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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 7901670, 8 pages
Research Article

Effect of Peony-Glycyrrhiza Decoction on Amisulpride-Induced Hyperprolactinemia in Women with Schizophrenia: A Preliminary Study

1Department of Psychiatry, Brains Hospital of Hunan Province, Changsha, China
2Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha, China

Correspondence should be addressed to Huiyong Huang; moc.621@86yhgnauh and Xuejun Liu; moc.qq@709151707

Received 4 June 2017; Accepted 12 October 2017; Published 26 November 2017

Academic Editor: Nunziatina De Tommasi

Copyright © 2017 Ping Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study is to observe the effect of Peony-Glycyrrhiza Decoction (PGD) on hyperprolactinemia in women with schizophrenia induced by Amisulpride. Material and Methods. A total of 41 female schizophrenia patients receiving Amisulpride were randomly divided into placebo () and PGD groups (). Maintaining the original Amisulpride dose, the two groups were given placebo and PGD, respectively. The levels of Prolactin (PRL) and other hormones were measured on the initial day and at weeks 4 and 8 after treatment. Changes of clinical symptoms in patients with hyperprolactinemia were observed. The PANSS scores were recorded to assess the psychotic symptoms. Results. Compared with placebo group, level of PRL decreased while Progesterone increased remarkably in the PGD group at weeks 4 and 8 (), and level of Estradiol in the PGD group increased significantly at week 8 (). There were no differences in PANSS scores and biochemical indexes between two groups at weeks 4 and 8. Conclusion. PGD can improve symptoms of hyperprolactinemia and hormone levels in women with schizophrenia caused by Amisulpride, without affecting their mental symptoms and biochemical indexes.