Bogijetong Decoction and Its Selected Formulation Are Involved in Alleviating Neuropathic Pain in a Rat Model of Chronic Constrictive Injury

Figure 7

Schematics of proposed mechanisms underlying BGJTD- or BeD-modulated pain responses. According to our data, signaling of TNF-α and TrkB appeared to increase after nerve ligation (a). TNF-α, which were decreased by BGJTD treatment, may cause weakening in retrograde signaling of TNFR into the cell body, leading to alleviating pain response (b). After BeD treatment, p-Erk1/2 and IL-6 signals, induced from Schwann cells and macrophages, may transmit the signals of IL-6R into the neuronal cell body (soma), inducing JAK/STAT activation and regulation of target gene expression including the repression of TrkB gene expression (c). Consequently, retrograde TrkB signaling would be attenuated and lead to alleviate pain response.

(a)

(b)

(c)