Aqueous Extract of Semen<i> Ziziphi Spinosae</i> Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling

<div>Effects of AESZS on innate anxiety in rats. All data are expressed as a mean ± SEM (<i>n</i> = 6). (a) The total number of entries into open and closed arms of the EPM by rats. (b) Percentage of numbers of entries into open arms of EPM by rats. (c) Percentage of time spent in open arms by rats. S: saline, DW: distilled water, AESZS: aqueous extract of Semen<i> Ziziphi Spinosae</i>, AESZS60: 60 mg/kg/d AESZS, AESZS180: 180 mg/kg/d AESZS. <sup># </sup><i>p</i> &lt; 0.05, versus naive group; <svg height="12.2304pt" id="M8" style="vertical-align:-0.04990005pt" version="1.1" viewbox="-0.0498162 -12.1805 4.98213 12.2304" width="4.98213pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M263 363V584C343 572 363 521 380 464L408 470C399 526 392 562 387 596C376 598 367 601 353 604C328 612 296 617 263 617V693H228V615C122 603 67 532 67 453C67 376 123 329 193 300L228 284V41C132 52 93 131 75 189L45 181C54 130 66 71 73 50C113 24 170 9 228 9V-76H263V11C370 24 434 90 434 185C434 275 367 325 292 352L263 363ZM228 376C171 398 136 431 136 484C136 530 164 578 228 584V376ZM263 272L275 267C345 236 359 196 359 150C359 96 325 50 263 42V272Z"></path></g></svg><i> p </i>&lt; 0.05, versus DW group (one-way ANOVA followed by Newman-Keuls post hoc test).</div>

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Figure 2

Figure 2: Aqueous Extract of Semen<i> Ziziphi Spinosae</i> Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling 

Figure 2 | Aqueous Extract of Semen Ziziphi Spinosae Exerts Anxiolytic Effects during Nicotine Withdrawal via Improvement of Amygdaloid CRF/CRF1R Signaling 