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Evidence-Based Complementary and Alternative Medicine
Volume 2018, Article ID 1491732, 6 pages
https://doi.org/10.1155/2018/1491732
Research Article

The Antibacterial Activity of Mass Galla Chinesis et Camelliae Fermentata on Helicobacter pylori Infection

1Department of Integrated Traditional Chinese and Western Medicine, Peking University First Hospital, Beijing 100034, China
2Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China

Correspondence should be addressed to Xue-zhi Zhang; ten.362@ihzeux.gnahz

Received 24 September 2017; Revised 11 January 2018; Accepted 17 January 2018; Published 12 February 2018

Academic Editor: Youn C. Kim

Copyright © 2018 Jing Yu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mass Galla chinesis et camelliae Fermentata (Chinese gall leaven, CGL) was investigated for activities against Helicobacter pylori (H. pylori) both in vitro and in vivo. The agar dilution method and time-kill curves, as in vitro assays and an in vivo study using a Kunming mice model, were performed. CGL demonstrated a strong anti-Helicobacter pylori activity in vitro with the minimal inhibitory concentrations (MICs) against multiple H. pylori strains of 0.5~8 mg/ml and the decreasing trend time-kill curves when increasing CGL concentrations. H. pylori eradication rates in vivo were evaluated based on rapid urease test (RUT) and histopathologic criteria. Results revealed that the eradication rates in the CGL groups were 40% (4/10) in the high dosage group, 33% (4/11) in the medium dosage group, and 18% (2/11) in the low dosage group, with the difference between the high dosage and H. pylori control groups being significant . The H. pylori colonization scores could be reduced partly by CGL. These in vivo results demonstrated that CGL in a rationally high dosage might be the most effective.