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Evidence-Based Complementary and Alternative Medicine
Volume 2017, Article ID 9814836, 11 pages
Research Article

Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice

1Center for Metabolic Function Regulation and Department of Microbiology, School of Medicine, Wonkwang University, Iksan 54538, Republic of Korea
2Zoonosis Research Center, School of Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
3Jeongwoo Pharmaceutical Co., Ltd., Asan, Chungnam 336885, Republic of Korea
4Professional Graduate School of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
5Integrated Omics Institute, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
6Department of Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
7Institute of Pharmaceutical Research and Development, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea

Correspondence should be addressed to Kyung Song;

Received 20 May 2017; Revised 13 August 2017; Accepted 28 September 2017; Published 15 November 2017

Academic Editor: Claudia Di Giacomo

Copyright © 2017 Min Soo Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Noise-induced hearing loss (NIHL) results from the damage of the delicate hair cells inside the ear after excessive stimulation of noise. Unlike certain lower animals such as amphibians, fishes, and birds, in humans, hair cells cannot be regenerated once they are killed or damaged; thus, there are no therapeutic options to cure NIHL. Therefore, it is more important to protect hair cells from the noise before the damage occurs. In this study, we report the protective effect of Yang Mi Ryung extract (YMRE) against NIHL; this novel therapeutic property of YMRE has not been reported previously. Our data demonstrates that the hearing ability damaged by noise is markedly restored in mice preadministrated with YMRE before noise exposure, to the level of normal control group. Our study also provides the molecular mechanism underlying the protective effect of YMRE against NIHL by showing that YMRE significantly blocks noise-induced apoptotic cell death and reduces reactive oxygen species (ROS) production in cochleae. Moreover, quantitative polymerase chain reaction (qPCR) analysis demonstrates that YMRE has anti-inflammatory properties, suppressing the mRNA levels of TNFα and IL-1β induced by noise exposure. In conclusion, YMRE could be a useful preventive intervention to prevent hearing impairment induced by the exposure to excessive noise.