Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 8246420, 10 pages
https://doi.org/10.1155/2017/8246420
Research Article

Astilbin from Smilax glabra Roxb. Attenuates Inflammatory Responses in Complete Freund’s Adjuvant-Induced Arthritis Rats

1School of Pharmacy, Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China
2Center of Miao Medicine Engineering Technology, Guiyang 550002, China
3School of Public Health, Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China
4Department of Epidemiology and Environmental Health, The State University of New York, Buffalo, NY, USA
5School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Correspondence should be addressed to Jinqiu Zhu; ude.olaffub@hzuiqnij and Xiaoyu Chen; kh.ude.ubkh.efil@25466401

Received 7 May 2017; Revised 22 June 2017; Accepted 9 July 2017; Published 22 August 2017

Academic Editor: Subash C. Gupta

Copyright © 2017 Lisha Dong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Jones, P. Nash, and S. Hall, “Advances in rheumatoid arthritis,” The Medical Journal of Australia, vol. 206, no. 5, pp. 221–224, 2017. View at Publisher · View at Google Scholar
  2. P. Geusens and J. Van den Bergh, “Bone erosions in rheumatoid arthritis,” Rheumatology (United Kingdom), vol. 53, no. 1, Article ID ket358, pp. 4-5, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Schett and E. Gravallese, “Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment,” Nature Reviews Rheumatology, vol. 8, no. 11, pp. 656–664, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. C. N. Tran, S. K. Lundy, and D. A. Fox, “Synovial biology and T cells in rheumatoid arthritis,” Pathophysiology, vol. 12, no. 3, pp. 183–189, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. M. J. Fattahi and A. Mirshafiey, “Prostaglandins and Rheumatoid Arthritis,” Arthritis, vol. 2012, pp. 1–7, 2012. View at Publisher · View at Google Scholar
  6. I. B. McInnes and G. Schett, “Cytokines in the pathogenesis of rheumatoid arthritis,” Nature Reviews Immunology, vol. 7, no. 6, pp. 429–442, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Andreakos, S. Sacre, B. M. Foxwell, and M. Feldmann, “The toll-like receptor-nuclear factor κB pathway in rheumatoid arthritis,” Frontiers in Bioscience, vol. 10, no. 2, pp. 2478–2488, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. C. M. Forrest, G. Harman, R. B. McMillan, N. Stoy, T. W. Stone, and L. G. Darlington, “Modulation of cytokine release by purine receptors in patients with rheumatoid arthritis,” Clin Exp Rheumatol, vol. 23, no. 1, pp. 89–92, 2005. View at Google Scholar
  9. H. Okamoto, T. Yoshio, H. Kaneko, and H. Yamanaka, “Inhibition of NF-κB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis,” Arthritis & Rheumatism, vol. 62, no. 1, pp. 82–92, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. X. He, T. Yi, Y. Tang et al., “Assessing the quality of Smilacis Glabrae Rhizoma (Tufuling) by colormetrics and UPLC-Q-TOF-MS,” Chinese Medicine (United Kingdom), vol. 11, no. 1, article no. 33, 2016. View at Publisher · View at Google Scholar · View at Scopus
  11. C. P. Commission, Chinese Pharmacopoeia, vol. 1, Beijing, China, 2015.
  12. G. Hao, J. Zheng, R. Huo et al., “Smilax glabra Roxb targets Aktp-Thr308 and inhibits Akt-mediated signaling pathways in SGC7901 cells,” Journal of Drug Targeting, vol. 24, no. 6, pp. 557–565, 2016. View at Publisher · View at Google Scholar · View at Scopus
  13. T. She, C. Zhao, J. Feng et al., “Sarsaparilla (Smilax Glabra Rhizome) extract inhibits migration and invasion of cancer cells by suppressing TGF-β1 pathway,” PLoS ONE, vol. 10, no. 3, Article ID e0118287, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. G. XX, W. SG, C. XF, H. XC, Z. H, and D. LS, “The comparation of sectioned red and white glabrous greenbrier rhizome in their anti-inflammatory effect”.
