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Evidence-Based Complementary and Alternative Medicine
Volume 2017 (2017), Article ID 9596256, 13 pages
https://doi.org/10.1155/2017/9596256
Research Article

Aristolochic Acid-Induced Autophagy Promotes Epithelial-to-Myofibroblast Transition in Human Renal Proximal Tubule Epithelial Cells

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China

Correspondence should be addressed to Yi-Pu Chen; nc.moc.liamdem@upiy_nehc

Received 29 April 2017; Revised 10 August 2017; Accepted 5 September 2017; Published 18 October 2017

Academic Editor: Cheorl-Ho Kim

Copyright © 2017 Yu-Lin Man et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. R. Gökmen, J. Cosyns, V. M. Arlt et al., “The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review,” Annals of Internal Medicine, vol. 158, no. 6, pp. 469–477, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. I. Jadot, A.-E. Declèves, J. Nortier, and N. Caron, “An integrated view of aristolochic acid nephropathy: Update of the literature,” International Journal of Molecular Sciences, vol. 18, no. 2, article no. 297, 2017. View at Publisher · View at Google Scholar · View at Scopus
  3. A. P. Grollman, “Aristolochic acid nephropathy: Harbinger of a global iatrogenic disease,” Environmental and Molecular Mutagenesis, vol. 54, no. 1, pp. 1–7, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. H.-L. Rui, Y.-Y. Wang, H. Cheng, and Y.-P. Chen, “JNK-dependent AP-1 activation is required for aristolochic acid-induced TGF-β1 synthesis in human renal proximal epithelial cells,” American Journal of Physiology-Renal Physiology, vol. 302, no. 12, pp. F1569–F1575, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. X.-Y. Xu, J.-J. Chai, Y.-P. Chen et al., “Hirsutella sinensis attenuates aristolochic acid-induced renal tubular epithelial mesenchymal transition by inhibiting TGF-β1 and snail expression,” PLoS ONE, vol. 11, no. 2, Article ID e0149242, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Bai, H. Lu, L. Hu, D. Hong, L. Ding, and B. Chen, “Effect of Sedum sarmentosum BUNGE extract on aristolochic acid-induced renal tubular epithelial cell injury,” Journal of Pharmacological Sciences, vol. 124, no. 4, pp. 445–456, 2014. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Yang and Y. Liu, “Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis,” The American Journal of Pathology, vol. 159, no. 4, pp. 1465–1475, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. D. Zhou and Y. Liu, “Renal fibrosis in 2015: understanding the mechanisms of kidney fibrosis,” Nature Reviews Nephrology, vol. 12, no. 2, pp. 68–70, 2016. View at Publisher · View at Google Scholar · View at Scopus
  9. B. Sutariya, D. Jhonsa, and M. N. Saraf, “TGF-β: the connecting link between nephropathy and fibrosis,” Immunopharmacology and Immunotoxicology, vol. 38, no. 1, pp. 39–49, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Bedi, A. Vidyasagar, and A. Djamali, “Epithelial-to-mesenchymal transition and chronic allograft tubulointerstitial fibrosis,” Transplantation Reviews, vol. 22, no. 1, pp. 1–5, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. M. T. Grande, B. Sánchez-Laorden, C. López-Blau et al., “Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease,” Nature Medicine, vol. 21, no. 9, pp. 989–997, 2015. View at Publisher · View at Google Scholar
  12. Y. Li, Z. Wang, S. Wang, J. Zhao, J. Zhang, and Y. Huang, “Gremlin-mediated decrease in bone morphogenetic protein signaling promotes aristolochic acid-induced epithelial-to-mesenchymal transition (EMT) in HK-2 cells,” Toxicology, vol. 297, no. 1-3, pp. 68–75, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Takabatake, T. Kimura, A. Takahashi, and Y. Isaka, “Autophagy and the kidney: Health and disease,” Nephrology Dialysis Transplantation , vol. 29, no. 9, pp. 1639–1647, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. L. E. Gallagher and E. Y. W. Chan, “Early signalling events of autophagy,” Essays in Biochemistry, vol. 55, no. 1, pp. 1–15, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. T. B. Huber, C. L. Edelstein, B. Hartleben et al., “Emerging role of autophagy in kidney function, diseases and aging,” Autophagy, vol. 8, no. 7, pp. 1009–1031, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. O. Yamaguchi, M. Taneike, and K. Otsu, “Cooperation between proteolytic systems in cardiomyocyte recycling,” Cardiovascular Research, vol. 96, no. 1, pp. 46–52, 2012. View at Publisher · View at Google Scholar · View at Scopus
