Metabolic Profiling Analysis of the Alleviation Effect of the Fractions of Niuhuang Jiedu Tablet on Realgar Induced Toxicity in Rats

Table 1

Clinical chemistry parameters.

Biochemical parameters	Control group	Realgar group	NJT group	NJT-PET group	NJT-25 group	NJT-50 group	NJT-75 group	NJT-95 group
AST (U/L)	106.24 ± 15.68	153.50 ± 29.27	118.00 ± 16.53	127.80 ± 20.92	138.80 ± 32.55	125.37 ± 12.26	120.39 ± 16.28	132.34 ± 25.58
ALT (U/L)	17.66 ± 3.01	39.67 ± 7.89	20.54 ± 5.21	26.11 ± 7.14	32.47 ± 4.56	19.21 ± 2.12	22.69 ± 6.08	33.76 ± 8.13
ALP (U/L)	111.29 ± 21.05	168.01 ± 37.14	123.17 ± 29.70	145.56 ± 18.93	118.85 ± 17.22	137.41 ± 15.12	105.96 ± 13.80	121.61 ± 20.45
BUN (mmol/L)	7.40 ± 0.68	12.33 ± 0.80	8.12 ± 1.25	8.44 ± 0.86	7.79 ± 0.53	8.64 ± 1.41	8.00 ± 0.75	10.81 ± 1.88
CREA (μmol/L)	15.76 ± 1.96	31.13 ± 4.02	16.11 ± 2.05	25.07 ± 5.62	19.00 ± 3.82	18.54 ± 3.49	16.08 ± 2.55	15.01 ± 0.97
TG (mmol/L)	0.49 ± 0.06	0.53 ± 0.05	0.55 ± 0.11	0.50 ± 0.04	0.60 ± 0.28	0.46 ± 0.17	0.57 ± 0.10	0.49 ± 0.05
TC (mmol/L)	1.22 ± 0.16	1.11 ± 0.28	1.51 ± 0.36	1.23 ± 0.23	1.44 ± 0.54	1.30 ± 0.19	1.30 ± 0.31	1.16 ± 0.27

Statistics. versus control group. Data are presented as mean ± SD of six animals per group.