Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 8721257, 12 pages
https://doi.org/10.1155/2017/8721257
Research Article

Garidisan: Improving the Quality of Ulcer Healing in Rats with Ulcerative Colitis

1Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China
2Department of Histology and Embryology, Xinxiang Medical University, Xinxiang, Henan 453003, China
3Key Laboratory of Chinese Minority Traditional Medicine, Minzu University of China, State Ethnic Affairs Commission and Ministry of Education, Beijing 100081, China

Correspondence should be addressed to Shu-Chun Li; moc.621@cslnosaj

Received 8 February 2017; Revised 21 May 2017; Accepted 6 June 2017; Published 8 August 2017

Academic Editor: José L. Rios

Copyright © 2017 Lin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Garidisan, commonly used in Mongolia to treat ulcerative colitis (UC), contains wild poppy and Artemisia frigida Willd. Clinical evidence shows that Garidisan can effectively treat UC and that recurrence is low. Thus, we evaluated the effects of Garidisan on ulcer healing quality and the regulation of immune balance in rats with experimental UC. UC was induced by immunization with TNBS and Garidisan significantly reduced DAI, CMDI, and HS. H&E staining, SEM, and VG staining showed that Garidisan repaired damaged intestinal mucosa and significantly reduced expression of ICAM-1 and CD105 in regenerated tissues of UC rats. Collagen fibers were significantly fewer as well after treatment. Garidisan elevated EGF, VEGF, bFGF, VEGFR2, and FGFR1 of UC rats, reduced CD3+CD4+/CD3+CD8+ T cell ratios, and increased CD4+Th1/CD4+Th2 cell ratios and IFN-r/IL-4 ratios in peripheral blood of UC rats. In conclusion, Garidisan promoted tissue maturation of regenerated tissues by regulating the immune balance and improved functional maturity of regenerated tissues by reducing collagen formation, promoting maturation of new blood vessels, and increasing expression of growth factors and their receptors.