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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 8746823, 18 pages
https://doi.org/10.1155/2017/8746823
Research Article

Study of the Hypoglycemic Activity of Derivatives of Isoflavones from Cicer arietinum L.

Ying Wei,1,2,3 Pengshou Li,1,2,3 Bo Li,1,2,3 Jiaqi Gao,1,2,3 Dongchao Wang,1,2,3 Lingling Qin,2,3 Wen Sun,2,3 Yunling Xu,1,2,3 Haoxia Shi,1,2,3 Tunhai Xu,1,2,3 and Tonghua Liu2,3

1School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, China
2Health Cultivation Key Laboratory of the Ministry of Education, Beijing University of Chinese Medicine, Beijing, China
3Health Cultivation Key Laboratory of Beijing, Beijing University of Chinese Medicine, Beijing, China

Correspondence should be addressed to Tunhai Xu; moc.361@uxht

Received 19 October 2016; Revised 16 January 2017; Accepted 2 February 2017; Published 21 March 2017

Academic Editor: Youn C. Kim

Copyright © 2017 Ying Wei et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The chickpea, a food and medicine used by the people of Xinjiang, has a beneficial hypoglycemic effect. To better utilize this national resource and develop hypoglycemic agents from components of the chickpea, a series of new derivatives of isoflavone compounds from the chickpea were synthesized. An insulin-resistant (IR) HepG2 cell model was used to screen the hypoglycemic activities of these compounds. And the structure-activity relationships of these compounds were explored. Additionally, several combinations of these compound displayed higher hypoglycemic activity than any single compound, and they had similar hypoglycemic activity to that of the positive control group (). In addition, combination 3 and combination 6 exerted different effects on the insulin sensitivity of H4IIE cells stimulated with resistin. And the results indicated that combination 3 would have higher hypoglycemic activity. These findings demonstrate the characteristics of multiple components and targets of Chinese herbal medicine. This evidence may provide new ideas for the development of hypoglycemic drugs.