  17. F. Lin, Autophagy in renal tubular injury and repair, Acta physiologica, Oxford, England, 2017.
  18. S. Sahni, A. M. Merlot, S. Krishan, P. J. Jansson, and D. R. Richardson, “Gene of the month: BECN1,” Journal of Clinical Pathology, vol. 67, pp. 656–660, 2014. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Zeng, X. Yang, J. Wang, J. Fan, Q. Kong, and X. Yu, “Aristolochic acid I induced autophagy extenuates cell apoptosis via ERK 1/2 pathway in renal tubular epithelial cells,” PLoS ONE, vol. 7, no. 1, Article ID e30312, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. C.-C. Yang, C.-T. Wu, L.-P. Chen, K.-Y. Hung, S.-H. Liu, and C.-K. Chiang, “Autophagy induction promotes aristolochic acid-I-induced renal injury in vivo and in vitro,” Toxicology, vol. 312, no. 1, pp. 63–73, 2013. View at Publisher · View at Google Scholar · View at Scopus
  21. V. S. Lebleu, G. Taduri, J. O'Connell et al., “Origin and function of myofibroblasts in kidney fibrosis,” Nature Medicine, vol. 19, no. 8, pp. 1047–1053, 2013. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Iwano, D. Plieth, T. M. Danoff, C. Xue, H. Okada, and E. G. Neilson, “Evidence that fibroblasts derive from epithelium during tissue fibrosis,” The Journal of Clinical Investigation, vol. 110, no. 3, pp. 341–350, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. T. M. Ballhause, R. Soldati, and P. R. Mertens, “Sources of myofibroblasts in kidney fibrosis: all answers are correct, however to different extent!,” International Urology and Nephrology, vol. 46, no. 3, pp. 659–664, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. A. A. Pozdzik, I. J. Salmon, F. D. Debelle et al., “Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation,” Kidney International, vol. 73, no. 5, pp. 595–607, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. C. H. Jung, S. H. Ro, J. Cao, N. M. Otto, and D. H. Kim, “mTOR regulation of autophagy,” FEBS Letters, vol. 584, no. 7, pp. 1287–1295, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. C. Puente, R. C. Hendrickson, and X. Jiang, “Nutrient-regulated phosphorylation of ATG13 inhibits starvation-induced autophagy,” The Journal of Biological Chemistry, vol. 291, no. 11, pp. 6026–6035, 2016. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Du, R.-J. Teng, T. Guan et al., “Role of autophagy in angiogenesis in aortic endothelial cells,” American Journal of Physiology-Cell Physiology, vol. 302, no. 2, pp. C383–C391, 2012. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Pang, H. Wang, and P. Rao, “Autophagy links β-catenin and Smad signaling to promote epithelial-mesenchymal transition via upregulation of integrin linked kinase,” in Proceedings of the The international journal of biochemistry cell biology, vol. 76, pp. 123–134, 2016.
  29. S. Y. Moon, H. S. Kim, K. W. Nho, Y. J. Jang, and S. K. Lee, “Endoplasmic reticulum stress induces epithelial-mesenchymal transition through autophagy via activation of c-src kinase,” Nephron Experimental Nephrology, vol. 126, no. 3, pp. 127–140, 2014. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Xu, L. Liu, W. Xin et al., “The renoprotective role of autophagy activation in proximal tubular epithelial cells in diabetic nephropathy,” Journal of Diabetes and its Complications, vol. 29, no. 8, pp. 976–983, 2015. View at Publisher · View at Google Scholar · View at Scopus
  31. S. Sridhar, Y. Botbol, F. MacIan, and A. M. Cuervo, “Autophagy and disease: Always two sides to a problem,” The Journal of Pathology, vol. 226, no. 2, pp. 255–273, 2012. View at Publisher · View at Google Scholar · View at Scopus