Antiproliferative and Antibacterial Activities of Cirsium scabrum from Tunisia

Table 2

In vitro cytotoxicity of CSPE fractions.

CSPE fractions	WI38; IC50 (µg/ml)	J774; IC50 (µg/ml)	SI; (/IC50 J774)
CSPE1	>20	>20	>1
CSPE2	>20	>20	>1
CSPE3	>20	>20	>1
CSPE4	>20	13.77 ± 1.26
CSPE5	>20	8.96 ± 1.09
CSPE6	>20	>20	>1
CSPE7	>20	>20	>1
Camptothecin	0.175 ± 0.029	0.011 ± 0.002

CSPE1–CSPE7: fractions of CSPE; camptothecin: positive control; results are expressed as mean ± standard error of the mean (SEM) from six determinations and activity differences between cell lines are statistically defined for each fraction with the Mann–Whitney or Wilcoxon signed-rank tests for comparison to the highest tested concentration (, ).