Evidence-Based Complementary and Alternative Medicine

Research Article

Synergistic Antioxidant and Anti-Inflammatory Effects between Modified Citrus Pectin and Honokiol

Table 1

Dose-effect relationship between modified citrus pectin (MCP) and honokiol (HNK).


Biochemical traits	CI at ED₅₀	CI at ED₇₅	CI at ED₉₀	DRI-MCP ED₅₀	DRI-HNK ED₅₀

Inhibition of LPS-induced TNF-	0.549	0.515	0.510	1.825	706.268
Antioxidant activity	0.670	0.546	0.446	33.682	1.562
Inhibition of lipid peroxidation	1.070	1.765	1.189	—	—
Nitric oxide synthesis (NO₂ + NO₃)	2.932	4.675	5.684	—	—
Inhibition of NFB activity	0.068	0.131	0.254	14.749	917.283
Inhibition of COX-II activity	2.248	3.080	1.870	—	—

CI, combination index; DRI, drug reduction index; ED, effective dose; CI values by CompuSyn analysis: <0.1: very strong synergism; 0.1–0.3: strong synergism; 0.3–0.7: synergism; 0.7–0.85: moderate synergism; 0.85–0.90: slight synergism; 0.90–1.10: nearly additive; 1.10–1.20: slight antagonism; 1.20–1.45: moderate antagonism; 1.45–3.3: antagonism; 3.3–10: strong antagonism; >10: very strong antagonism.