Chinese Classical Formula Sijunzi Decoction and Chronic Atrophic Gastritis: Evidence for Treatment Approach?

Table 1

Characteristics of the included studies.

Study ID	Sample size ()	Diagnosis criteria	Intervention	Control	Course of treatment	Outcome assessment
Song et al., 2009 [30]	68 (34/34)	CRGNDTCM; (including gastroscopy and pathology diagnosis)	Modified SJZD + control	Metronidazole (200 mg, twice a day), 1 week, and folate (10 mg, three times a day), 24 weeks	24 weeks	Overall effect rate
Hu, 2011 [31]	96 (48/48)	CRGNDTCM; (including gastroscopy and pathology diagnosis)	Modified SJZD	Domperidone (10 mg, three times a day), colloidal bismuth pectin (200 mg, four times a day), and omeprazole (20 mg, twice a day)	4 weeks	Overall effect rate; Hp clearance rate
Sun et al., 2012 [32]	70 (36/34)	CRGNDTCM (including gastroscopy and pathology diagnosis)	Modified SJZD + control	Omeprazole (30 mg, once a day) and colloidal bismuth pectin (120 mg, three times a day); Abdominal distension or regurgitation onset: domperidone (10 mg, three times a day); HP infection: amoxicillin (500 mg, three times a day) and tinidazole (1 g, three times a day)	3 weeks	Overall effect rate
Li, 2013 [33]	126 (63/63)	Not reported	Modified SJZD + control	Bismuth potassium citrate (300 mg, three or four times a day)	Not reported	Overall effect rate
Zhang, 2016 [34]	64 (32/32)	Gastroscopy diagnosis: DCBDACMA; Pathology diagnosis: SNCMCG	Modified SJZD + control	Omeprazole (20 mg, twice a day), clarithromycin (0.5 g, once a day), amoxicillin (1 g, twice a day), 14 days; and folate (10 mg, three times a day), 12 weeks	12 weeks	Histologic grading score
Shen, 2016 [35]	78 (39/39)	Not reported, but mentioned pathological examination with the help of gastroscopy	Modified SJZD + control	Metronidazole (400 mg, twice a day), Lansoprazole (30 mg, twice a day), and Levofloxacin (200 mg, twice a day)	12 weeks	Overall effect rate

: treatment group; : control group; CRGNDTCM: clinical research guideline on new drugs of traditional Chinese medicine; DCBDACMA: diagnosis criterion of Chinese digestive endoscopy association; SNCMCG: second national consensus meeting on chronic gastritis in China; SJZD: Sijunzi decoction.