Anticancer Efficacy of Cordyceps militaris Ethanol Extract in a Xenografted Leukemia Model

Figure 1

Anticancer activity of Cm-EE in a xenograft mouse model with RMA cell-derived cancer. RMA cells (1 × 10⁶ cells per mouse) were injected subcutaneously into backs next to right hind legs. Mice with RMA cells were sorted into groups ( = 10/group) for orally administrated Cm-EE (20 mg/kg) or vehicle. (a) Tumors grown in xenograft mouse model with RMA cell-derived cancer were taken by a digital camera. (b) Induced tumor sizes were measured at indicated days until experiment end. (c) Effect of Cm-EE on proteins in apoptotic pathways was evaluated through determining the levels of total and phosphorylated Akt, p85, GSK3β, cleaved caspase-3, and β-actin in tumor tissues by immunoblotting analysis. (d) Phytochemical finger printing of Cm-EE was evaluated by HPLC analysis. and compared with control.

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