  15. J. Jiang and Q. Xu, “Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats,” Journal of Ethnopharmacology, vol. 85, no. 1, pp. 53–59, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Guo, F. Qian, J. Li, Q. Xu, and T. Chen, “Identification of a new metabolite of astilbin, 3′-O-methylastilbin, and its immunosuppressive activity against contact dermatitis,” Clinical Chemistry, vol. 53, no. 3, pp. 465–471, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. Q. Xu, F. Wu, J. Cao et al., “Astilbin selectively induces dysfunction of liver-infiltrating cells - Novel protection from liver damage,” European Journal of Pharmacology, vol. 377, no. 1, pp. 93–100, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Chen, J. Li, J. Cao, Q. Xu, K. Komatsu, and T. Namba, “A new flavanone isolated from rhizoma Smilacis glabrae and the structural requirements of its derivatives for preventing immunological hepatocyte damage,” Planta Medica, vol. 65, no. 1, pp. 56–59, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. Q.-F. Zhang and H.-Y. Cheung, “The content of astilbin and taxifolin in concentrated extracts of Rhizoma Smilacis Glabrae and turtle jelly vary significantly,” Food Chemistry, vol. 119, no. 3, pp. 907–912, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. Z.-C. Zhang, S.-J. Zhang, B. Jin et al., “Ciclamilast ameliorates adjuvant-induced arthritis in a rat model,” BioMed Research International, vol. 2015, Article ID 786104, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. R.-Z. Zhu, D. Xiang, C. Xie et al., “Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice,” World Journal of Gastroenterology, vol. 16, no. 22, pp. 2771–2779, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. E. Lubberts and W. B. van den Berg, “Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis,” Advances in Experimental Medicine and Biology, vol. 520, pp. 194–202.
  23. J. A. Roman-Blas and S. A. Jimenez, “Targeting NF-κB: A promising molecular therapy in inflammatory arthritis,” International Reviews of Immunology, vol. 27, no. 5, pp. 351–374, 2008. View at Publisher · View at Google Scholar · View at Scopus
  24. S. S. Makarov, “NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction,” Arthritis Research, vol. 3, no. 4, pp. 200–206, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Wang, X. Yang, J. Zhao, C. Lu, and W. Zhu, “Structural characterization and macrophage immunomodulatory activity of a novel polysaccharide from Smilax glabra Roxb.,” Carbohydrate Polymers, vol. 156, pp. 390–402, 2017. View at Publisher · View at Google Scholar
  26. P. B. Galhena, S. R. Samarakoon, and M. I. Thabrew, “Anti-inflammatory activity is a possible mechanism by which the polyherbal formulation comprised of Nigella sativa (seeds), Hemidesmus indicus (root), and Smilax glabra (rhizome) mediates its antihepatocarcinogenic effects,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 108626, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. C.-L. Lu, Y.-F. Zhu, M.-M. Hu et al., “Optimization of astilbin extraction from the rhizome of smilax glabra, and evaluation of its anti-inflammatory effect and probable underlying mechanism in lipopolysaccharide-induced raw264.7 macrophages,” Molecules, vol. 20, no. 1, pp. 625–644, 2015. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Yan and Q. Xu, “Astilbin selectively facilitates the apoptosis of interleukin-2-dependent phytohemagglutinin-activated Jurkat cells,” Pharmacological Research, vol. 44, no. 2, pp. 135–139, 2001. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Fei, X. Wu, and Q. Xu, “Astilbin inhibits contact hypersensitivity through negative cytokine regulation distinct from cyclosporin A,” Journal of Allergy and Clinical Immunology, vol. 116, no. 6, pp. 1350–1356, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Cai, T. Chen, and Q. Xu, “Astilbin suppresses collagen-induced arthritis via the dysfunction of lymphocytes,” Inflammation Research, vol. 52, no. 8, pp. 334–340, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. L. Guo, W. Liu, T. Lu et al., “Decrease of functional activated T and B cells and treatment of glomerulonephitis in lupus-prone mice using a natural flavonoid astilbin,” PLoS ONE, vol. 10, no. 4, Article ID e0124002, 2015. