Antileishmanial Activity of Handroanthus serratifolius (Vahl) S. Grose (Bignoniaceae)

Table 1

Antipromastigote activity and cytotoxicity of Handroanthus serratifolius.

Sample	L. amazonensis
	Promastigote; CI50 (µg/mL)	CC50 (µg/mL)	SI
EE	>200	>500	>2.5
FrHex	>200	>500	>2.5
FrDicl	>200	>500	>2.5
FrAcOEt	<100	>500	>5.0
FrMet	>200	>500	>2.5
Lapachol	>200	>500	>2.5
Amphotericin B	>0,390625	>100	256

IC₅₀: inhibitory concentration 50%; CC₅₀: concentration cytotoxic 50%; IS: selectivity index; EE: ethanol extract; FrHex: hexane fraction; FrDcl: dichloromethane fraction; FrAcOEt: ethyl acetate fraction; FrMet: methanol fraction.