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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 8358151, 11 pages
Research Article

Structural Modulation of Gut Microbiota during Alleviation of Suckling Piglets Diarrhoea with Herbal Formula

1College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
2Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Nature Medicine, Guangzhou, China

Correspondence should be addressed to Dayou Shi and Shining Guo

Cui Liu and Chao Zhang contributed equally to this work.

Received 23 July 2017; Revised 21 October 2017; Accepted 23 November 2017; Published 24 December 2017

Academic Editor: Francesca Mancianti

Copyright © 2017 Cui Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To determine whether the traditional Chinese herbal formula of Shen Ling Baizhu (SLB) could modulate the composition of the gut microbiota and alleviate diarrhoea in suckling piglets, twenty-four newly born piglets (Large White × Landrace × Duroc) were selected and allocated to 4 groups (control group and experimental groups I, II, and III) randomly. Faecal microbiome composition was assessed by 16S rRNA gene 454-pyrosequencing. The result indicated that experimental groups I and II exhibited significantly different gut microbiota from the control group. Most notably, the genera Lactobacillus and Bifidobacterium were significantly elevated in experimental group II compared with the control group (). Collinsella and Faecalibacterium were also enhanced in experimental group II compared with the control group (). The results showed that SLB treatment could modulate the gut microbiota composition of suckling piglets, enriching the amount of beneficial bacteria in particular. The observed changes in the gut microbiota could provide the basis for further research on the pharmacological mechanism of the tested Chinese herbal formula.