Extracts of Salvia-Nelumbinis Naturalis Ameliorate Nonalcoholic Steatohepatitis via Inhibiting Gut-Derived Endotoxin Mediated TLR4/NF-κB Activation

Figure 4

The effect of SNN extracts on liver inflammation. Male C57Bl/6 mice (7 weeks of age) were fed HF-DSS diet for 12 weeks followed by either 4-week SNN () or normal saline supplementation via gavage (), while chow diet mice were set as controls (Con, ). The mice were sacrificed, liver tissues were collected and stained with HE (a), and Kupffer cell activation was indicated by the F4/80 IHC (b). Image magnification ×200. Hepatic IL-6 (c), MCP-1 (d), and TNFα (e) mRNA was qualified by qRT-PCR. Data were present as mean ± SE, , , and versus Con mice; ^▲ versus HF-DSS (NASH) mice.

(a)

(b)

(c)

(d)

(e)