Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model

Figure 1

The effect of SB on pulmonary function in CS-exposed rats of different stages. Rats were exposed to CS for 12 weeks, 24 weeks, and 36 weeks with SB (1.5, 3, and 6 mg/(kg⋅d)) or BUD (0.2 mg/(kg⋅d)). Pulmonary function: FEV0.1/FVC (%) (a), PEF (b), MMEF (c), and FRC (d) were measured which indicated the model of COPD was successfully established. Data are mean ± SEM . , , compared with the normal control group. , , compared with the COPD model group. , , compared with BUD group. CS = cigarette smoking; SB = Scutellaria baicalensis; BUD = Budesonide; FEV0.1 = forced expiratory volume in the first 0.1 seconds; FVC = forced vital capacity; PEF = forced expiratory flow; MMEF = maximum mid expiratory flow rate; and FRC = functional residual capacity.

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