Evidence-Based Complementary and Alternative Medicine / 2017 / Article / Tab 1

Review Article

Chinese Classical Formula Sijunzi Decoction and Chronic Atrophic Gastritis: Evidence for Treatment Approach?

Table 1

Characteristics of the included studies.

Study IDSample size ()Diagnosis criteriaInterventionControlCourse of treatmentOutcome assessment

Song et al., 2009 [30]68 (34/34)CRGNDTCM
(including gastroscopy and pathology diagnosis)
Modified SJZD + controlMetronidazole (200 mg, twice a day), 1 week, and folate (10 mg, three times a day), 24 weeks24 weeksOverall effect rate

Hu, 2011 [31]96 (48/48)CRGNDTCM
(including gastroscopy and pathology diagnosis)
Modified SJZDDomperidone (10 mg, three times a day), colloidal bismuth pectin (200 mg, four times a day), and omeprazole (20 mg, twice a day)4 weeksOverall effect rate
Hp clearance rate

Sun et al., 2012 [32]70 (36/34)CRGNDTCM (including gastroscopy and pathology diagnosis)Modified SJZD + controlOmeprazole (30 mg, once a day) and colloidal bismuth pectin (120 mg, three times a day)
Abdominal distension or regurgitation onset: domperidone (10 mg, three times a day)
HP infection: amoxicillin (500 mg, three times a day) and tinidazole (1 g, three times a day)
3 weeksOverall effect rate

Li, 2013 [33]126 (63/63)Not reportedModified SJZD + controlBismuth potassium citrate (300 mg, three or four times a day)Not reportedOverall effect rate

Zhang, 2016 [34]64 (32/32)Gastroscopy diagnosis: DCBDACMA
Pathology diagnosis:
SNCMCG
Modified SJZD + controlOmeprazole (20 mg, twice a day), clarithromycin (0.5 g, once a day), amoxicillin (1 g, twice a day), 14 days; and folate (10 mg, three times a day), 12 weeks12 weeksHistologic grading score

Shen, 2016 [35]78 (39/39)Not reported, but mentioned pathological examination with the help of gastroscopyModified SJZD + controlMetronidazole (400 mg, twice a day), Lansoprazole (30 mg, twice a day), and Levofloxacin (200 mg, twice a day)12 weeksOverall effect rate

: treatment group; : control group; CRGNDTCM: clinical research guideline on new drugs of traditional Chinese medicine; DCBDACMA: diagnosis criterion of Chinese digestive endoscopy association; SNCMCG: second national consensus meeting on chronic gastritis in China; SJZD: Sijunzi decoction.

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