Curcumin Suppresses Intestinal Fibrosis by Inhibition of PPARγ-Mediated Epithelial-Mesenchymal Transition

Figure 4

PPARγ antagonist GW9662 reverses TGF-β1-induced EMT in IEC-6 cells. (a, b) mRNA expression of E-cadherin and α-SMA in IEC-6 cells was analyzed by RT-PCR at the presence of GW9662. , . (c, d) Protein expression of E-cadherin, α-SMA, smad2/3, and p-smad3 in IEC-6 cells was analyzed by Western blotting in the presence of GW9662.

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