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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 8429290, 11 pages
Research Article

Passiflora cincinnata Extract Delays the Development of Motor Signs and Prevents Dopaminergic Loss in a Mice Model of Parkinson’s Disease

1Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil
2Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
3Universidade Federal de São Paulo, São Paulo, SP, Brazil
4Universidade Federal de São Paulo, Santos, SP, Brazil

Correspondence should be addressed to Alessandra Mussi Ribeiro; moc.liamg@birmela

Received 24 March 2017; Accepted 20 June 2017; Published 1 August 2017

Academic Editor: Gunhyuk Park

Copyright © 2017 Luiz Eduardo Mateus Brandão et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Passiflora cincinnata Masters is a Brazilian native species of passionflower. This genus is known in the American continent folk medicine for its diuretic and analgesic properties. Nevertheless, few studies investigated possible biological effects of P. cincinnata extracts. Further, evidence of antioxidant actions encourages the investigation of possible neuroprotective effects in animal models of neurodegenerative diseases. This study investigates the effect of the P. cincinnata ethanolic extract (PAS) on mice submitted to a progressive model of Parkinson’s disease (PD) induced by reserpine. Male (6-month-old) mice received reserpine (0.1 mg/kg, s.c.), every other day, for 40 days, with or without a concomitant treatment with daily injections of PAS (25 mg/kg, i.p.). Catalepsy, open field, oral movements, and plus-maze discriminative avoidance evaluations were performed across treatment, and immunohistochemistry for tyrosine hydroxylase was conducted at the end. The results showed that PAS treatment delayed the onset of motor impairments and prevented the occurrence of increased catalepsy behavior in the premotor phase. However, PAS administration did not modify reserpine-induced cognitive impairments. Moreover, PAS prevented the decrease in tyrosine hydroxylase immunostaining in the substantia nigra pars compacta (SNpc) induced by reserpine. Taken together, our results suggested that PAS exerted a neuroprotective effect in a progressive model of PD.