Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 9536458, 8 pages
https://doi.org/10.1155/2017/9536458
Research Article

Dahuang Fuzi Decoction Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in Chronic Aristolochic Acid Nephropathy

1The First Affiliated Hospital of First Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing 210029, China
2Department of Nephrology, Changshu No. 2 People’s Hospital, Changshu 215500, China
3Department of Second Clinical Medical School, Nanjing University of Chinese Medicine, Nanjing 210029, China

Correspondence should be addressed to Wei Sun; moc.361@iewnussj

Received 31 December 2016; Accepted 27 February 2017; Published 21 March 2017

Academic Editor: Jairo Kennup Bastos

Copyright © 2017 Guang-xing Shui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. D. Debelle, J.-L. Vanherweghem, and J. L. Nortier, “Aristolochic acid nephropathy: a worldwide problem,” Kidney International, vol. 74, no. 2, pp. 158–169, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. F. D. Debelle, J. L. Nortier, E. G. De Prez et al., “Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats,” Journal of the American Society of Nephrology, vol. 13, no. 2, pp. 431–436, 2002. View at Google Scholar · View at Scopus
  3. C. Zhu, S. Huang, Y. Yuan et al., “Mitochondrial dysfunction mediates aldosterone-induced podocyte damage: a therapeutic target of PPARγ,” American Journal of Pathology, vol. 178, no. 5, pp. 2020–2031, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Hagiwara, K. Yamagata, R. A. Capaldi, and A. Koyama, “Mitochondrial dysfunction in focal segmental glomerulosclerosis of puromycin aminonucleoside nephrosis,” Kidney International, vol. 69, no. 7, pp. 1146–1152, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Yuan, S. Huang, W. Wang et al., “Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury,” Kidney International, vol. 82, no. 7, pp. 771–789, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Tu, W. Sun, Y.-G. Wan et al., “Dahuang Fuzi Decoction ameliorates tubular epithelial apoptosis and renal damage via inhibiting TGF-β1-JNK signaling pathway activation in vivo,” Journal of Ethnopharmacology, vol. 156, pp. 115–124, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Li, H. Guo, L. Wu et al., “Comparative pharmacokinetics study of three anthraquinones in rat plasma after oral administration of Radix et Rhei Rhizoma extract and Dahuang Fuzi Tang by high performance liquid chromatography-mass spectrometry,” Journal of Pharmaceutical and Biomedical Analysis, vol. 76, pp. 215–218, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Huang, A. Zhang, G. Ding, and R. Chen, “Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation,” American Journal of Physiology—Renal Physiology, vol. 296, no. 6, pp. F1323–F1333, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. J.-L. Vanherweghem, “Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy),” The Journal of Alternative and Complementary Medicine, vol. 4, no. 1, pp. 9–13, 1998. View at Publisher · View at Google Scholar · View at Scopus
  10. S. H.-K. Lo, K.-L. Mo, K.-S. Wong et al., “Aristolohic acid nephropathy complicating a patient with focal segmental glomerulosclerosis,” Nephrology Dialysis Transplantation, vol. 19, no. 7, pp. 1913–1915, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Yang, X. Li, and H. Wang, “Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid-induced acute tubular necrosis,” Nephrology Dialysis Transplantation, vol. 22, no. 2, pp. 445–456, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. Y.-Y. Zhao, H.-L. Wang, X.-L. Cheng et al., “Metabolomics analysis reveals the association between lipid abnormalities and oxidative stress, inflammation, fibrosis, and Nrf2 dysfunction in aristolochic acid-induced nephropathy,” Scientific Reports, vol. 5, Article ID 12936, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. T.-B. Zhou, Y.-H. Qin, F.-Y. Lei, W.-F. Huang, and G. P. C. Drummen, “Prohibitin attenuates oxidative stress and extracellular matrix accumulation in renal interstitial fibrosis disease,” PLoS ONE, vol. 8, no. 10, Article ID e77187, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. Y.-X. Zhou, W. Xia, W. Yue, C. Peng, K. Rahman, and H. Zhang, “Rhein: a review of pharmacological activities,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, Article ID 578107, 10 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Yang, Z. Zeng, T. Wu, Z. Yang, B. Liu, and T. Lan, “Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway,” Experimental Cell Research, vol. 319, no. 20, pp. 3182–3189, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. B. Arosio, N. Gagliano, L. M. P. Fusaro et al., “Aloe-emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride,” Pharmacology and Toxicology, vol. 87, no. 5, pp. 229–233, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Zhu, X. Xuan, R. Che et al., “Dysfunction of the PGC-1α-mitochondria axis confers adriamycin-induced podocyte injury,” American Journal of Physiology—Renal Physiology, vol. 306, no. 12, pp. F1410–F1417, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. R. Che, C. Zhu, G. Ding et al., “Huaier cream protects against adriamycin-induced nephropathy by restoring mitochondrial function via PGC-1α upregulation,” PPAR Research, vol. 2015, Article ID 720383, 11 pages, 2015. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Che, Y. Yuan, S. Huang, and A. Zhang, “Mitochondrial dysfunction in the pathophysiology of renal diseases,” American Journal of Physiology—Renal Physiology, vol. 306, no. 4, pp. F367–F378, 2014. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Granata, A. Dalla Gassa, P. Tomei, A. Lupo, and G. Zaza, “Mitochondria: a new therapeutic target in chronic kidney disease,” Nutrition & Metabolism, vol. 12, article 49, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. A. M. James and M. P. Murphy, “How mitochondrial damage affects cell function,” Journal of Biomedical Science, vol. 9, no. 6, part 1, pp. 475–487, 2002. View at Publisher · View at Google Scholar · View at Scopus