Bogijetong Decoction and Its Selected Formulation Are Involved in Alleviating Neuropathic Pain in a Rat Model of Chronic Constrictive Injury
Changes in pain susceptibility in CCI animals by BGJTD and BeD administration. (a) Comparison of pain scores in CCI rats sutured with silk and nylon threads. In each thread, 5-0 and 7-0 sizes were examined. (b-e) Effects of CCI and drug (BGJTD, BeD) administration on pain scores in mice. One week after nerve ligation, animals showing pain scores higher than 15 in terms of paw withdrawal frequency in von Frey test were selected and randomly assigned into different animal groups and administered BGJTD, BeD, and saline (SAL) for 1 week (b), 2 weeks (c), 3 weeks (d), and 4 weeks (e). Number of animals in each group in (a) through (e) = 5. Error bar (mean ± SEM). p < 0.01 and p < 0.001 vs. sham controls. ++p<0.01 vs. CCI with corresponding silk threads in (a). +++p<0.001 vs. CCI+SAL group in (d, e).