Evaluation of Analgesic Activity of Papaver libanoticum Extract in Mice: Involvement of Opioids Receptors

Table 5

Effect of naloxone on analgesic activity of PLE using hot plate method in mice.

Treatment	Reaction time (sec, mean ± SEM)
	0 hrs	0.5 hrs	1 hr	1.5 hrs	2 hrs	3 hrs	4 hrs	6 hrs
Control (vehicle)	8.7	9.12	9.38	9.94	9.14	9.46	9.92	10.22
Naloxone (4 mg/kg)	8.56 ± 0.92	9.52 ± 0.98	9.76 ± 1.16	9.50 ± 0.86	9.44 ± 0.71	9.46 ± 0.63	9.96 ± 0.74	10.56 ± 0.36
Morphine 5 mg/kg	9 ± 0.77	23.33 ± 1.89	23.5 ± 4.45	21.67 ± 2.95	19.27 ± 2.28	18.02 ± 1.23	14.25 ± 0.93	13.67 ± 1.32
PLE 100 mg/kg	9.68 ± 0.92	14.15 ± 1.09	15.30 ± 2.99	17.62 ± 4.43	19.33 ± 2.56	20.7 ± 2.58	17.88 ± 2.34	14.57 ± 1.5
Naloxone + morphine	7.86 ± 0.74	8.92 ± 0.53	8.72 ± 0.25	8.72 ± 1.28	8.42 ± 1.43	8.78 ± 1.57	8.48 ± 0.85	8.70 ± 0.93
Naloxone + PLE	7.63 ± 0.68	7.77 ± 0.74	9.57 ± 2.08	9.52 ± 1.59	9.68 ± 1.38	9.62 ± 0.98	9.22 ± 1.02	9.38 ± 1.36

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