Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 8248142, 9 pages
https://doi.org/10.1155/2017/8248142
Research Article

Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS-Stimulated RAW264.7 Cells through Suppression of NF-κB/MAPK Signaling Pathway

1College of Animal Science and Technology, Anhui Agricultural University, 130 West Changjiang Road, Hefei 230036, China
2Institute of Animal Husbandry and Veterinary Medicine, Anhui Academy of Agriculture Sciences, Nongkenan Road, Hefei 230031, China

Correspondence should be addressed to Jinjie Wu; nc.ude.uaha@jjw

Received 24 January 2017; Revised 16 March 2017; Accepted 11 April 2017; Published 6 June 2017

Academic Editor: Emilio Lizarraga

Copyright © 2017 Yu Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Levine, N. Mizushima, and H. W. Virgin, “Autophagy in immunity and inflammation,” Nature, vol. 469, no. 7330, pp. 323–335, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. F. Li, D. Liang, Z. Yang et al., “Astragalin suppresses inflammatory responses via down-regulation of NF-κB signaling pathway in lipopolysaccharide-induced mastitis in a murine model,” International Immunopharmacology, vol. 17, no. 2, pp. 478–482, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. X. P. Li, C. L. Zhang, P. Gao, J. Gao, and D. Liu, “Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats,” Drug Research, vol. 63, no. 5, pp. 258–262, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Varma, H. Padh, and N. Shrivastava, “Andrographolide: a new plant-derived antineoplastic entity on horizon,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 815390, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Zhu, D. X. Wang, W. Zhang et al., “Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB,” PLoS ONE, vol. 8, no. 2, Article ID e56407, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. C. V. Chandrasekaran, P. Thiyagarajan, H. B. Deepak, and A. Agarwal, “In vitro modulation of LPS/calcimycin induced inflammatory and allergic mediators by pure compounds of Andrographis paniculata (King of bitters) extract,” International Immunopharmacology, vol. 11, no. 1, pp. 79–84, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. J.-M. Zhang and J. An, “Cytokines, inflammation, and pain,” International Anesthesiology Clinics, vol. 45, no. 2, pp. 27–37, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. X. Jin, S. N. Shi, and D. F. Zhang, “Study on composition of andrographolide,” Chinese Herbal Medicines, vol. 43, pp. 47–50, 2014. View at Google Scholar
  9. M. Rossol, H. Heine, U. Meusch et al., “LPS-induced cytokine production in human monocytes and macrophages,” Critical Reviews in Immunology, vol. 31, pp. 379–446, 2011. View at Publisher · View at Google Scholar · View at Scopus
  10. A. A. Abu-Ghefreh, H. Canatan, and C. I. Ezeamuzie, “In vitro and in vivo anti-inflammatory effects of andrographolide,” International Immunopharmacology, vol. 9, no. 3, pp. 313–318, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. S. H. Diks, D. J. Richel, and M. P. Peppelenbosch, “LPS signal transduction: the picture is becoming more complex,” Current Topics in Medicinal Chemistry, vol. 4, no. 11, pp. 1115–1126, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. Z. Meng, C. Yan, Q. Deng, D.-F. Gao, and X.-L. Niu, “Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-κB pathways,” Acta Pharmacologica Sinica, vol. 34, no. 7, pp. 901–911, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. L.-H. Qin, Z.-W. Zheng, L. Kong, J. Lü, Y.-X. Shi, and Y.-P. Li, “Andrographolide inhibits expression of TNF-α and IL-12 in activated macrophages,” Academic Journal of Second Military Medical University, vol. 32, no. 7, pp. 717–720, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. D. Talei, A. Valdiani, M. Maziah, S. R. Sagineedu, and R. Abiri, “Salt stress-induced protein pattern associated with photosynthetic parameters and andrographolide content in Andrographis paniculata Nees,” Bioscience, Biotechnology and Biochemistry, vol. 79, no. 1, pp. 51–58, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Du, X. Niu, and H. Y. Li, “Andrographolide microemulsion anti-inflammatory effects,” Chinese Journal of Traditional Medicine, pp. 94–96, 2012. View at Google Scholar
  16. Y. F. Xia, B. Q. Ye, Y. D. Li et al., “Andrographolide attenuates inflammation by inhibition of NF-kB activation through covalent modification of reduced cysteine,” Journal of Immunology, vol. 173, no. 6, pp. 4207–4217, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Batkhuu, K. Hattori, F. Takano et al., “Suppression of NO production in activated macrophages in vitro and ex vivo by neoandrographolide isolated from Andrographis paniculata,” Biological & Pharmaceutical Bulletin, vol. 25, pp. 1169–1174, 2002. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Amroyan, E. Gabrielian, A. Panossian, G. Wikman, and H. Wagner, “Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation,” Phytomedicine, vol. 6, no. 1, pp. 27–31, 1999. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Puri, R. Saxena, R. P. Saxena, K. C. Saxena, V. Srivastava, and J. S. Tandon, “Immunostimulant agents from Andrographis paniculata,” Journal of Natural Products, vol. 56, no. 7, pp. 995–999, 1993. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. C. Shen, C. F. Chen, and W. F. Chiou, “Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect,” British Journal of Pharmacology, vol. 135, no. 2, pp. 399–406, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. Y.-C. Shen, C.-F. Chen, and W.-F. Chiou, “Suppression of rat neutrophil reactive oxygen species production and adhesion by the diterpenoid lactone andrographolide,” Planta Medica, vol. 66, no. 4, pp. 314–317, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Kapil, I. B. Koul, S. K. Banerjee, and B. D. Gupta, “Antihepatoxic effects of major diterpenoid constituents of Andrographis paniculata,” Biochemical Pharmacology, vol. 46, no. 1, pp. 182–185, 1993. View at Publisher · View at Google Scholar · View at Scopus
  23. X. Zeng, H. C. Bi, and M. Huang, “Research progress of drug control in the process of inflammatory reaction,” Acta Pharmacologica Sinica, vol. 7, pp. 773–779, 2011. View at Google Scholar
  24. P. Rainard and C. Riollet, “Innate immunity of the bovine mammary gland,” Veterinary Research, vol. 37, no. 3, pp. 369–400, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Takeda and S. Akira, “TLR signaling pathways,” Seminars in Immunology, vol. 16, no. 1, pp. 3–9, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. Q.-Q. Zhang, Y. Ding, Y. Lei et al., “Andrographolide suppress tumor growth by inhibiting TLR4/NF-kB signaling activation in insulinoma,” International Journal of Biological Sciences, vol. 10, no. 4, pp. 404–414, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. M. Yamamoto, S. Sato, H. Hemmi et al., “Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4,” Nature, vol. 420, no. 6913, pp. 324–329, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. J. C. Rosa, F. S. Lira, R. Eguchi et al., “Exhaustive exercise increases inflammatory response via toll like receptor-4 and NF-κBp65 pathway in rat adipose tissue,” Journal of Cellular Physiology, vol. 226, no. 6, pp. 1604–1607, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. H.-Y. Kim, K. W. Hwang, and S.-Y. Park, “Extracts of Actinidia arguta stems inhibited LPS-induced inflammatory responses through nuclear factor-κB pathway in Raw 264.7 cells,” Nutrition Research, vol. 34, no. 11, pp. 1008–1016, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. L. Koch, D. Frommhold, K. Buschmann, N. Kuss, J. Poeschl, and P. Ruef, “LPS- and LTA-induced expression of IL-6 and TNF-α in neonatal and adult blood: role of MAPKs and NF-κB,” Mediators of Inflammation, vol. 2014, Article ID 283126, 8 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus