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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 9187167, 13 pages
Research Article

Antiobesity and Anti-Inflammatory Effects of Orally Administered Bonito Extracts on Mice Fed a High-Fat Diet

Department of Microbiology, Faculty of Medicine, Oita University, Yufu, Oita 879-5593, Japan

Correspondence should be addressed to Hidekatsu Iha;

Received 16 April 2017; Accepted 5 July 2017; Published 24 October 2017

Academic Editor: Norman Temple

Copyright © 2017 Emi Ikebe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. The condensed fermentative extract of bonito (BoE), skipjack tuna (Katsuwonus pelamis), has claimed its health conditioning effects against lifestyle-related diseases such as hypertension and type 2 diabetes. Methods. We evaluated the antiobesity and anti-inflammatory effects of BoE on mice fed a high-fat diet (HFD). Mice (9 weeks of age) were maintained for 11 weeks on HFD with or without BoE (50 mg or 500 mg/kg). Results. Compared with untreated mice, BoE50 or BoE500 mice achieved maximum weight reductions of 7.4% (males) and 11.4% (females), and visceral fat in male BoE500 mice was more decreased among all mice ( = 0.00459). Furthermore, an antiobesity gene uncoupling protein-1 was significantly induced in the visceral fat tissues of male BoE500 ( = 0.0110) and female BoE50 and BoE500 mice ( = 0.0110 and = 0.0110, resp.). Finally, we detected reduced amount of granulocyte-colony stimulating factor ( = 0.0250) in the sera of female BoE50 and interleukin- (IL-) 5 ( = 0.0120), IL-6 ( = 0.0118), and IL-13 ( = 0.0243) in female BoE500 mice. Conclusion. The antiobesity and anti-inflammatory effects of BoE were demonstrated with our examination system and any toxic adverse effects were not observed in mice during the 3-month investigation.