Evidence-Based Complementary and Alternative Medicine

Review Article

A Meta-Analysis of the Clinical Efficacy of TCM Decoctions Made from Formulas in the Liuwei Dihuang Wan Categorized Formulas in Treating Diabetic Nephropathy Proteinuria

Table 1

Characteristics and methodological quality of included studies.
Reference (year)Participants (T/C)stages of MogensenAverage age (years)Intervention (dosage)Control (dosage)Treatment duration (days)
Zhou (2009) [24]90 (48/42)Phase IIIT 55.3;
C 53.8		Jisheng Shenqi Wan pluse Captopril (25-75mg/d)Captopril (25-75mg/d)42
Zhang (2012) [25]46 (23/23)Phase II-IVT 36.5;
C 35.3		Jisheng Shenqi Wan pluse Benazepril Hydrochloride (10mg, qd)Benazepril Hydrochloride (10mg, qd)40
Yu (2008) [26]60 (30/30)Phase IIIT 53±17;
C 54±16		Liuwei Dihuang Wan pluse Valsartan (80mg/d)Valsartan (80mg/d)84
Xia (2008) [27]64 (32/32)Phase IVT 56.70±4.23;
C 55.34±3.33		Jingui Shenqi Wan pluse Valsartan (80mg/d)Valsartan (80mg/d)30
Xiong et al. (2003) [28]78 (40/38)Phase IVT 46.35±4.17;
C 43.58±4.16		Jisheng Shenqi Wan pluse Captopril (25-75mg/d)Captopril (25-75mg/d)42
Wu (2016) [29]37 (18/19)Phase III——Jingui Shenqi WanRoutine treatment30
Wen (2011) [30]40 (20/20)Phase IVT 52.5±11.5;
C 50.1±10.7		Liuwei Dihuang Wan pluse Astragalus membranaceus pluse Captopril (25mg/d)Captopril (25mg/d)28
Tan (2014) [31]43 (22/21)Phase IVT 59.72±3.17;
C 61.32±2.27		Liuwei Dihuang Wan pluse Benazepril Hydrochloride (10mg, qd)Benazepril Hydrochloride (10mg, qd)56
Liu et al. (2014) [32]158 (79/79)Phase IVT 57.5±20.1;
C 58.6±19.3		Liuwei Dihuang WanRoutine treatment60
Li (2004) [33]40 (20/20)Phase IIIT 51.3;
C 52.3		Liuwei Dihuang Wan pluse Enalapril (10mg/d)Enalapril (10mg/d)84
Lei (2011) [34]84 (43/41)Phase IIIT 55.44±5.98;
C 55.95±6.99		Liuwei Dihuang WanTelmisartan (80mg/d)84
Jin (2014) [35]50 (25/25)Phase IIIT 40±13.5;
C 38±12.3		Liuwei Dihuang Wan pluse Valsartan (80mg/d)Valsartan (80mg/d)90
Cui et al. (2011) [36]66 (33/33)Phase III52.3Liuwei Dihuang WanRoutine treatment56
Zhang (2004) [37]62 (31/31)Phase IIIT 59.8;
C 58.4		Zhibai Dihuang WanRoutine treatment90