The Bioavailability and Pharmacokinetics of Silymarin SMEDDS Formulation Study in Healthy Thai Volunteers

Table 2

Pharmacokinetic parameters for the volunteers after taking a single oral dose of silymarin SMEDDS soft capsules (n=12).

Pharmacokinetic parameters (unit)	Arithmetic mean ± SD	Range
(ng/ml)	812.43 ± 434.07	259.47–1505.49
(ng.h/ml)	658.80 ± 266.23	268.29–1045.01
(ng.h/ml)	676.98 ± 268.34	274.10–1050.96
(h)	0.80 ± 0.44	0.25–1.67
()	0.5386 ± 0.2634	0.0924–0.9508
(h)	1.91 ± 1.85	0.73–7.50
CL (L.h)	104.50 ± 47.51	57.09–218.90
Vd (L)	263.95 ± 229.63	75.86–909.46

: maximum observed plasma concentration; : area under the plasma concentration versus time curve up to the last; : area under the plasma concentration versus time curve with the concentration extrapolated based on the elimination rate constant; : time to ; : elimination rate constant; : elimination half-life; CL: clearance; Vd: volume of distribution.