Aqueous Extract of Semen<i> Ziziphi Spinosae</i> Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling

<div>(a) HPLC profile of AESZS, which contains magnoflorine, spinosin, and 6′′′-feruloylspinosin. (b) HPLC profile of AESZS, which contains jujuboside A. (c) Time schedule for NicW, rats were injected with Nic (0.4 mg/kg s.c., twice a day) for 7 consecutive days followed by 4 days of withdrawal and then analyzed for behavioral and neurochemical changes. During NicW, the rats were treated with AESZS (60 or 180mg/kg/d, four times). AESZS: aqueous extract of Semen<i> Ziziphi Spinosae</i>; Nic: nicotine; NicW: nicotine withdrawal.</div>

Evidence-Based Complementary and Alternative Medicine

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Figure 1: Aqueous Extract of Semen<i> Ziziphi Spinosae</i> Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling 

Figure 1 | Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling 