Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor

Figure 1

Inhibition of PAI-1 activity by fractions of the Resina Draconis extract and identification of the main PAI-1-inhibiting component. (a) Preparative HPLC chromatogram of the ethanol extract of Resina Draconis. (b) PAI-1 inhibitory activity assay of fractions 28 to 40 of Resina Draconis extract obtained from preparative HPLC. (c) Resolution of fraction 34 of Resina Draconis extract by analytical HPLC. Analytical HPLC chromatogram of P2 of fraction 34 from B (d) and loureirin B standard (e) obtained under the same chromatographic condition. Inset: chemical structure of LB.

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