Herbal Medicine for the Treatment of Obesity: An Overview of Scientific Evidence from 2007 to 2017

Figure 2

Potential mechanisms of herbal medicine for obesity. Herbal medicine such as Celastrol, its main mechanism of weight reduction is inhibiting endoplasmic reticulum (ER) stress and increased leptin sensitivity. Ganoderma lucidum mycelium decreased proinflammatory cytokine expression in the liver and adipose tissues in a dose-dependent manner; Acetylshikonin covers the treatment of obesity which involves the regulation of lipid metabolism and anti-inflammatory effects and decreased serum free fatty acid. Radix Astragali reduces body weight and food intake, and alleviates glucose intolerance/insulin resistance. SNS: sympathetic nervous system; FA: fatty acid.