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Emery, F. C. Breedveld, E. M. Lemmel et al., “A comparison of the efficacy and safety of leflunomide and methotrexate for the treatment of rheumatoid arthritis,” Rheumatology, vol. 39, no. 6, pp. 655–665, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. M. C. Kraan, R. J. Reece, T. J. M. Smeets, D. J. Veale, P. Emery, and P. P. Tak, “Comparison of synovial tissues from the knee joints and the small joints of rheumatoid arthritis patients: Implications for pathogenesis and evaluation of treatment,” Arthritis and Rheumatism, vol. 46, no. 8, pp. 2034–2038, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. S. H. Venkatesha, R. Rajaiah, B. M. Berman, and K. D. Moudgil, “Immunomodulation of autoimmune arthritis by herbal CAM,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 986797, 13 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. P. F. Zangerle, D. De Groote, M. Lopez et al., “Direct stimulation of cytokines (IL-1β, TNF-α, IL-6, IL-2, IFN-γ and GM-CSF) in whole blood: II. Application to rheumatoid arthritis and osteoarthritis,” Cytokine, vol. 4, no. 6, pp. 568–575, 1992. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Y. Md Yusof and P. Emery, “Targeting interleukin-6 in rheumatoid arthritis,” Drugs, vol. 73, no. 4, pp. 341–356, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. S. Srirangan and E. H. Choy, “The role of Interleukin 6 in the pathophysiology of rheumatoid arthritis,” Therapeutic Advances in Musculoskeletal Disease, vol. 2, no. 5, pp. 247–256, 2010. View at Publisher · View at Google Scholar · View at Scopus
  38. C. J. Edwards, “Immunological therapies for rheumatoid arthritis,” British Medical Bulletin, vol. 73-74, pp. 71–82, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Hennigan and A. Kavanaugh, “Interleukin-6 inhibitors in the treatment of rheumatoid arthritis,” Therapeutics and Clinical Risk Management, vol. 4, no. 4, pp. 767–775, 2008. View at Publisher · View at Google Scholar · View at Scopus
  40. T. H. Mogensen, “Pathogen recognition and inflammatory signaling in innate immune defenses,” Clinical Microbiology Reviews, vol. 22, no. 2, pp. 240–273, 2009. View at Publisher · View at Google Scholar
  41. T. Lawrence, “The nuclear factor NF-κB pathway in inflammation,” Cold Spring Harbor perspectives in biology, vol. 1, no. 6, Article ID a001651, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Alexopoulou, A. C. Holt, R. Medzhitov, and R. A. Flavell, “Recognition of double-stranded RNA and activation of NF-κB by toll-like receptor 3,” Nature, vol. 413, no. 6857, pp. 732–738, 2001. View at Publisher · View at Google Scholar · View at Scopus
  43. R. M. Pope and Q.-Q. Huang, “The role of Toll-like receptors in rheumatoid arthritis,” Current Rheumatology Reports, vol. 11, no. 5, pp. 357–364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. J. A. Roman-Blas and S. A. Jimenez, “NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis,” Osteoarthritis and Cartilage, vol. 14, no. 9, pp. 839–848, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. P. Bamborough, M. A. Morse, and K. P. Ray, “Targeting IKKbeta for the treatment of rheumatoid arthritis,” Drug News Perspect, vol. 23, no. 8, pp. 483–490, 2010. View at Google Scholar
  46. M. Sioud, O. Mellbye, and O. Forre, “Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA”.
  47. C. Lianxu, J. Hongti, and Y. Changlong, “NF-κBp65-specific siRNA inhibits expression of genes of COX-2, NOS-2 and MMP-9 in rat IL-1β-induced and TNF-α-induced chondrocytes,” Osteoarthritis and Cartilage, vol. 14, no. 4, pp. 367–376, 2006. View at Publisher · View at Google Scholar · View at Scopus