Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 1098015, 8 pages
https://doi.org/10.1155/2018/1098015
Research Article

Lupinus mutabilis Edible Beans Protect against Bacterial Infection in Uroepithelial Cells

1Department of Microbiology, Tumor and Cell Biology, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden
2Department of Molecular Medicine and Surgery, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden
3Area de Farmacologia, Instituto de Investigaciones Farmaco Bioquimicas, Facultad de Ciencias Farmacéuticas y Bioquimicas, Universidad Mayor de San Andres, La Paz, Bolivia

Correspondence should be addressed to Annelie Brauner; es.ik@renuarb.eilenna

Received 29 July 2018; Revised 6 November 2018; Accepted 15 November 2018; Published 16 December 2018

Guest Editor: Constantinos Athanassopoulos

Copyright © 2018 Witchuda Kamolvit et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. Foxman, “The epidemiology of urinary tract infection,” Nature Reviews Urology, vol. 7, no. 12, pp. 653–660, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. V. de Lastours and B. Foxman, “Urinary tract infection in diabetes: epidemiologic considerations,” Current Infectious Disease Reports, vol. 16, no. 1, article 389, 2014. View at Publisher · View at Google Scholar · View at Scopus
  3. A. Brauner, U. Flodin, B. Hylander, and C. G. Östenson, “Bacteriuria, Bacterial Virulence and Host Factors in Diabetic Patients,” Diabetic Medicine, vol. 10, no. 6, pp. 550–554, 1993. View at Publisher · View at Google Scholar · View at Scopus
  4. H. Brauner, P. Lüthje, J. Grünler et al., “Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity,” Clinical & Experimental Immunology, vol. 177, no. 2, pp. 478–482, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. T. E. Eichler, B. Becknell, R. S. Easterling et al., “Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract,” Kidney International, vol. 90, no. 3, pp. 568–579, 2016. View at Publisher · View at Google Scholar · View at Scopus
  6. D. S. Eto, T. A. Jones, J. L. Sundsbak, and M. A. Mulvey, “Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli,” PLoS Pathogens, vol. 3, no. 7, pp. 0949–0961, 2007. View at Google Scholar · View at Scopus
  7. M. Zasloff, “Antimicrobial peptides of multicellular organisms,” Nature, vol. 415, no. 6870, pp. 389–395, 2002. View at Publisher · View at Google Scholar · View at Scopus
  8. O. Hertting, Å. Holm, P. Lüthje et al., “Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder,” PLoS ONE, vol. 5, no. 12, Article ID e15580, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Lüthje, E. F. Lokman, C. Sandström, C.-G. Östenson, and A. Brauner, “Gynostemma pentaphyllum exhibits anti-inflammatory properties and modulates antimicrobial peptide expression in the urinary bladder,” Journal of Functional Foods, vol. 17, pp. 283–292, 2015. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Mohanty, W. Kamolvit, S. Zambrana et al., “Extract of Clinopodium bolivianum protects against E. coli invasion of uroepithelial cells,” Journal of Ethnopharmacology, vol. 198, pp. 214–220, 2017. View at Publisher · View at Google Scholar · View at Scopus
  11. F. E. Carvajal-Larenas, A. R. Linnemann, M. J. R. Nout, M. Koziol, and M. A. J. S. van Boekel, “Lupinus mutabilis: Composition, Uses, Toxicology, and Debittering,” Critical Reviews in Food Science and Nutrition, vol. 56, no. 9, pp. 1454–1487, 2016. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Fornasini, J. Castro, E. Villacres, L. Narvaez, M. P. Villamar, and M. E. Baldeon, “Hypoglycemic effect of lupinus mutabilis in healthy volunteers and subjects with dysglycemia,” Nutrición Hospitalaria, vol. 27, no. 2, pp. 425–433, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Wiedemann, C. M. Gurrola-Díaz, B. Vargas-Guerrero, M. Wink, P. M. García-López, and M. Düfer, “Lupanine improves glucose homeostasis by influencing KATP channels and insulin gene expression,” Molecules, vol. 20, no. 10, pp. 19085–19100, 2015. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Kai-Larsen, P. Lüthje, M. Chromek et al., “Uropathogenic Escherichia coli Modulates Immune Responses and Its Curli Fimbriae Interact with the Antimicrobial Peptide LL-37,” PLoS Pathogens, vol. 6, no. 7, p. e1001010, 2010. View at Publisher · View at Google Scholar
  15. P. Luthje, H. Brauner, N. L. Ramos et al., “Estrogen supports urothelial defense mechanisms,” Science Translational Medicine, vol. 5, no. 190, pp. 190ra80–190ra80, 2013. View at Publisher · View at Google Scholar
  16. G. R. Nielubowicz and H. L. T. Mobley, “Host-pathogen interactions in urinary tract infection,” Nature Reviews Urology, vol. 7, no. 8, pp. 430–441, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Mohanty, S. Zambrana, S. Dieulouard et al., “Amaranthus caudatus extract inhibits the invasion of E. coli into uroepithelial cells,” Journal of Ethnopharmacology, vol. 220, pp. 155–158, 2018. View at Publisher · View at Google Scholar
  18. G. Zhou, W.-J. Mo, P. Sebbel et al., “Uroplakin la is the urothelial receptor for uropathogenic: Escherichia coli: Evidence from in vitro FimH binding,” Journal of Cell Science, vol. 114, no. 22, pp. 4095–4103, 2001. View at Google Scholar · View at Scopus
  19. S. Langermann, R. Möllby, J. E. Burlein et al., “Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli,” The Journal of Infectious Diseases, vol. 181, no. 2, pp. 774–778, 2000. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Jarvis, Z. Han, V. Kalas et al., “Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI,” ChemMedChem, vol. 11, no. 4, pp. 367–373, 2016. View at Publisher · View at Google Scholar · View at Scopus
  21. B. Kranjčec, D. Papeš, and S. Altarac, “D-mannose powder for prophylaxis of recurrent urinary tract infections in women: A randomized clinical trial,” World Journal of Urology, vol. 32, no. 1, pp. 79–84, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Chromek and A. Brauner, “Antimicrobial mechanisms of the urinary tract,” Journal of Molecular Medicine, vol. 86, no. 1, pp. 37–47, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. Z.-J. Shao, X.-W. Zheng, T. Feng et al., “Andrographolide exerted its antimicrobial effects by upregulation of human β-defensin-2 induced through p38 MAPK and NF-kB pathway in human lung epithelial cells,” Canadian Journal of Physiology and Pharmacology, vol. 90, no. 5, pp. 647–653, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. B. W. Hayes and S. N. Abraham, “Innate Immune Responses to Bladder Infection,” Microbiology Spectrum, vol. 4, no. 6, 2016. View at Publisher · View at Google Scholar
  25. J. Lehmann, M. Retz, J. Harder et al., “Expression of human beta-defensins 1 and 2 in kidneys with chronic bacterial infection,” BMC Infectious Diseases, vol. 2, article 20, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. J. D. Spencer, A. L. Schwaderer, H. Wang et al., “Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract,” Kidney International, vol. 83, no. 4, pp. 615–625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Zambrana, L. Lundqvist, O. Mamani, S. Catrina, E. Gonzales, and C. Östenson, “Lupinus mutabilis Extract Exerts an Anti-Diabetic Effect by Improving Insulin Release in Type 2 Diabetic Goto-Kakizaki Rats,” Nutrients, vol. 10, no. 7, p. 933, 2018. View at Publisher · View at Google Scholar