Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Polygonum multiflorum Related to the Activity Inhibition of CYP1A2 or CYP2E1

Figure 4

The measurements of transaminases levels at 1 d, 3 d, 5 d, 7 d, 22 d, 44 d, and 46 d after prolonged and repeated oral administration of PMR: oral administration of PMR to rats for 1–7 d, 1 d after 2 w stop (interval), 1–3 d for 3 w stop, and 37 d for transaminases level during oral administration interval . (a) and (b) for ALT level. (c) and (d) for AST level. difference compared with other groups, . significant difference compared with other groups, .

(a)

(b)

(c)

(d)