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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 7359806, 7 pages
https://doi.org/10.1155/2017/7359806
Research Article

Rosemary Extracts Upregulate Nrf2, Sestrin2, and MRP2 Protein Level in Human Hepatoma HepG2 Cells

1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province 410011, China
2Hunan University of Chinese Medicine, Changsha, Hunan Province 410208, China
3China Academy of Chinese Medical Sciences, Beijing 100700, China

Correspondence should be addressed to Miao Yan; moc.621@uscoaimnay and Xin-rong Fan; moc.621@3791rxf

Received 9 September 2016; Revised 28 November 2016; Accepted 12 January 2017; Published 13 February 2017

Academic Editor: Alaa Amash

Copyright © 2017 Xiao-pei Tong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. V. Barni, M. J. Carlini, E. G. Cafferata, L. Puricelli, and S. Moreno, “Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells,” Oncology Reports, vol. 27, no. 4, pp. 1041–1048, 2012. View at Publisher · View at Google Scholar
  2. A.-C. Cheng, M.-F. Lee, M.-L. Tsai et al., “Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells,” Food and Chemical Toxicology, vol. 49, no. 2, pp. 485–493, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. V. Krajka-Kuźniak, J. Paluszczak, H. Szaefer, and W. Baer-Dubowska, “The activation of the Nrf2/ARE pathway in HepG2 hepatoma cells by phytochemicals and subsequent modulation of phase II and antioxidant enzyme expression,” Journal of Physiology and Biochemistry, vol. 71, no. 2, pp. 227–238, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. S. L. Ullevig, Q. Zhao, D. Zamora, and R. Asmis, “Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis,” Atherosclerosis, vol. 219, no. 2, pp. 409–416, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. K. Sasaki, A. El Omri, S. Kondo, J. Han, and H. Isoda, “Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation,” Behavioural Brain Research, vol. 238, no. 1, pp. 86–94, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. A.-V. Ferlemi, A. Katsikoudi, V. G. Kontogianni et al., “Rosemary tea consumption results to anxiolytic- and anti-depressant-like behavior of adult male mice and inhibits all cerebral area and liver cholinesterase activity; phytochemical investigation and in silico studies,” Chemico-Biological Interactions, vol. 237, pp. 47–57, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. B. Bozin, N. Mimica-Dukic, I. Samojlik, and E. Jovin, “Antimicrobial and antioxidant properties of Rosemary and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Lamiaceae) essential oils,” Journal of Agricultural and Food Chemistry, vol. 55, no. 19, pp. 7879–7885, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Yesil-Celiktas, C. Sevimli, E. Bedir, and F. Vardar-Sukan, “Inhibitory effects of rosemary extracts, carnosic acid and rosmarinic acid on the growth of various human cancer cell lines,” Plant Foods for Human Nutrition, vol. 65, no. 2, pp. 158–163, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Yan, G. Li, S. M. Petiwala, E. Householter, and J. J. Johnson, “Standardized rosemary (Rosmarinus officinalis) extract induces Nrf2/sestrin-2 pathway in colon cancer cells,” Journal of Functional Foods, vol. 13, pp. 137–147, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. S. M. Petiwala, A. G. Puthenveetil, and J. J. Johnson, “Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer,” Frontiers in Pharmacology, vol. 4, article 29, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. S. M. Petiwala, S. Berhe, G. Li et al., “Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth,” PLoS ONE, vol. 9, no. 3, Article ID e89772, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Januchowski, K. Sterzyńska, K. Zaorska et al., “Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines,” Journal of Ovarian Research, vol. 9, article 65, 2016. View at Publisher · View at Google Scholar