Antitumor Research of the Active Ingredients from Traditional Chinese Medical Plant Polygonum Cuspidatum

Figure 7

Cell selectivity of polydatin. Polydatin induces apoptosis effectively with an increase in Bax expression and a decrease in Bcl-2 expression in lung cancer cells. Polydatin has a significant time- and dose-dependent inhibitory effect on the proliferation inhibition and apoptosis induction of HCC cells. Polydatin can induce apoptosis of human osteosarcoma cells by upregulation of the ratio of Bax/Bcl-2. Polydatin can induce the production of ROS which triggers ER stress and mitochondrial apoptotic pathways in CNE cells. It has a strong cytotoxicity to the growing Caco-2 cells. Polydatin can inhibit the activation of Creb, and the aim of inhibiting the proliferation of breast cancer cells.