Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS

Table 4

Recoveries and matrix effects of eleven compounds ().

Compounds	Concentration (ngmL^−1)	Recovery		Matrix effect
		Mean (%)	RSD (%)	Mean (%)	RSD (%)
Paeoniflorin	7.5	100	7.8	152	12
	75	96.6	12	127	11
	750	83.6	12	146	12
Ecdysterone	15	98.9	6.2	80.0	12
	150	83.6	9.6	95.8	11
	1500	104	7.0	110	13
Amygdalin	30	107	12	78.0	4.8
	300	90.5	7.8	82.6	7.8
	3000	87.2	13	75.7	11
Mulberroside A	30	78.7	4.9	84.3	5.6
	300	92.0	15	76.0	14
	3000	76.6	5.9	73.7	8.2
Caffeic acid	30	98.2	7.1	96.4	3.6
	300	81.8	12	107	9.9
	3000	88.7	6.3	109	7.5
Ferulic acid	15	91.6	6.5	101	3.7
	150	79.6	6.8	89.5	4.4
	1500	93.2	7.5	92.6	8.9
Salvianolic acid B	30	82.6	14	105	11
	300	62.7	10	82.7	6.2
	3000	81.2	8.5	76.0	9.7
Astragaloside IV	30	91.0	9.0	109	9.3
	300	95.2	4.7	109	14
	3000	97.1	13	115	3.0
Formononetin	0.75	87.9	7.5	98.5	4.2
	7.5	103	12	87.7	9.3
	75	99.7	13	106	13
Cryptotanshinone	3	97.0	14	75.3	12
	30	76.2	8.2	89.0	4.6
	300	76.0	14	79.0	5.5
Tanshinone IIA	0.75	99.6	9.3	92.0	5.2
	7.5	60.0	14	96.0	8.4
	75	81.5	6.6	90.0	11