Scutellaria baicalensis Attenuates Airway Remodeling via PI3K/Akt/NF-κB Pathway in Cigarette Smoke Mediated-COPD Rats Model

Figure 7

The effect of SB on cytokines, TGF-β1, MMP-2, MMP-9, and TIMP-1. Rats were exposed to CS for 12, 24, and 36 weeks with SB (1.5, 3, and 6 mg/(kg⋅d)) or BUD (0.2 mg/(kg⋅d)). Levels of TGF-β1, MMP-2, MMP-9, and TIMP-1 were determined by ELISA. Data are mean ± SEM . , , compared with the normal control group. , , compared with the COPD model group. , , compared with BUD group. CS = cigarette smoke; SB = Scutellaria baicalensis; BUD = Budesonide; MMP = matrix metalloproteinase; and TIMP = tissue inhibitor of metalloproteinase.

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