Research Article

Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats

Figure 5

Astilbin (GZ-SGR) negatively regulated TLRs-mediated NF-κB signaling. Representative immunoblots and quantitative analysis showed a significant increase protein levels of (a) MyD88, (b) p65, and (c) IKKβ in CFA-induced AA rats, while astilbin treatment alleviated the increase. Data shown represent the mean ± SD of three independent experiments, rats per group as described in Materials and Methods. , versus control group; , , versus CFA-induced arthritic rat model group.