The Effect of a Hydrolyzed Polysaccharide Dietary Supplement on Biomarkers in Adults with Nonalcoholic Fatty Liver Disease
Table 4
Cytokines and growth factors at baseline and 45 and 90 days.
Measure
Reference range
Time
RBAC
Placebo
IL-6 (pg/mL)
0.6–2.8
Baseline
1.4 ± 1.4 (0.01, 4.8)
0.7 ± 0.9 (0.01, 2.1)
45 days
1.4 ± 0.9 (0.01, 2.7)
2.8 ± 1.7 (0.01, 5.2)
90 days
1.7 ± 0.9 (0.09, 3.3)
1.7 ± 1.3 (0.01, 4.2)
IL-18 (pg/mL)+
36.1–257.8
Baseline
446.1 ± 876 (64.5, 3,221)
256.4 ± 106.8 (86.6, 430.2)
45 days
196.3 ± 64.7 (49.6, 284)
371 ± 176.5 (83.8, 597.1)
90 days
221.3 ± 44.9 (153.5, 300.2)
263.3 ± 116.2 (75.7, 409.5)
IFN-γ (pg/mL)
0–3.0
Baseline
1.3 ± 1.5 (0.01, 5.1)
2.3 ± 2.5 (0.01, 7.8)
45 days
2.5 ± 1.9 (0.01, 7.4)
2.4 ± 0.9 (1.1, 4.2)
90 days
2.3 ± 1.5 (0.01, 4.9)
1.9 ± 1.8 (0.01, 4.9)
IL-2 (pg/mL
1.6–8.3
Baseline
8.4 ± 3.3 (4.2, 13.2)
7.8 ± 6.5 (0.01, 21.2)
45 days
7.5 ± 3.5 (0.01, 11.7)
7.6 ± 3.1 (4.9, 14.1)
90 days
6.5 ± 4 (3.8, 18.2)
8.2 ± 3.8 (4.5, 16.4)
TNF RII (pg/mL)
714.4–1,145.5
Baseline
136.2 ± 443.2 (369.7, 1,940)
1259.9 ± 709.5 (391.9, 2,749.3)
45 days
991.1 ± 277.5 (624.1, 1,530.6)
3449.2 ± 7,339.7 (596.1, 22,998.6)
90 days
1029.8 ± 275.5 (649.1, 1,564.1)
950.3 ± 506.4 (329.9, 1,753.1)
IL-17 (pg/mL)
1.4–5.0
Baseline
7.6 ± 8.2 (3.3, 33.4)
6.3 ± 3.7 (3.6, 16.9)
45 days
7.4 ± 6.2 (3.5, 25.8)
7.8 ± 4.7 (2.2, 16.7)
90 days
5.5 ± 3.7 (0.1, 10.9)
4.9 ± 3.3 (1.1, 10.2)
Note. Values are mean ± standard deviation (minimum, maximum). IL: interleukin; IFN: interferon; and TNF: tumor necrosis factor. Percent change difference from baseline to 90 days; +percent change difference from 45 days to 90 days.
