “Synthesis of chuanxiong perlolyrine and its protective effect on injured vascular endothelial cells,” Journal of Shandong University (Health Sciences), vol. 41, pp. 485–487, 2003. View at Google Scholar
  37. J. Ishida, M. Kozuka, H.-K. Wang et al., “Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis,” Cancer Letters, vol. 159, no. 2, pp. 135–140, 2000. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Liu, T. Pei, and J. Mu, “Systems pharmacology uncovers the multiple mechanisms of Xijiao Dihuang decoction for the treatment of viral hemorrhagic fever,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, Article ID 9025036, 17 pages, 2016. View at Publisher · View at Google Scholar
  39. H. Wang and Y. V. Stjernholm, “Plasma membrane receptor mediated MAPK signaling pathways are activated in human uterine cervix at parturition,” Reproductive Biology and Endocrinology, vol. 5, article 3, p. 1, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. S. Mesiano and T. N. Welsh, “Steroid hormone control of myometrial contractility and parturition,” Seminars in Cell & Developmental Biology, vol. 18, no. 3, pp. 321–331, 2007. View at Publisher · View at Google Scholar · View at Scopus
  41. P. W. Nathanielsz, S. L. Jenkins, J. D. Tame, J. A. Winter, S. Guller, and D. A. Giussani, “Local paracrine effects of estradiol are central to parturition in the rhesus monkey,” Nature Medicine, vol. 4, no. 4, pp. 456–459, 1998. View at Publisher · View at Google Scholar · View at Scopus
  42. Y. Li, H. Je, S. Malek, and K. G. Morgan, “ERK1/2-mediated phosphorylation of myometrial caldesmon during pregnancy and labor,” American Journal of Physiology—Regulatory, Integrative and Comparative Physiology, vol. 284, no. 1, pp. R192–R199, 2003. View at Publisher · View at Google Scholar
  43. Y. Li, H.-D. Je, S. Malek, and K. G. Morgan, “Role of ERK1/2 in uterine contractility and preterm labor in rats,” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 287, no. 2, pp. R328–R335, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. S. I. Berger and R. Iyengar, “Network analyses in systems pharmacology,” Bioinformatics, vol. 25, no. 19, pp. 2466–2472, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Li, L.-W. Qi, E.-H. Liu, J.-L. Zhou, and X.-D. Wen, “Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models,” TrAC Trends in Analytical Chemistry, vol. 27, no. 1, pp. 66–77, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. L. M. Espinoza-Fonseca, “The benefits of the multi-target approach in drug design and discovery,” Bioorganic & Medicinal Chemistry, vol. 14, no. 4, pp. 896-897, 2006. View at Publisher · View at Google Scholar · View at Scopus
  47. W. Zhang, Y. Bai, Y. Wang, and W. Xiao, “Polypharmacology in drug discovery: a review from systems pharmacology perspective,” Current Pharmaceutical Design, vol. 22, no. 21, pp. 3171–3181, 2016. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Wray, K. Jones, and S. Kupittayanant, “Calcium signaling and uterine contractility,” Journal of the Society for Gynecologic Investigation, vol. 10, no. 5, pp. 252–264, 2003. View at Publisher · View at Google Scholar · View at Scopus
  49. G. Y. Oudit and Z. Kassiri, “Role of PI3 kinase gamma in excitation-contraction coupling and heart disease,” Cardiovascular and Hematological Disorders, vol. 7, no. 4, pp. 295–304, 2007. View at Publisher · View at Google Scholar · View at Scopus
  50. R. Smith, “Parturition,” The New England Journal of Medicine, vol. 356, no. 3, pp. 271–283, 2007. View at Publisher · View at Google Scholar
  51. S. Y. Suh and W. G. An, “Systems pharmacological approach of pulsatillae radix on treating crohn’s disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2017, Article ID 4198035, 21 pages, 2017. View at Publisher · View at Google Scholar
  52. C. l. Chen and J. Y. Chen, “Analysis on the effect of foshousan combined with ethacridine lactate in mid-term pregnancy,” Journal of Practical Traditional Chinese Medicine, vol. 30, pp. 511-512, 2014. View at Publisher · View at Google Scholar
  53. Y. Sun, “Modified Xiong Gui Tang with auricular acupoint press for 70 cases of late pregnancy,” Guide of China Medicine, vol. 7, no. 20, pp. 92-93, 2009. View at Google Scholar
  54. J.-J. Koksma, J.-M. Fritschy, V. MacK, R. E. Van Kesteren, and A. B. Brussaard, “Differential GABA A receptor clustering determines GABA synapse plasticity in rat oxytocin neurons around parturition and the onset of lactation,” Molecular and Cellular Neuroscience, vol. 28, no. 1, pp. 128–140, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. H. Maul, M. Longo, G. R. Saade, and R. E. Garfield, “Nitric oxide and its role during pregnancy: From ovulation to delivery,” Current Pharmaceutical Design, vol. 9, no. 5, pp. 359–380, 2003. View at Publisher · View at Google Scholar · View at Scopus
  56. M.-J. Ahn, M. K. Lee, Y. C. Kim, and S. H. Sung, “The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 46, no. 2, pp. 258–266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  57. S. Kim, H. Oh, J. Kim, J. Hong, and S. Cho, “A review of pharmacological effects of angelica gigas, angelica sinensis, angelica acutiloba and their bioactive compounds,” The Journal of Korean Oriental Medicine, vol. 32, pp. 1–24, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. J. E. Norman, S. Bollapragada, M. Yuan, and S. M. Nelson, “Inflammatory pathways in the mechanism of parturition,” BMC Pregnancy and Childbirth, vol. 7, supplement 1, article S7, 2007. View at Publisher · View at Google Scholar · View at Scopus