Huanglian-Jie-Du-Tang Extract Ameliorates Depression-Like Behaviors through BDNF-TrkB-CREB Pathway in Rats with Chronic Unpredictable Stress

Figure 4

Effects of HJDT on the locomotor activity in OFT after the CUS. Traveled total distance decreased in all rats when exposed to CUS (a). The rearing number decreased in CUS depression group and was reversed with paroxetine and HJDT 2 g/kg treatment (b). The central time and central distance ratio both decreased in CUS depression group and reversed with paroxetine and HJDT (2, 4 g/kg) treatment (c, d). and relative to the normal control group; relative to the CUS depression group. N: normal control group; D: CUS depression group; P: paroxetine group; HJDT 2: HJDT 2 g/kg group; HJDT 4: HJDT 4 g/kg group; HJDT 8: HJDT 8 g/kg group.

(a)

(b)

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