Optimal Solubility of Diclofenac β-Cyclodextrin in Combination with Local Anaesthetics for Mesotherapy Applications

Figure 1

Representative images of a turbid (a), a milky (b), and a limpid solution (c). Volume of each mixture is reported in brackets.

(a) Turbid solution: Akis 50 mg/mL + lidocaine 1% (1 mL) + normal saline (3 mL)

(b) Milky solution: Akis 50 mg/mL + lidocaine 1% (1 mL) + sterile water for injection (3 mL)

(c) Limpid solution: Akis 50 mg/mL + lidocaine 1% (1 mL) + sodium bicarbonate (3 mL)